Cord Plasma Vasopressin, Erythropoietin, and Hypoxanthine as Indices of Asphyxia at Birth

Ruth, Vineta; Fyhrquist, F; Clemons, Gisela K.; Raivio, Kari O.

doi:10.1203/00006450-198810000-00015

Cited by 76 publications

(33 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…11 Similar to the study done by Ramesh R Pol et al, there is significant difference found in the values of hemoglobin between cases and controls. 5 But unlike their study, significant difference was not found in value of hematocrit when compared between cases and controls. Similar to finding in their study, leucocyte count was higher among the cases with highest among the HIE-III cases which may be due to the oxidative stress present during birth.…”

Section: Discussioncontrasting

confidence: 48%

“…Many acute and chronic stimuli cause increase in the number of circulating n-RBCs from either increased erythropoetic activity or a sudden release from the marrow storage pools. 5 The number of n-RBC /100 WBCs is variable but is rarely more than 10 6-8 . Frequent conditions like prematurity, rhesus sensitization, in which the number of n-RBCs exceeds 10, have been excluded from our study.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Simple and feasible blood markers-as predictors of perinatal asphyxia

Koreti

Gupta

2017

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: The objective of this research work was to study the hematological parameters as predictors of perinatal asphyxia and to assess their correlation with severity. Setting: Postnatal Wards, Kamla Raja Hospital and SNCU, Department of Pediatrics, Kamla Raja Hospital, Gajra Raja Medical College, Gwalior. Design: A prospective case control study. Participants :100 cases and 100 controls enrolled based on the selection criteria, on day 1 of life.Methods: New born on day 1, who fits the selection criteria was enrolled. Birth details, relevant perinatal history, findings on physical examination and systemic signs were recorded on a predesigned proforma. Staging was done and new born classified as HIE stage I, II or III. Cord blood samples were collected and results analysed. Results: This study included 100 cases and 100 controls. Presence of maternal illness and birth history were found to have significance (p value <0.001) when compared between cases and controls. Number of nucleated RBCs/100 WBCs were found to be 6±1.93 in HIE-I; 9.5±4.8 in HIE-II and 16.45±6.6 in HIE-III as compared to 5.9±3.6 among the controls. The results are found to be significant (p value <0.001). Mean value of hemoglobin found among the controls was 16±2.5. This was 17.4±2.18 in HIE-I; 17.45±1.8 in HIE-II and 15.5±3.07 in HIE-III. The results are significant on comparison between cases and controls and among cases (p value <0.015, <0.001 respectively). Mean value of hematocrit among the controls was 49.24±7.98. This was 52.5±6.57 in HIE-I;52.56±5.46 in HIE-II and 47.6±5.8 in HIE-III. The difference was significant (p value <0.001) when comparison was done among the cases. Value of total leucocyte count (TLC) among the controls was 14.14±4.15; 14.06±6.8 in HIE-I;15.8±5.6 in HIE-II; 21.14±7.90 in HIE-III. The results were significant (p value <0.001) when comparing cases with controls and cases among themselves. There was no correlation seen with platelet count. Polychromatophilia was found significant (p value <0.001) when compared between cases and controls and among cases themselves.Conclusions:Hematological parameters are altered in perinatal asphyxia and can be used to predict the severity and outcome.

show abstract

Section: Discussioncontrasting

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Simple and feasible blood markers-as predictors of perinatal asphyxia

Koreti

Gupta

2017

Int J Contemp Pediatr

View full text Add to dashboard Cite

show abstract

“…[35] Traditionally it has been thought that EPO, in response to hypoxia, is the main driving force behind NRBC production. [36,37] It has also been thought that the duration and severity of fetal hypoxia may be predicted by the number of increased NRBCs in the neonates delivered both preterm and at term. [12,33,38] Recent data has questioned whether hypoxia is the sole mechanism responsible for an increase in the fetal NRBC.…”

