The Pandemic has forced change, raising questions about design models, business models, incentives and community education. The urgency of containment measures has redefined the role of health and highlighted the role of Design, which is involved in emergency situations, in designing the universe of protective devices, intervening with Human Centered Design approaches, proposing shared strategies that translate the knowledge and experience of the most advanced research into products. The case study collects the results obtained from the elaboration of the research project financed by the Campania Region, “Smart&Safe. Design for new personal protective equipment” submitted to the call for the acquisition of research and development services for the fight against Covid-19. The research constitutes a substantial study of the problems related to health emergencies and proposes an update in the redesign of Personal Protective Equipment (PPE), now in a plural Intelligent Individual Protection System (IIPS), which determine a relational system of integrated protection.