Core principles of evolutionary medicine

Grunspan, Daniel Z.; Nesse, Randolph M.; Barnes, M. Elizabeth; Brownell, Sara E.

doi:10.1093/emph/eox025

Cited by 69 publications

(67 citation statements)

References 42 publications

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“…Some crucial guidance is now available in a paper just published in Evolution, Medicine and Public Health by Daniel Grunspan et al [1]. In this paper, the authors tackle the challenge of defining core principles in evolutionary medicine by applying the Delphi method, which is a systematic way to build consensus among experts that is especially useful when a diversity of viewpoints and approaches exists.…”

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confidence: 99%

“…Grunspan et al [1] pursued the Delphi method via a panel of 56 experts, using four iterations of a survey that focused on the core principles in evolutionary medicine. They started by offering three different definitions of ‘core principle’, and by asking the experts to ‘list the big ideas that you feel are important in the field of evolutionary medicine’.…”

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confidence: 99%

“…Through four rounds of this general approach (refining the list and specific questions for experts as the research unfolded), the team identified 14 core principles that reached at least 80% agreement, which has been used previously as a mark of ‘consensus’ in the Delphi method. You can find those core principles in the published paper [1], along with levels of consensus, and a list of other concepts that were proposed but failed to reach consensus.…”

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confidence: 99%

“…Grunspan et al ’s [1] paper is a compelling attempt to systematically identify the core principles of evolutionary medicine, and represents an impressive amount of coordination, integration of many responses and deep thought about the breadth of evolutionary medicine research (and how to define core principles in such a broad field). The outcome will be useful for teaching evolutionary medicine courses to undergraduates, and more generally, Grunspan et al ’s [1] contribution helps to define the perspectives and approaches that form the foundations of evolutionary medicine.…”

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confidence: 99%

“…The outcome will be useful for teaching evolutionary medicine courses to undergraduates, and more generally, Grunspan et al ’s [1] contribution helps to define the perspectives and approaches that form the foundations of evolutionary medicine.…”

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confidence: 99%

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A roadmap for ‘core concepts’ in evolutionary medicine

Nunn

2018

Evolution, Medicine, and Public Health

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mentioning

confidence: 99%

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confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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A roadmap for ‘core concepts’ in evolutionary medicine

Nunn

2018

Evolution, Medicine, and Public Health

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Evolutionary Medicine

Dolgova¹

2021

Encyclopedia of Life Sciences

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Evolutionary medicine is a fast‐growing research field providing biomedical scientists with evolutionary perspective for the comprehension of the human health and disease as a result of evolutionary processes, such as selective constraints, trade‐offs, conflicts between different systems within the same organism and mismatches between our modern lives and the environment where human beings evolve. The present human genome and phenotypes are essentially Palaeolithic: they are not adapted to the modern lifestyle, thus favouring the so‐called diseases of civilization. Molecular evolution has helped to revolutionise our understanding of cancer, of autoimmune disease, and of the origin, spread, and pathogenesis of emerging diseases, emotional disruptive behaviour and mental diseases, where it has revealed historical processes and suggested new therapies. An evolutionary perspective of medicine works as a comprehensive scaffolding for organising medical principles and ideas (as it does in biology in general) that otherwise would remain unconnected. Key Concepts Evolutionary medicine studies the dynamic consequences of natural selection acting on the human lineage and underlying human health and disease. Originated from Darwinian Evolutionary Theory, Evolutionary medicine has undergone an exponential growth since the early 1990s providing a comprehensive framework, which places medical principles and ideas within evolutionary context. The complex genetic diseases within evolutionary perspective can be explained by evolutionary conflicts, mismatches between genotypes and modern environment, trade‐offs as a result of evolutionary innovations and selective constraints. Evolutionary perspective can provide us with therapeutic targets for exclusively human diseases, especially for diseases in which evolutionary mechanisms act over short time periods. Evolutionary framework needs to be integrated into the precision medicine to complex pathologies, accounting for the life history of human populations.

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Neutral theory and beyond: A systematic review of molecular evolution education

Forsythe

Hsu

2023

Ecology and Evolution

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Molecular evolution—including the neutral theory of molecular evolution—is a major sub‐discipline of evolution and is widely taught in undergraduate evolution courses. However, despite its ubiquity, there have not been any previous attempts to compile and review the molecular evolution education literature. Here, we draw upon the framework proposed in a past literature review examining the broader evolution education landscape to conduct a literature review of papers related to molecular evolution education, classifying the contributions of such papers to evolution pedagogy as well as evolution education research. We find that there remains very limited coverage of molecular evolution in the education literature, with existing papers focusing primarily on providing new instructional modules and strategies for teaching molecular evolution. Our work suggests several areas of critical need as well as opportunities to advance evolution education and evolution education research, including compiling instructional goals for the sub‐discipline, developing validated assessments, and investigating student thinking related to molecular evolution. We conclude by providing general strategies, advice, and a novel curricular activity for teaching molecular evolution and the neutral theory of molecular evolution.

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Core principles of evolutionary medicine

Cited by 69 publications

References 42 publications

A roadmap for ‘core concepts’ in evolutionary medicine

A roadmap for ‘core concepts’ in evolutionary medicine

Evolutionary Medicine

Neutral theory and beyond: A systematic review of molecular evolution education

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