Section: Discussionmentioning

confidence: 99%

Nucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsis

Dulay

Buhimschi

Zhao

et al. 2008

American Journal of Obstetrics and Gynecology

View full text Add to dashboard Cite

Objective-To test the hypothesis that inflammation modulates fetal erythroblastosis and/or the release of NRBCs independent of hypoxia or fetal stress. We sought to determine if fetal inflammation is associated with an elevation in neonatal NRBC count in the setting of inflammation-associated preterm birth.Study Design-The relationships between peripheral NRBC count, histological chorioamnionitis, umbilical cord interleukin-6 (IL-6), erythropoietin (EPO), cortisol and acid-base status were analyzed in 68 preterm singletons, born to mothers who had an amniocentesis to rule out infection. Proteomic profiling of amniotic fluid identified presence of intra-amniotic inflammation according to established parameters. NRBC counts were assessed within 1-hour of birth. Early-onset neonatal sepsis (EONS) was established based on hematological and microbiological indices. IL-6, EPO and cortisol levels were measured by immunoassays. Fetal acid-base status was determined within 10 minutes of delivery. Parametric or nonparametric statistics was employed.Results-Fetuses with EONS (n=19) were delivered at earlier gestational ages (mean±SD: 27.1±2.8 weeks, P=0.001) and more often by mothers with intra-amniotic inflammation (P=0.022) and histological chorioamnionitis (P<0.001). Neonates with EONS had higher absolute NRBCs Condensation:In inflammation-associated preterm birth and in the absence of hypoxia, elevated neonatal nucleated red blood cell counts may be a direct response to inflammatory mediators. Authors' Contributions:Antonette Dulay is the principal investigator and responsible author. Antonette Dulay, Irina Buhimschi and Catalin Buhimschi designed the study, generated, interpreted the data and wrote the initial draft of the manuscript. Guomao Zhao participated with processing of biological samples, performed immunoassays, revised critically the manuscript and approved the final version. Vineet Bhandari participated with aspects of data analysis and interpretation, revised critically the manuscript and approved the final version. Guoyang Luo; Sonya Abdel-Razeq; Michael Cackovic, Victor Rosenberg, Christian Pettker Stephen Thung and Mert Ozan Bahtiyar participated with patient enrollment, acquisition of demographic and clinical data, critical revision of the manuscript and approved the final version. NIH Public AccessAuthor Manuscript Am J Obstet Gynecol. Author manuscript; available in PMC 2014 May 16. Published in final edited form as: Am J Obstet Gynecol. 2008 April ; 198(4): 426.e1-426.e9. doi:10.1016/j.ajog.2008 NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author Manuscript counts (P=0.011). NRBC counts were directly correlated with cord blood IL-6 levels (P<0.001) but not with EPO, cortisol or parameters of acid-base status levels regardless of EONS status. These relationships remained following correction for gestational age, diabetes, intrauterine growth restriction (IUGR) and steroid exposure.Conclusion-In the setting of inflammation-associated preterm birth and in the absence of hypoxia,...

show abstract

“…A asfixia também desencadeia um rápido aumento na secreção de vários hormônios, entre eles catecolaminas 2 , glicocorticóides [2][3][4] , ACTH 4 , ß-endorfinas 4 , hormônio antidiurético [5][6][7][8] , aldosterona 1,2,9,10 , renina 11 e peptídeo atrial natriurético 9,12 , bem como uma diminuição na insulina 1 .…”

unclassified

Effect of Perinatal Asphyxia on Thyroid Hormones

Pereira¹,

Procianoy²

2001

J Pediatr (Rio J)

