Cordyceps Militaris improves neurite outgrowth in Neuro2A cells and reverses memory impairment in rats

Lee, Bombi; Park, Jongbong; Park, Jinhee; Shin, Hyun‐Jae; Kwon, Sunoh; Yeom, Mijung; Sur, Bongjun; Kim, Sunghun; Kim, Myung–Hwan; Lee, Hyejung; Yoon, Suk Hoo; Hahm, Dae‐Hyun

doi:10.1007/s10068-011-0221-4

Cited by 25 publications

(12 citation statements)

References 27 publications

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“…Portobello mushroom (Agaricus bisporus), oyster mushroom (Pleurotus ostreatus), elm oyster mushroom (Hypsizygus ulmarius), and tinder fungus (Fomes fomentarius), are more recognized in Western countries [20][21][22]. Other popular mushrooms include Agaricus subrufescens, Coprinus comatus, Hericium erinaceus, Mycoleptodonoides aitchisonii, Phellinus linteus, Schizophyllum commune, and Volvareilla volvacea [23][24][25][26]. There are numerous potential mycochemicals from mushrooms that could be used in cosmeceuticals or nutricosmetics.…”

Section: Mushrooms: Nutritional and Medicinal Factsmentioning

confidence: 99%

Mushroom Cosmetics: The Present and Future

Choi

et al. 2016

Cosmetics

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110

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Abstract:Mushrooms have been valued as a traditional source of natural bioactive compounds for centuries and have recently been exploited for potential components in the cosmetics industry. Numerous mushrooms and their ingredients have been known to be beneficial to the skin and hair. The representative ingredients are as follows: phenolics, polyphenolics, terpenoids, selenium, polysaccharides, vitamins, and volatile organic compounds. These compounds show excellent antioxidant, anti-aging, anti-wrinkle, skin whitening, and moisturizing effects, which make them ideal candidates for cosmetics products. This review provides some perspectives of mushrooms (and/or extracts) and their ingredients presently used, or patented to be used, in both cosmeceuticals for topical administration and nutricosmetics for oral administration. With the small percentage of mushrooms presently identified and utilized, more mushroom species will be discovered, verified, and cultivated in the future, boosting the development of relevant industry. Combining with progress in genomics, proteomics, metabolomics, and systems pharmacology, mushrooms can find their way into cosmetics with multiple approaches.

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Section: Mushrooms: Nutritional and Medicinal Factsmentioning

confidence: 99%

Mushroom Cosmetics: The Present and Future

Choi

et al. 2016

Cosmetics

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110

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“…However, bilberry tended to shorten the time of finding the platform compared to the control of Aβ40-1 and Aβ1-42. Jin et al ( 23 ) observed increasing neuronal survival and enhancing memory in Alzheimer’s disease model rats when Cordyceps militaris L. extracts were administered ( 24 ).…”

Section: Resultsmentioning

confidence: 99%

Vaccinium uliginosum L. Improves Amyloid β Protein-Induced Learning and Memory Impairment in Alzheimer's Disease in Mice

Choi

Kwon

Shin

et al. 2014

JFN

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The present study investigated the effects of Vaccinium uliginosum L. (bilberry) on the learning and memory impairments induced by amyloid-β protein (AβP) 1-42. ICR Swiss mice were divided into 4 groups: the control (Aβ40-1A), control with 5% bilberry group (Aβ40-1B), amyloid β protein 1-42 treated group (Aβ1-42A), and Aβ1-42 with 5% bilberry group (Aβ1-42B). The control was treated with amyloid β-protein 40-1 for placebo effect, and Alzheimer’s disease (AD) group was treated with amyloid β-protein 1-42. Amyloid β-protein 1-42 was intracerebroventricular (ICV) micro injected into the hippocampus in 35% acetonitrile and 0.1% trifluoroacetic acid. Although bilberry added groups tended to decrease the finding time of hidden platform, no statistical significance was found. On the other hand, escape latencies of AβP injected mice were extended compared to that of Aβ40-1. In the Probe test, bilberry added Aβ1-42B group showed a significant (P<0.05) increase of probe crossing frequency compared to Aβ1-42A. Administration of amyloid protein (Aβ1-42) decreased working memory compared to Aβ40-1 control group. In passive avoidance test, bilberry significantly (P<0.05) increased the time of staying in the lighted area compared to AD control. The results suggest that bilberry may help to improve memory and learning capability in chemically induced Alzheimer’s disease in experimental animal models.

