Cordyceps militaris acidic polysaccharides improve learning and memory impairment in mice with exercise fatigue through the PI3K/NRF2/HO-1 signalling pathway

Bai, Lidan; Tan, Chaojie; Ren, Jing; Liu, Jingyi; Liu, Guangchen; Yu, Shuang

doi:10.1016/j.ijbiomac.2022.12.071

Cited by 24 publications

(12 citation statements)

References 35 publications

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“…Nrf2 can regulate glucose uptake and metabolism of neurons ( Esteras et al, 2023 ), autophagy ( Li et al, 2021 ), ferroptosis ( Song et al, 2023 ), inflammation ( Wang J. et al, 2023 ), mitochondrial function ( Jamwal et al, 2021 ), and promote energy metabolism ( Esteras et al, 2023 ), which helps to maintain the health and survival of neurons. For example, CMPB can improve learning and memory impairment caused by fatigue by regulating PI3K/NRF2/HO-1 signal pathway, scavenging free radicals and fatigue metabolites, increasing the content of glycogen and regulating the content of central neurotransmitters in the body ( Bai et al, 2023 ). Pharmacological or genetic activation of Nrf2 has shown promising therapeutic potential in preclinical models of neurological disorders ( Li et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Insight into Nrf2: a bibliometric and visual analysis from 2000 to 2022

Ma,

Wang,

2023

Front. Genet.

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Background: Nrf2 plays a pivotal role in governing the antioxidant defense system, triggering the transcription of diverse genes involved in cellular protection. Its role in mitigating oxidative damage and modulating inflammatory processes has made Nrf2 an attractive target for therapeutic interventions. Despite the growing interest in Nrf2 research, a bibliometric analysis is relatively rare. This study aimed to clarify Nrf2’s role in multiple diseases, identify emerging trends and hotspots using bibliometric analysis, and provide valuable insights and potential directions for future therapeutic interventions.Methods: The Science Citation Index of Web of Science Core library from 2000 to 2022 was searched on 22 October 2022. Use Microsoft Excel, CiteSpace, Bibliometrix, and VOS viewers for data collection and visualization of research focus and trends.Results: A vast collection of 22,040 research studies on Nrf2 published between 2000 and 2022 were identified. Nrf2 research has seen significant growth globally from 2000 to 2022. China leaded in publication numbers (9,623, 43.66%), while the United States dominated in citation frequency with 261,776 citations. China Medical University was the most productive institutions (459, 2.08%). Masayuki Yamamoto topped in publications (307), while Itoh K. ranked first in citations with 3669. Free Radical Biology and Medicine was the journal with the most studies and citations on Nrf2 (613, 29,687 citations). The analysis of keyword clustering enhanced the categorization of topics and can be summarized as oxidative stress, cancer, disorders in glycolipid metabolism, inflammation, and neurological conditions.Conclusion: China and the United States are the pioneers in Nrf2 research. Recently, there has been a comprehensive exploration of Nrf2 involving both experimental and clinical aspects, as well as mechanisms and therapeutic applications. Investigating novel molecular mechanisms, including NF-κB, Ho1, and Keap1, and developing enhanced, targeted Nrf2 activators or inhibitors to uncover the interplay among cancer, glycolipid metabolic disorder, inflammation, and neurological disorders will be upcoming trends and hotspots.

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Section: Discussionmentioning

confidence: 99%

Insight into Nrf2: a bibliometric and visual analysis from 2000 to 2022

Ma,

Wang,

2023

Front. Genet.

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“…Polysaccharides have been considered to be a new natural and effective anti-fatigue substance [ 9 ]. Some natural polysaccharides, such as Semen cassiae ( Cassia obtusifolia L.) [ 14 ], Ganoderma lucidum [ 15 ], Lycium barbarum [ 68 ], Cordyceps militaris [ 69 ], and apple pomace [ 70 ], exert beneficial anti-fatigue effects via different pathways ( Figure 1 ). The monosaccharide composition and the anti-fatigue mechanisms of natural polysaccharides are summarized in Table 1 .…”

Section: Polysaccharides Ameliorate Fatiguementioning

confidence: 99%

“…The anti-fatigue effect of APS-1 is related to its regulation of AMPK and PGC-1α in mouse muscle [ 78 ]. Furthermore, as a typical cellular antioxidant regulator at the transcriptional level, nuclear factor erythroid-derived 2-like 2 (Nrf2) can control the basic and induced expression of a series of antioxidant response element-dependent genes [ 69 , 97 ]. Studies have proven that the activation of the Kelch-like ECH-associated protein 1 (Keap1)/Nrf2/heme oxygenase-1 (HO-1) pathway is the dominant mechanism of cellular defense systems against oxidative stress, and it also participates in enhancing the exercise-induced fatigue state [ 47 , 94 ].…”

