Core of sensory gating deficits in first-episode schizophrenia: attention dysfunction

Ding, Yushen; Tian, Qing; Hou, Wen-Peng; Chen, Zhenzhu; Mao, Zhen; Bo, Qijing; Dong, Fang; Wang, Chuanyue

doi:10.3389/fpsyt.2023.1160715

Cited by 6 publications

(1 citation statement)

References 66 publications

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“… 9 Using the perceived spatial separation (PSS-PPI) paradigm — whereby the leading ear given background noise is different from the ear receiving the prepulse stimulus — a study found that the PSS-PPI positively correlated with the speed of processing, attention or vigilance and social cognition in unmedicated, first-episode schizophrenia. 25 Among patients with BD, the language domain of the Repeatable Battery for the Assessment of Neuropsychological Status positively correlated with both the PSS-PPI and the perceived spatial co-location (PSC-PPI, in which the leading ear given background noise is the same ear receiving the prepulse stimulus). 26 In the same study, double word time and colour interference time negatively correlated with the PSS-PPI.…”

Section: Introductionmentioning

confidence: 99%

Different levels of prepulse inhibition among patients with first-episode schizophrenia, bipolar disorder and major depressive disorder

Sun,

Bo,

Mao

et al. 2024

jpn

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Background: Deficits in prepulse inhibition may be a common feature in first-episode schizophrenia, bipolar disorder (BD) and major depressive disorder (MDD). We sought to explore the levels and viability of prepulse inhibition to differentiate first-episode schizophrenia, BD and MDD in patient populations. Methods: We tested patients with first-episode schizophrenia, BD or MDD and healthy controls using prepulse inhibition paradigms, namely perceived spatial co-location (PSC-PPI) and perceived spatial separation (PSS-PPI). Results: We included 53 patients with first-episode schizophrenia, 30 with BD and 25 with MDD, as well as 82 healthy controls. The PSS-PPI indicated that the levels of prepulse inhibition were smallest to largest, respectively, in the first-episode schizophrenia, BD, MDD and control groups. Relative to the healthy controls, the prepulse inhibition deficits in the first-episode schizophrenia group were significant ( p < 0.001), but the prepulse inhibitions were similar between patients with BD and healthy controls, and between patients with MDD and healthy controls. The receiver operating characteristic curve analysis showed that PSS-PPI (area under the curve [AUC] 0.73, p < 0.001) and latency (AUC 0.72, p < 0.001) were significant for differentiating patients with first-episode schizophrenia or BD from healthy controls. Limitations: The demographics of the 4 groups were not ideally matched. We did not perform cognitive assessments. The possible confounding effect of medications on prepulse inhibition could not be eliminated. Conclusion: The level of prepulse inhibition among patients with first-episode schizophrenia was the lowest, with levels among patients with BD, patients with MDD and healthy controls increasingly higher. The PSS-PPI paradigm was more effective than PSC-PPI to recognize deficits in prepulse inhibition. These results provide a basis for further research on biological indicators that can assist differential diagnoses in psychosis.

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Section: Introductionmentioning

confidence: 99%