Cord Serum Cytokines at Birth and Children’s Anxiety-Depression Trajectories From 3 to 8 Years: The EDEN Mother–Child Cohort

Galèra, Cédric; Barbosa, Susana; Collet, Ophélie; Khalfallah, Olfa; Aouizerate, Bruno; Sutter-Dalley, Anne-Laure; Koehl, Muriel; Capuron, Lucile; Waerden, Judith van der; Melchior, Maria; Côté, Sylvana; Heude, Barbara; Glaichenhaus, Nicolas; Davidovic, Laetitia

doi:10.1016/j.biopsych.2020.10.009

Cited by 6 publications

(3 citation statements)

References 43 publications

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“…Maternal infection during pregnancy is associated with increased depressive- and anxiety-like behaviours in male offspring ( Enayati et al., 2012 ), and in response to late-gestation immune activation, changes can be observed in neuroimmune gene expression immediately postpartum, in females ( Posillico and Schwarz, 2016 ). This idea has also been recently supported by human cohort studies, including a study in a French birth cohort, which showed that higher levels of IL-7 in the cord serum at birth were associated with a lower likelihood of child anxiety and depression symptoms between age 3 and 8 years ( Galera et al., 2021 ).…”

Section: Offspring Outcomesmentioning

confidence: 71%

The role of inflammation in the pathogenesis of perinatal depression and offspring outcomes

Sawyer

2021

Brain, Behavior, & Immunity - Health

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The role of inflammation in the pathogenesis of depression is becoming increasingly apparent, but its role in perinatal depression is less well-studied. Pregnancy and the postpartum are characterised by distinct and changing inflammatory profiles throughout, which makes the study of depression-related alterations in this period complex. This review presents literature discussing a role for the immune system in both antenatal and postnatal depression. Furthermore, literature investigating the role of the maternal immune system on breast milk composition and offspring immunological and behavioural outcomes is discussed, before concluding with suggestions for future work as this developing field grows.

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Section: Offspring Outcomesmentioning

confidence: 71%

The role of inflammation in the pathogenesis of perinatal depression and offspring outcomes

Sawyer

2021

Brain, Behavior, & Immunity - Health

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“…An increase of the important proinflammatory IL-7, IL-7 in umbilical cord samples showed correlations with an increased risk of retinopathy of prematurity and with internalizing neurological disorders (increased incidence of anxiety-depression, depression) in adults [58][59][60].…”

Section: Discussionmentioning

confidence: 96%

Pro-Inflammatory Biomarkers and Long Term Neurological Outcomes in Hypothermia Plus Melatonin Treated Newborns. A Pilot Clinical Trial

Jerez-Calero,

Contreras-Chova,

Benitez-Feliponi

et al. 2024

Preprint

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Objective. To evaluate serum neuronal and inflammatory biomarkers in asphyctic newborns treated with hypothermia alone or hypothermia plus melatonin, and whether biomarkers correlate with neurodevelopmental outcomes. Design. This is a pilot multicentre, randomised, controlled, double blind clinical trial. Neuronal glial fibrillary acidic protein (GFAP), granulocyte-macrophage colony-stimulating factor (GM-CSF), and inflammatory cytokines (interleukin (IL)-1, IL-2, IL-7 and IL-13) were measured in serum samples at hospital admission (T0), 24 hours (T1), 72 hours (T2) and 7-10 days of age (T3). Neurodevelopmental outcomes (Bayley Scales of Infant and Toddler Development-III scales, Gross Motor Function Classification System (GMFCS) and the Tardieu scale) were performed at 6 and 18 months. Setting: Level 3 neonatal intensive care unit. Patients and interventions: 25 newborns were recruited. The treated patients received a daily dose of intravenous melatonin, 5 mg per kg body weight, for 3 days. Results. After adjusting the data for severity, in the group treated with melatonin, there is a decrease in plasma levels of GM-CSF, IL-2 and IL-13 at T1 compared to placebo, as well as, at T2, in GM-CSF concentrations, as well as IL-7 and IL-13 at T3. Evolutionarily, we found a significant decrease in GM-CSF concentrations in the treatment group compared to placebo, with no differences for the rest of the biomarkers. It is noteworthy that the sustained decrease in GM-CSF and inflammatory cytokines IL-2, IL-7 and IL-13 correlated with better neurodevelopmental outcomes at 6 and 18 months. Conclusions. In neonates with hypoxic-ischemic encephalopathy, the addition of iv melatonin to hypothermia therapy affects the plasma concentration of biomarkers in the first week of life, with a high correlation with long-term neurological prognosis.

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“…In humans, the few epidemiological studies available have confirmed that MIA is linked to ASD onset. Interestingly, schizophrenia has been found to be associated with elevated maternal IL-8 blood concentrations during the second trimester of pregnancy, and anxiety-depression symptoms were related with lower IL-7 in the cord serum at birth ( Al-Haddad et al, 2019 ; Ratnayake et al, 2013 ; Galera et al, 2021 ). Furthermore, prenatal exposure, during the third trimester to maternal imbalance of immune activity resulted in dysregulation of the stress circuitry at 45, with sex-dependent effects ( Goldstein et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Cord serum cytokines at birth and children's trajectories of mood dysregulation symptoms from 3 to 8 years: The EDEN birth cohort

Herbein,

Barbosa,

Collet

et al. 2024

Brain, Behavior, & Immunity - Health

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Cord Serum Cytokines at Birth and Children’s Anxiety-Depression Trajectories From 3 to 8 Years: The EDEN Mother–Child Cohort

Cited by 6 publications

References 43 publications

The role of inflammation in the pathogenesis of perinatal depression and offspring outcomes

The role of inflammation in the pathogenesis of perinatal depression and offspring outcomes

Pro-Inflammatory Biomarkers and Long Term Neurological Outcomes in Hypothermia Plus Melatonin Treated Newborns. A Pilot Clinical Trial

Cord serum cytokines at birth and children's trajectories of mood dysregulation symptoms from 3 to 8 years: The EDEN birth cohort

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