Cordycepin alleviates lipopolysaccharide-induced acute lung injury via Nrf2/HO-1 pathway

Qing, Rui; Huang, Zezhi; Tang, Yufei; Xiang, Qingke; Yang, Fan

doi:10.1016/j.intimp.2018.04.032

Cited by 28 publications

(29 citation statements)

References 30 publications

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“…nF-κB signaling is essential for the regulation of the inflammatory response in sepsis-induced ali (35), and activation of the nrf2/Ho-1 signaling pathway may relieve sepsis-induced ALI by suppressing inflammation and oxidative stress (36,37). increasing evidence has demonstrated that regulation of the nrf2/Ho-1 and nF-κB signaling pathways alleviates lung injury induced by ventilator, by suppressing inflammation and oxidative stress (38).…”

Section: Discussionmentioning

confidence: 99%

Sufentanil attenuates inflammation and oxidative stress in sepsis-induced acute lung injury by downregulating KNG1 expression

Wang

Han

et al. 2020

Mol Med Rep

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The present study aimed to investigate the effects of sufentanil on sepsis-induced acute lung injury (ali), and identify the potential molecular mechanisms underlying its effect. in order to achieve this, a rat sepsis model was established. Following treatment with sufentanil, the lung wet/dry (W/d) weight ratio was calculated. Histopathological analysis was performed via hematoxylin and eosin staining. Levels of inflammatory factors in bronchoalveolar lavage fluid were determined via eliSa. Furthermore, malondialdehyde (Mda) content and the activities of superoxide dismutase (Sod), catalase (caT) and glutathione peroxidase (GSH-Px) in tissue homogenates were assessed using commercial kits. Western blot analysis was performed to determine kininogen-1 (KnG1) protein expression. in addition, alveolar epithelial type ii cells (aec ii) were stimulated with lipopolysaccharide (LPS) to mimic ALI. The levels of inflammation and oxidative stress were evaluated following overexpression of KnG1. Protein expression levels of nuclear factor-κB (nF-κB) and nuclear factor erythroid 2-related factor 2 (nrf2)/heme oxygenase-1 (Ho-1) signaling were determined via western blot analysis. The results of the present study demonstrated that sufentanil alleviated histopathological injury and the W/d ratio in lung tissue. Following treatment with sufentanil, levels of inflammatory factors also decreased, accompanied by decreased concentrations of Mda, and increased activities of Sod, caT and GSH-Px. notably, KnG1 was decreased in lung tissues following treatment with sufentanil. Furthermore, overexpression of KnG1 attenuated the inhibitory effects of sufentanil on lPS-induced inflammation and oxidative stress in aec ii. Sufentanil markedly downregulated nF-κB expression, while upregulating nrf2 and Ho-1 expression levels, which was reversed following overexpression of KnG1. Taken together, the results of the present study suggested that sufentanil may alleviate inflammation and oxidative stress in sepsis-induced ali by downregulating KnG1 expression.

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Section: Discussionmentioning

confidence: 99%

Sufentanil attenuates inflammation and oxidative stress in sepsis-induced acute lung injury by downregulating KNG1 expression

Wang

Han

et al. 2020

Mol Med Rep

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“…Link., was found to decrease the lung edema, MPO activity, MDA content, and inflammatory cytokines production (TNF-α, IL-1β, IL-6, iNOS and NO) in ALI mice induced by LPS. In terms of the underlying mechanism, cordycepin dramatically up-regulated the Nrf2 signaling pathway and down-regulated the NF-κB signaling pathways [ 203 , 204 ].…”

Section: Natural Compounds That Exert Anti-ali Effectsmentioning

confidence: 99%

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Zhou

et al. 2021

Pharmacological Research

251

121

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“…The pro‐inflammatory cytokines TNF‐α, IL–1β, IL‐6, IL‐8, and IL‐18 are among the most promising biomarkers for predicting morbidity and mortality (Butt, Kurdowska, & Allen, 2016). LPS‐induced ALI models resemble certain features of human ALI; cordycepin is found to markedly reduce neutrophil accumulation and MPO activity in lung tissues, decrease the production of inflammatory cytokines including TNF‐α, IL‐6, and IL‐1β, and attenuate lung inflammation in this model probably by the activation of Nrf2 and up‐regulation of HO‐1 expression (J. Lei et al, 2018; Qing et al, 2018). The inhibitory effect of cordycepin on TNF‐α and IL‐6 secretion is attenuated by prior administration of SnPP, a potent HO‐1 inhibitor, implicating that cordycepin confers protection against ALI via activation of HO‐1.…”

Section: Anti‐inflammatory Activitymentioning

confidence: 89%

“…cordycepin is found to markedly reduce neutrophil accumulation and MPO activity in lung tissues, decrease the production of inflammatory cytokines including TNF-α, IL-6, and IL-1β, and attenuate lung inflammation in this model probably by the activation of Nrf2 and upregulation of HO-1 expression (J. Lei et al, 2018;Qing et al, 2018).…”

Section: Lps-induced Ali Models Resemble Certain Features Of Human Ali;mentioning

confidence: 90%

“…The inhibitory effect of cordycepin on TNF‐α and IL‐6 secretion is attenuated by prior administration of SnPP, a potent HO‐1 inhibitor, implicating that cordycepin confers protection against ALI via activation of HO‐1. Notably, cordycepin treatment increases the concentration of IL‐10, which positively regulates inflammation (Qing et al, 2018). In a separate study, cordycepin has shown to significantly decrease LPS‐induced lung wet/dry (W/D) ratio and MDA levels.…”

Section: Anti‐inflammatory Activitymentioning

confidence: 99%

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Anti‐inflammatory effects of cordycepin: A review

Tan

Song

Ren

et al. 2020

Phytotherapy Research

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Cordycepin is the major bioactive component extracted from Cordyceps militaris. In recent years, cordycepin has received increasing attention owing to its multiple pharmacological activities. This study reviews recent researches on the anti-inflammatory effects and the related activities of cordycepin. The results from our review indicate that cordycepin exerts protective effects against inflammatory injury for many diseases including acute lung injury (ALI), asthma, rheumatoid arthritis, Parkinson's disease (PD), hepatitis, atherosclerosis, and atopic dermatitis. Cordycepin regulates the NF-κB, RIP2/Caspase-1, Akt/GSK-3β/p70S6K, TGF-β/Smads, and Nrf2/HO-1 signaling pathways among others. Several studies focusing on cordycepin derivatives were reviewed and found to down metabolic velocity of cordycepin and increase its bioavailability. Moreover, cordycepin enhanced immunity, inhibited the proliferation of viral RNA, and suppressed cytokine storms, thereby suggesting its potential to treat COVID-19 and other viral infections. From the collected and reviewed information, this article provides the theoretical basis for the clinical applications of cordycepin and discusses the path for future studies focusing on expanding the medicinal use of cordycepin. Taken together, cordycepin and its analogs show great potential as the next new class of anti-inflammatory agents.

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Cordycepin alleviates lipopolysaccharide-induced acute lung injury via Nrf2/HO-1 pathway

Cited by 28 publications

References 30 publications

Sufentanil attenuates inflammation and oxidative stress in sepsis-induced acute lung injury by downregulating KNG1 expression

Sufentanil attenuates inflammation and oxidative stress in sepsis-induced acute lung injury by downregulating KNG1 expression

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Anti‐inflammatory effects of cordycepin: A review

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