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“…These included H . erinaceus [4,35], Sarcodon scabrosus [36], Sarcodon cyrneus [37,38], Termitomyces albuminosus [39,40] and Cordyceps militaris [41]. Shi et al .…”

Section: Discussionmentioning

confidence: 99%

“…The extract of C . militaris stimulated neuritogenesis, enhanced neuronal functions of Neuro2A mouse neuroblastoma cells ( in vitro ) and improved cognitive behaviour that related to memory ability ( in vivo ) [41]. …”

Section: Discussionmentioning

confidence: 99%

Potentiation of neuritogenic activity of medicinal mushrooms in rat pheochromocytoma cells

Seow

Naidu

David

et al. 2013

BMC Complement Altern Med

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BackgroundSenescence of the neurons is believed to be a focal factor in the development of age-related neurodegenerative diseases such as Alzheimer’s disease. Diminutions in the levels of nerve growth factor (NGF) lead to major declines in brain cell performance. Functional foods, believed to mitigate this deficiency, will be reaching a plateau in the near future market of alternative and preventive medicine. In the search for neuroactive compounds that mimic the NGF activity for the prevention of neurodegenerative diseases, the potential medicinal values of culinary and medicinal mushrooms attract intense interest.MethodsCytotoxic effects of aqueous extracts of three medicinal mushrooms basidiocarps, Ganoderma lucidum, Ganoderma neo-japonicum and Grifola frondosa towards rat pheochromocytoma (PC-12) cells were determined by 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The potentiation of neuritogenic activity was assessed by neurite outgrowth stimulation assay. Involvement of cellular signaling pathways, mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK1/2) and phosphoinositide-3-kinase/protein kinase B (PI3K/Akt) in mushrooms-stimulated neuritogenesis were examined by using specific pharmacological inhibitors. Alteration of neuronal morphology by inhibitors was visualized by immunofluorescence staining of the neurofilament.ResultsAll the aqueous extracts tested caused a marked stimulation of neuritogenesis with no detectable cytotoxic effects towards PC-12 cells. The aqueous extract of G. neo-japonicum triggered maximal stimulation of neurite outgrowth at a lower concentration (50 μg/ml) with 14.22 ± 0.43% of neurite-bearing cells, compared to G. lucidum and G. frondosa that act at a higher concentration (75 μg/ml), with 12.61 ± 0.11% and 12.07 ± 0.46% of neurite-bearing cells, respectively. The activation of MEK/ERK1/2 and PI3K/Akt signaling pathways were necessary for the NGF and aqueous extracts to promote neuritogenesis.ConclusionsGanoderma lucidum, G. neo-japonicum and G. frondosa may contain NGF-like bioactive compound(s) for maintaining and regenerating the neuronal communications network. The present study reports the first evidence of the neuritogenic effects of aqueous extracts of basidiocarps of G. neo-japonicum in-vitro and showed the involvement of MEK/ERK1/2 and P13K/Akt signaling pathways for neuritogenesis in PC-12 cells.

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Cordyceps Militaris improves neurite outgrowth in Neuro2A cells and reverses memory impairment in rats

Cited by 25 publications

References 27 publications

Mushroom Cosmetics: The Present and Future

Mushroom Cosmetics: The Present and Future

Vaccinium uliginosum L. Improves Amyloid β Protein-Induced Learning and Memory Impairment in Alzheimer's Disease in Mice

Potentiation of neuritogenic activity of medicinal mushrooms in rat pheochromocytoma cells

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