Cord plasma concentrations of adiponectin and leptin in healthy term neonates: positive correlation with birthweight and neonatal adiposity

Tsai, Po Jung; Yu, Chun Hsien; Hsu, Shih Penn; Lee, Yu Hsiang; Chiou, Chuen Hua; Hsu, Yu Wen; Ho, Su Chen; Chu, Chun Hong

doi:10.1111/j.1365-2265.2004.02057.x

Cited by 170 publications

(170 citation statements)

References 30 publications

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“…(9) found no significant correlation between adiponectin concentration and anthropometric parameters. Another study suggested a reverse correlation between PI and adiponectin concentration (11,25). Some studies have shown a positive correlation between adiponectin concentration and birth weight (8,12,14,(16)(17)(18)(19)(20), but few have failed to find a significant correlation (9,15).…”

Section: Discussionmentioning

confidence: 99%

Relation between fetal anthropometric parameters and cord blood adiponectin and high-sensitivity C-reactive protein in gestational diabetes mellitus

Aramesh

Dehdashtian

Malekian

et al. 2017

Arch. Endocrinol. Metab.

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Objectives:The objectives were to evaluate the relation between fetal anthropometric parameters and cord blood concentration of adiponectin and high sensitivity C-reactive protein (hs-CRP). Subjects and methods: A total of 104 pregnant women (52 with gestational diabetes mellitus [GDM], 52 with normal glucose tolerance (NGT) participated. Venous cord blood samples were obtained at delivery, centrifuged and the plasma was stored at -20°C. The samples were assessed for adiponectin and hs-CRP using the ELISA method. Statistical analysis was done using SPSS software. Results: The adiponectin concentration was higher in the GDM group than in the NGT group (11.05 ± 4

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Section: Discussionmentioning

confidence: 99%

Relation between fetal anthropometric parameters and cord blood adiponectin and high-sensitivity C-reactive protein in gestational diabetes mellitus

Aramesh

Dehdashtian

Malekian

et al. 2017

Arch. Endocrinol. Metab.

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“…11 Recent studies have shown that cord blood adiponectin concentrations are correlated positively with birth weight, suggesting that fetal adiponectin levels are likely to influence fetal growth. 8,10,27,28 MazakiTovi et al 29 have reported that the cord blood adiponectin concentration in the smaller neonate of discordant twins is lower than that in the larger counterpart. Our result showing that cord blood adiponectin concentrations were positively correlated with birth weight s.d.…”

Section: Adiponectin Snps and Cord Blood Adiponectin M Saito Et Almentioning

confidence: 99%

“…Furthermore, we confirmed previous findings of no gender difference in adiponectin levels. 8,10,11,28 Serum adiponectin levels are known to be inversely correlated with body fat mass in adolescents and adults, whereas cord blood adiponectin concentrations are positively correlated with birth weight s.d. score, mostly determined by fat mass.…”

Section: Adiponectin Snps and Cord Blood Adiponectin M Saito Et Almentioning

confidence: 99%

“…6,7 Some investigators have reported a significant positive relationship between birth weight, as a proxy mirror of the intrauterine environment, and cord blood adiponectin levels. [8][9][10] Our previous study demonstrated that the serum adiponectin levels on the first day of life were significantly higher in appropriate-for-gestational-age birth weight (AGA) than in small-for-gestational-age birth weight (SGA) term neonates. 11 Although adiponectin levels in the cord blood of term infants are extensively higher than in children or adults, its exact physiological role in regulating intrauterine fetal growth has not been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

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Association of adiponectin polymorphism with cord blood adiponectin concentrations and intrauterine growth

et al. 2011

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To assess whether adiponectin gene (ADIPOQ) polymorphism is associated with intrauterine fetal growth and cord blood adiponectin, we investigated eight single-nucleotide polymorphisms (SNPs; rs182052, rs710445, rs16861205, rs12495941, rs1501299, rs3774261, rs2082940 and rs266729) in ADIPOQ and birth weight and cord blood adiponectin in 526 healthy neonates. We found that the neonates carrying the G allele of rs266729 had a significantly greater birth weight s.d. score than those homozygous for the C allele (CC: À0.06 ± 0.75 versus CG: 0.20 ± 0.64 versus GG: 0.07 ± 0.78; P¼1.65Â10 À3 , adjusted P¼9.90Â10 À3 ). However, this difference was not significant after adjustment for cord blood adiponectin (P¼0.04, adjusted P¼0.26). The rs266729 SNP was strongly associated with cord blood adiponectin; neonates with rs266729 GG had the highest adiponectin (CC: 34.1 ± 20.2 versus CG: 44.3 ± 26.1 versus GG: 54.1 ± 36.7 lg ml -1 , P¼2.80Â10 À9 , adjusted P¼1.68Â10 À8 ). This association remained after adjustment for birth weight s.d. score (P¼6.63Â10 À8 , adjusted P¼3.98Â10 À7 ). Our results suggest that the influence of the rs266729 SNP in ADIPOQ on birth weight may be dependent on circulating adiponectin.

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“…Circulating leptin levels correlate with fat mass in adults and children [11]. Leptin is detectable in cord blood from the second trimester of intrauterine life and correlates with adiposity at birth [12]. Interestingly, serum leptin concentration correlates with body mass index (BMI) in infants [13].…”

Section: Introductionmentioning

confidence: 99%

Breast Milk Hormones and Their Protective Effect on Obesity

Savino

Liguori

Fissore

et al. 2009

International Journal of Pediatric Endocrinology

101

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Data accumulated over recent years have significantly advanced our understanding of growth factors, cytokines, and hormones in breast milk. Here we deal with leptin, adiponectin, IGF-I, ghrelin, and the more recently discovered hormones, obestatin, and resistin, which are present in breast milk and involved in food intake regulation and energy balance. Little is known about these compounds in infant milk formulas. Nutrition in infancy has been implicated in the long-term tendency to obesity, and a longer duration of breastfeeding appears to protect against its development. Diet-related differences in serum leptin and ghrelin values in infancy might explain anthropometric differences and differences in dietary habits between breast-fed and formula-fed infants also later in life. However, there are still gaps in our understanding of how hormones present in breast milk affect children. Here we examine the data related to hormones contained in mother's milk and their potential protective effect on subsequent obesity.

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Cord plasma concentrations of adiponectin and leptin in healthy term neonates: positive correlation with birthweight and neonatal adiposity

Abstract: High adiponectin levels are present in the cord blood. Cord plasma adiponectin and leptin levels are positively correlated with birthweight and adiposity. This suggests that adiponectin may be involved in regulating fetal growth.

Cited by 170 publications

References 30 publications

Relation between fetal anthropometric parameters and cord blood adiponectin and high-sensitivity C-reactive protein in gestational diabetes mellitus

Relation between fetal anthropometric parameters and cord blood adiponectin and high-sensitivity C-reactive protein in gestational diabetes mellitus

Association of adiponectin polymorphism with cord blood adiponectin concentrations and intrauterine growth

Breast Milk Hormones and Their Protective Effect on Obesity

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