View full text Add to dashboard Cite

ResumoObjetivo: verificar o efeito da asfixia perinatal sobre os hormô-nios tireóideos.Métodos: foi realizado um estudo de caso-controle, no hospital de Clínicas de Porto Alegre, envolvendo 17 recém-nascidos a termo asfixiados (A) e 17 não-asfixiados (N), pareados conforme a cor, sexo, tipo de parto, idade gestacional e peso de nascimento. Foram coletados T4, T3, T4 livre, T3 reverso e TSH do sangue do cordão e do recém-nascido com 18 a 24 horas de vida, entre os que sofreram ou não asfixia perinatal.Resultados: no sangue de cordão, não houve diferença na dosagem dos hormônios tireóideos, com exceção do T3 reverso, que foi mais elevado no grupo que sofreu asfixia [mediana (percentis 25-75):A= 2(1,4-2); N= 1,41(1,13-1,92); p=0,037]. Com 18 a 24 horas de vida, foram significativamente menores no grupo de asfixiados, com exceção do T3 reverso, que foi semelhante entre os dois grupos [média ± DP: T4 A= 9,79 ± 2,59; N=14,68 ± 3,05; p<0,001/ mediana T3 A= 40,83(37,4-80,4); N= 164(56,96-222,5); P=0,003/ média ± DP T4 livre A=1,85 ± 0,92; N= 2,8 ± 0,74; p=0,004/ mediana T3 reverso A= 1,54(1,16-1,91); N= 1,31(0,87-2); p=0,507/ TSH A= 9,1(6,34-12,95); N=14,5(12,9-17,85); p=0,008].Conclusões: nossos dados sugerem que os níveis diminuídos de T4, T4 livre e T3 no recém-nascido asfixiado com 18 a 24 horas de vida são secundários aos níveis diminuídos de TSH. Além disso, os valores baixos de T3 e normais de T3 reverso podem refletir alteração no metabolismo periférico do T4.J Pediatr (Rio J) 2001; 77 (3): 175-78: hormônios da tireóide, asfixia perinatal, síndrome do doente eutireóideo. AbstractObjective: to verify the effect of perinatal asphyxia on thyroid hormone levels in term newborn infants.Methods: we carried out a case-control study with 17 term and asphyxiated (A) and 17 term and control (N) newborn infants at the Hospital de Clínicas de Porto Alegre. Patients were paired according to color of skin, sex, mode of delivery, gestational age, and weight at birth. We collected plasmatic T4, T3, free T4, reverse T3, and TSH of the umbilical cord after 18 to 24 hours of life and from asphyxiated and control newborn infants.Results: there were no differences in thyroid hormones of cord blood, with the exception of reverse T3, which was higher in A than in controls [median (percentile 25-75): A= 2(1.4-2); N= 1.41 (1.13-1.92); P=0.037)]. Thyroid hormone levels were lower in A than in controls on 18-24-hour after birth samples, except for reverse T3, which was similar in both groups [average ± SD: T4 A= 9.79 ± 2.59; N=14.68 ± 3.05; P<0.001; median T3 A= 40.83 (37.4-80.4); N= 164 (56.96-222.5); P=0.003; average ± SD: free T4 A=1.85 ± 0.92; N= 2.8 ± 0.74; P=0.004; median: reverse T3 A=1.54 (1.16-1.91); N=1.31(0.87-2); P=0.507; TSH A=9.1 (6.34-12.95); N=14.5(12.9-17.85); P=0.008].Conclusions: our data suggests that lower T4, free T4, and T3 levels are secondary to lower TSH levels in asphyxiated newborns; also, peripheral metabolism of T4 in asphyxiated infants can be altered due to low T3 and normal reverse T3 levels.J Pediatr (Rio...

show abstract

Cord Plasma Vasopressin, Erythropoietin, and Hypoxanthine as Indices of Asphyxia at Birth

Cited by 76 publications

References 24 publications

Simple and feasible blood markers-as predictors of perinatal asphyxia

Simple and feasible blood markers-as predictors of perinatal asphyxia

Nucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsis

Effect of Perinatal Asphyxia on Thyroid Hormones

Contact Info

Product

Resources

About