Core outcome set implementation supported by the
            <i>BJD</i>

Veysey, Emma; Ingram, John R.; Apfelbacher, Christian; Drucker, Aaron M.

doi:10.1111/bjd.20050

Cited by 11 publications

(5 citation statements)

References 16 publications

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“…This could be done by journals in the same field working together to promote COS use, as has been done by the CoRe Outcomes in Women's and Newborn health (CROWN) initiative. Journals publishing trial protocols and registered reports are also well placed to endorse use of COS in trials or, at a minimum, require explanations for not using existing COS 23 .…”

Section: Additional Barriers To Cos Use and Reporting In The Current Study Related To Poormentioning

confidence: 99%

Use of core outcome sets was low in clinical trials published in major medical journals

Matvienko‐Sikar

Avery

Blazeby

et al. 2022

Journal of Clinical Epidemiology

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Section: Additional Barriers To Cos Use and Reporting In The Current Study Related To Poormentioning

confidence: 99%

Use of core outcome sets was low in clinical trials published in major medical journals

Matvienko‐Sikar

Avery

Blazeby

et al. 2022

Journal of Clinical Epidemiology

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“…Having sought input from key stakeholders involved in hospital deprescribing for older people under the care of a geriatrician, outcomes within the COS could be measured by organisations that are not undertaking a deprescribing trial but wish to evaluate their deprescribing practices. Challenges to COS implementation include cost/resource requirements of outcome data collection and burden on patients [24][25][26][27]. To support the development of easily implementable COS, identifying how to measure outcomes through assessing the validity, feasibility and acceptability of using a measurement instrument is a recognised stage in COS development [5,[28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Developing a core outcome set for hospital deprescribing trials for older people under the care of a geriatrician

et al. 2022

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Background Half of older people are prescribed unnecessary/inappropriate medications that are not routinely deprescribed in hospital hence there is a need for deprescribing trials. We aimed to develop a Core Outcome Set (COS) for deprescribing trials for older people under the care of a geriatrician during hospital admission. Methods We developed a list of potentially relevant outcomes from the literature. Using a two-round Delphi survey of stakeholder groups representing older people and carers, hospital clinicians, hospital managers, and ageing/deprescribing researchers, each outcome was scored according to Grading of Recommendations Assessment, Development and Evaluation, followed by two consensus workshops to finalise the COS. Results Two hundred people completed Round 1 and 114 completed Round 2. Representing all stakeholder groups, 10 people participated in workshop 1 and 10 in workshop 2. Six outcomes were identified as most important, feasible and acceptable to collect in a trial: number of prescribed medicines stopped; number of prescribed medicines with dosage reduced; quality of life; mortality; adverse drug events and number of hospital stays. Three other outcomes were identified as important, but currently too burdensome to collect: number of potentially inappropriate medicines prescribed; burden from medication routine; and medication-related admissions to hospital. Conclusions A COS represents the minimum outcomes that should be collected and reported. Whilst uncommon practice for COS development, the value of considering outcome collection feasibility is demonstrated by the removal of three potential outcomes that, if included, may have compromised COS uptake due to challenges with collecting the data.

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“…6 At a time when the Core Outcome Measures for Effectiveness Trials group had just started in 2010, such a roadmap was quite innovative in suggesting a clear pathway for COS development including a preference for 1 instrument per domain (what should be measured) and a clear eye toward implementation-a current hot topic in COS research. 35 The roadmap describes 4 steps, starting with identifying the scope and setting with a panel representing all relevant stakeholders and a team experienced in outcomes research. The second step is for the group to consider what core aspects of that disease (domains) must be measured in a clinical trial.…”

Section: General Methodsmentioning

confidence: 99%

“…Although many AD outcome measures have been published, few have met the quality standards required for core outcome selection, so the first challenge is ''less but better.'' Implementation of the COSs according to our roadmap 6,35 is our next major challenge and has been the topic of our virtual HOME IX meeting (September 2021). If no trialists, regulators, funders, systematic reviewers, clinical guideline developers, or journals use the COSs, then the current status quo of not being able to combine and compare trials will prevail.…”

Section: Future Challengesmentioning

confidence: 99%