Cordycerebroside A inhibits ICAM‐1‐dependent M1 monocyte adhesion to osteoarthritis synovial fibroblasts

Lee, Kun-Tsan; Su, Chin-Horng; Liu, Shan‐Chi; Chen, Bo-Cheng; Chang, Jun-Way; Tsai, Cheng-Han; Huang, Wei-Chien; Hsu, Chin‐Jung; Chen, Wei-Cheng; Wu, Yang‐Chang; Tang, Chih‐Hsin

doi:10.1111/jfbc.14108

Cited by 40 publications

(30 citation statements)

References 55 publications

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“…Elevated levels of proinflammatory cytokine expression are found in OA joints [35]. The ACLT animal model for surgical initiation of OA erodes the knee joint cartilage, leading to OA-like disease [6,23]. Here, we found that H. erinaceus mycelium antagonized ACLT-induced promotion of weight-bearing asymmetry, bone loss, synovial inflamma-…”

Section: Discussionmentioning

confidence: 68%

“…Male Sprague-Dawley (SD) rats (eight weeks of age; 300-350 g) were purchased from the National Laboratory Animal Center (Taipei, Taiwan) and randomly divided into three groups: sham surgery (controls), ACLT only and ACLT with H. erinaceus (100 mg/kg). ACLT surgery was performed according to the procedure mentioned in our previous reports [6,23]. Briefly, the rats were anesthetized and underwent arthrotomy to expose the right knee joint, and the ACL was severed.…”

Section: Anterior Cruciate Ligament Transection (Aclt) Animal Modelmentioning

confidence: 99%

“…We examined the effects of H. erinaceus mycelium in a rat model of ACLT [6,23]. As shown in Figure 1, no changes in body weight were observed in the ACLT-only and ACLT + H. erinaceus groups.…”

Section: H Erinaceus Mycelium Reduces Aclt-induced Weight-bearing Asy...mentioning

confidence: 99%

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Hericium erinaceus Mycelium Ameliorates In Vivo Progression of Osteoarthritis

et al. 2022

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Osteoarthritis (OA) is an age-related disorder that affects the joints and causes functional disability. Hericium erinaceus is a large edible mushroom with several known medicinal functions. However, the therapeutic effects of H. erinaceus in OA are unknown. In this study, data from Sprague-Dawley rats with knee OA induced by anterior cruciate ligament transection (ACLT) indicated that H. erinaceus mycelium improves ACLT-induced weight-bearing asymmetry and minimizes pain. ACLT-induced increases in articular cartilage degradation and bone erosion were significantly reduced by treatment with H. erinaceus mycelium. In addition, H. erinaceus mycelium reduced the synthesis of proinflammatory cytokines interleukin-1β and tumor necrosis factor-α in OA cartilage and synovium. H. erinaceus mycelium shows promise as a functional food in the treatment of OA.

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Section: Discussionmentioning

confidence: 68%

Section: Anterior Cruciate Ligament Transection (Aclt) Animal Modelmentioning

confidence: 99%

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Hericium erinaceus Mycelium Ameliorates In Vivo Progression of Osteoarthritis

et al. 2022

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“…Human synovial tissues were stained with anti-CD11b or VCAM-1 antibody and quantified according to the protocol described in our previous work [ 48 , 49 ]. The sum of the intensity and percentage scores was used as the final staining score [ 47 ].…”

Section: Methodsmentioning

confidence: 99%

IL-17 Facilitates VCAM-1 Production and Monocyte Adhesion in Osteoarthritis Synovial Fibroblasts by Suppressing miR-5701 Synthesis

Chang

Lin²,

Lai

et al. 2022

IJMS

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Osteoarthritis (OA) is characterized by the infiltration and adhesion of monocytes into the inflamed joint synovium. Interleukin (IL)-17 is a critical inflammatory mediator that participates in the progression of OA, although the mechanisms linking IL-17 and monocyte infiltration are not well understood. Our analysis of synovial tissue samples retrieved from the Gene Expression Omnibus (GEO) dataset exhibited higher monocyte marker (CD11b) and vascular cell adhesion molecule 1 (VCAM-1) levels in OA samples than in normal, healthy samples. The stimulation of human OA synovial fibroblasts (OASFs) with IL-17 increased VCAM-1 production and subsequently enhanced monocyte adhesion. IL-17 affected VCAM-1-dependent monocyte adhesion by reducing miR-5701 expression through the protein kinase C (PKC)-α and c-Jun N-terminal kinase (JNK) signaling cascades. Our findings improve our understanding about the effect of IL-17 on OA progression and, in particular, VCAM-1 production and monocyte adhesion, which may help with the design of more effective OA treatments.

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“…Allelic discrimination of the SNPs followed previously described assessment procedures 20 - 22 . RNA isolation and RT-qPCR assays followed our previously described procedures 23 - 25 .…”

Section: Methodsmentioning

confidence: 99%

Visfatin Polymorphisms, Lifestyle Risk Factors and Risk of Oral Squamous Cell Carcinoma in a Cohort of Taiwanese Males

et al. 2022

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Oral cancer is the eighth greatest generally diagnosed cancer amongst males worldwide and the fourth most generally malignancy amongst Taiwanese males. The pro-inflammatory adipocytokine visfatin promotes tumor growth. Elevated plasma visfatin levels have been identified in patients with oral squamous cell carcinoma (OSCC), although the biological mechanisms underlying the involvement of visfatin in the pathogenesis of OSCC are not well understood. Moreover, no information is available regarding associations between visfatin polymorphisms and carcinogenic lifestyle factors with OSCC. This study, therefore, investigated the effects of four visfatin gene polymorphisms (rs11977021, rs61330082, rs2110385, and rs4730153) and carcinogenic lifestyle factors (betel nut chewing, alcohol consumption and cigarette smoking) on the risk of developing OSCC in 1,275 Taiwanese males with OSCC, and 1,195 healthy males (controls). We also examined the associations between these visfatin genotypes and OSCC histopathological prognostic factors (pathological stage, tumor status, lymph node status, and metastasis). We found that compared with subjects with the CC genotype of SNP rs11977021, those with the CT+TT genotype were less likely to progress OSCC. In addition, an association was found between the rs4730153 variant and lymph node metastasis in the OSCC cohort.

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Cordycerebroside A inhibits ICAM‐1‐dependent M1 monocyte adhesion to osteoarthritis synovial fibroblasts

Abstract: Kun-Tsan Lee and Chin-Horng Su contributed equally to this work.

Cited by 40 publications

References 55 publications

Hericium erinaceus Mycelium Ameliorates In Vivo Progression of Osteoarthritis

Hericium erinaceus Mycelium Ameliorates In Vivo Progression of Osteoarthritis

IL-17 Facilitates VCAM-1 Production and Monocyte Adhesion in Osteoarthritis Synovial Fibroblasts by Suppressing miR-5701 Synthesis

Visfatin Polymorphisms, Lifestyle Risk Factors and Risk of Oral Squamous Cell Carcinoma in a Cohort of Taiwanese Males

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