Section: Polysaccharides Ameliorate Fatiguementioning

confidence: 99%

“…In similar research, the LBP could ameliorate exercise-induced oxidative stress by regulating the Nrf2/HO-1 pathway and energy metabolism via the AMPK/PGC-1α pathway [ 68 ]. Another study showed that Cordyceps militaris acidic polysaccharides (CMPB) can alleviate exercise fatigue and improve learning and memory of mice by stimulating the expression levels of phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), Nrf2, and HO-1 proteins in the hippocampus [ 69 ]. Moreover, HO-1 can also inhibit the release of pro-inflammatory cytokines [ 3 ].…”

Section: Polysaccharides Ameliorate Fatiguementioning

confidence: 99%

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Dietary Polysaccharides Exert Anti-Fatigue Functions via the Gut-Muscle Axis: Advances and Prospectives

Zhou,

Chu,

Luo

et al. 2023

Foods

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Due to today’s fast-paced lifestyle, most people are in a state of sub-health and face “unexplained fatigue”, which can seriously affect their health, work efficiency, and quality of life. Fatigue is also a common symptom of several serious diseases such as Parkinson’s, Alzheimer’s, cancer, etc. However, the contributing mechanisms are not clear, and there are currently no official recommendations for the treatment of fatigue. Some dietary polysaccharides are often used as health care supplements; these have been reported to have specific anti-fatigue effects, with minor side effects and rich pharmacological activities. Dietary polysaccharides can be activated during food processing or during gastrointestinal transit, exerting unique effects. This review aims to comprehensively summarize and evaluate the latest advances in the biological processes of exercise-induced fatigue, to understand dietary polysaccharides and their possible molecular mechanisms in alleviating exercise-induced fatigue, and to systematically elaborate the roles of gut microbiota and the gut-muscle axis in this process. From the perspective of the gut-muscle axis, investigating the relationship between polysaccharides and fatigue will enhance our understanding of fatigue and may lead to a significant breakthrough regarding the molecular mechanism of fatigue. This paper will provide new perspectives for further research into the use of polysaccharides in food science and food nutrition, which could help develop potential anti-fatigue agents and open up novel therapies for sub-health conditions.

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“…The PI3K/Akt/mTOR signaling pathway is regulated by a variety of conditions such as growth factors, energy deficiency, insulin, hypoxia, and exercise. In addition, Cordyceps acidic polysaccharide modulates the PI3K/Nrf2/HO-1 pathway to exert antioxidant effects on nerve injury, suggesting that PI3K and Nrf2 combine to exert antioxidant effects ( Bai et al, 2023 ).…”

Section: Signaling Pathways Affected By Natural Active Ingredients Ag...mentioning

confidence: 99%

Signaling pathways regulated by natural active ingredients in the fight against exercise fatigue-a review

Zhao,

Wu,

Jin

et al. 2023

Front. Pharmacol.

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Exercise fatigue is a normal protective mechanism of the body. However, long-term fatigue hinders normal metabolism and exercise capacity. The generation and recovery from exercise fatigue involves alterations in multiple signaling pathways, mainly AMPK, PI3K/Akt, Nrf2/ARE, NF-κB, PINK1/Parkin, and BDNF/TrkB, as well as MAPK signaling pathways that mediate energy supply, reduction of metabolites, oxidative stress homeostasis, muscle fiber type switching, and central protective effects. In recent studies, a rich variety of natural active ingredients have been identified in traditional Chinese medicines and plant extracts with anti-fatigue effects, opening up the field of research in new anti-fatigue drugs. In this review we give an overview of the signaling pathways associated with the activity of natural food active ingredients against exercise fatigue. Such a comprehensive review is necessary to understand the potential of these materials as preventive measures and treatments of exercise fatigue. We expect the findings highlighted and discussed here will help guide the development of new health products and provide a theoretical and scientific basis for future research on exercise fatigue.

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Cordyceps militaris acidic polysaccharides improve learning and memory impairment in mice with exercise fatigue through the PI3K/NRF2/HO-1 signalling pathway

Cited by 24 publications

References 35 publications

Insight into Nrf2: a bibliometric and visual analysis from 2000 to 2022

Insight into Nrf2: a bibliometric and visual analysis from 2000 to 2022

Dietary Polysaccharides Exert Anti-Fatigue Functions via the Gut-Muscle Axis: Advances and Prospectives

Signaling pathways regulated by natural active ingredients in the fight against exercise fatigue-a review

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