Cordyceps militaris extracts and cordycepin ameliorate type 2 diabetes mellitus by modulating the gut microbiota and metabolites

Liu, Xinyuan; Dun, Mengqian; Jian, Tongtong; Sun, Yan; Wang, Mingyu; Zhang, Guoying; Ling, Jianya

doi:10.3389/fphar.2023.1134429

Cited by 16 publications

(12 citation statements)

References 37 publications

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“…1) 3-Deoxyarabinohexonic acid, a sugar compound classi ed within the class of organic compounds. 2) Cordycepin (synonyms 3'-Deoxyadenosine), has been reported to possess antidiabetic [14] and antiviral activity [15]. 3) Tri uoperazine: an antipsychotic medication used to treat schizophrenia.…”

Section: Data Descriptionmentioning

confidence: 99%

LC-MS/MS-QTOF dataset of chemical compounds detected in honey samples from Bali and Lombok, Indonesia

ullah,

Hussin,

Huda

et al. 2023

Preprint

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Objective Honey production is susceptible to manipulation by unscrupulous sellers, making honey authentication crucial to prevent fraud. The process of authenticating honey often necessitates the use of various analytical techniques, such as identifying the chemicals present in honey through LC-MS/MS QTOF systems. Therefore, determining the chemical composition in honey is of utmost importance for verifying the authenticity of honey, particularly in the analysis of chemical compound composition from selected location of Bali and Lombok. These samples have not been previously examined using untargeted approaches, representing a novel investigation in this region. Data Description This dataset constitutes a comprehensive compilation of chemical compounds identified in honey samples collected from Bali and Lombok. Employing an untargeted analytical approach, a diverse array of chemical compounds commonly encountered in honey from this geographic region was detected. The dataset includes information regarding compound nomenclature, mass-to-charge ratios, retention times, as well as results from extensive database searches. Collectively, these data afford in-depth insights into the compositional profile of honey samples from this specific geographical area.

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Section: Data Descriptionmentioning

confidence: 99%

LC-MS/MS-QTOF dataset of chemical compounds detected in honey samples from Bali and Lombok, Indonesia

ullah,

Hussin,

Huda

et al. 2023

Preprint

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“…The activity of cordycepin extracted from C. militaris was described in a study on mice, which demonstrated its influence on type 2 diabetes, improving the abundance of Firmicutes/Bacteroides that promote the growth of beneficial bacteria by regulation of the intestinal flora, enhancing the metabolites and metabolic pathways associated with the diabetes type 2 modifications [7].…”

Section: Effects On the Microbiotamentioning

confidence: 99%

“…mushrooms in search of a natural product with high medicinal value. The study of C. mushrooms has shown they have anti-oxidant, anti-inflammatory, hypoglycemic, and anti-tumoral effects [7][8][9][10]. It has also been shown that they can help improve the gut microbiota [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Medicinal Properties of Honey and Cordyceps Mushrooms

Badea,

Vamanu

2023

Nutraceuticals

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In a world still recovering after the COVID-19 pandemic, the consequences of which are still not entirely known, the attention of scientists worldwide is drawn to natural products with positive effects on immunity. The starting point for tackling such a subject is proper documentation of substances used in traditional medicine, which usually have significant nutritional and functional values. Among the most well-known of these substances are mushrooms and honey, both of which have been used for thousands of years all around the globe. The following work aims to gather information about the properties of honey and Cordyceps sp. mushrooms by studying the scientific literature available at this point. With the proper use of this information, it will be possible to develop products that incorporate the studied ingredients to increase their functional and medicinal value.

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“…Previous studies have demonstrated that CM powder exhibited an ability to regulate the immune system in humans [13] and protect mice from triptolide-induced acute hepatotoxicity [12]. Recent studies also highlighted the potential of active constituents from CM to ameliorate type 2 diabetes mellitus, obesity, and neurodegenerative diseases, through modulating gut microbiota and improving intestinal mucosal structure damage [14][15][16]. However, multiple biocomponents of CM may have potential synergistic effects, and it remains unclear whether CM can alleviate UC by regulating the intestinal mucosal barrier and gut microbiota.…”

Section: Introductionmentioning

confidence: 99%

Effect of Cordyceps militaris Powder Prophylactic Supplementation on Intestinal Mucosal Barrier Impairment and Microbiota-Metabolites Axis in DSS-Injured Mice

Wu,

Chen

2023

Nutrients

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Ulcerative colitis (UC) is a chronic and recurrent inflammatory disease with an unknown pathogenesis and increasing incidence. The objective of this study is to investigate the impact of prophylactic treatment with Cordyceps militaris on UC. The findings demonstrate that prophylactic supplementation of C. militaris powder effectively mitigates disease symptoms in DSS-injured mice, while also reducing the secretion of pro-inflammatory cytokines. Furthermore, C. militaris powder enhances the integrity of the intestinal mucosal barrier by up-regulating MUC2 protein expression and improving tight junction proteins (ZO-1, occludin, and claudin 1) in DSS-injured mice. Multiomics integration analyses revealed that C. militaris powder not only reshaped gut microbiota composition, with an increase in Lactobacillus, Odoribacter, and Mucispirillum, but also exerted regulatory effects on various metabolic pathways including amino acid, glyoxylates, dicarboxylates, glycerophospholipids, and arachidonic acid. Subsequent analysis further elucidated the intricate interplay of gut microbiota, the intestinal mucosal barrier, and metabolites, suggesting that the microbiota–metabolite axis may involve the effect of C. militaris on intestinal mucosal barrier repair in UC. Moreover, in vitro experiments demonstrated that peptides and polysaccharides, derived from C. militaris, exerted an ability to change the gut microbiota structure of UC patients’ feces, particularly by promoting the growth of Lactobacillus. These findings suggest that regulatory properties of C. militaris on gut microbiota may underlie the potential mechanism responsible for the protective effect of C. militaris in UC. Consequently, our study will provide support for the utilization of C. militaris as a whole food-based ingredient against the occurrence and development of UC.

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Cordyceps militaris extracts and cordycepin ameliorate type 2 diabetes mellitus by modulating the gut microbiota and metabolites

Cited by 16 publications

References 37 publications

LC-MS/MS-QTOF dataset of chemical compounds detected in honey samples from Bali and Lombok, Indonesia

LC-MS/MS-QTOF dataset of chemical compounds detected in honey samples from Bali and Lombok, Indonesia

Medicinal Properties of Honey and Cordyceps Mushrooms

Effect of Cordyceps militaris Powder Prophylactic Supplementation on Intestinal Mucosal Barrier Impairment and Microbiota-Metabolites Axis in DSS-Injured Mice

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