Core/shell cellulose‐based microspheres for oral administration of Ketoprofen Lysinate

Abstract

Herein, we propose the fabrication of a new carrier with core/shell structure-inner core of cellulose acetate (CA) coated by a micrometric layer of chitosan (CS)-fabricated through an integrated process, which combines Electro Dynamic Atomization (EDA) and layer-by-layer (LbL) technique. We demonstrate that CA based microspheres possess a unique capability to relevantly retain the drugs-that is, Ketoprofen Lysinate (KL)-along the gastric tract, while providing a massive release along the intestine. CS shell slightly influences the morphology and water retention under different pH conditions, improving drug encapsulation without compromising drug release kinetics. In vitro studies in simulated gastric and intestine fluids (SGF, SIF) with physiological enzymes, show a moderate release of LSK during the first 2 h (ca. 20% at pH 2), followed by a sustained release during the next 6 h (ca. 80% at pH 7). The obtained results demonstrate that CA-based microspheres hold strong potential to be used as carriers for a delayed oral administration of anti-inflammatory drugs. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2636-2644, 2018.

The Relationships between the Working Fluids, Process Characteristics and Products from the Modified Coaxial Electrospinning of Zein

“…It has proven to be possible to perform the electrospinning process even when one or more of the working fluids cannot on its own be processed: For instance, in modified coaxial electrospinning, a spinnable core solution is partnered with an unspinnable sheath fluid. These novel processes permit the production of nanofibers with increasingly complicated nanostructures [32,33,34,35,36,37]. As a result, in the literature, there are numerous publications that explore the influence of a single parameter on the nanofibers or nanostructures prepared by electrospinning, elucidating relationships for manipulating the products (mainly in terms of diameter, but also for other properties such as morphology, surface smoothness and the details of the nanostructure) [38,39,40,41,42,43].…”

Mono- and Bi-Phasic Cellulose Acetate Micro-Vectors for Anti-Inflammatory Drug Delivery

“…This has allowed the containment of capsule elongation, also influencing specific functionalities for a controlled release of anti-inflammatory drugs. Recent studies have demonstrated the versatility and high feasibility of the EHDA process to particularize properties and functions of micro-sized devices by the easy customization of the process setup configuration, in order to obtain tailored systems for different applications in biomedical areas (i.e., regenerative medicine, drug delivery, bio-cosmetics, bio-packaging) [17,24] that are easily scalable for industrial production [25].…”

“…In vitro release tests were conducted onto KL-loaded systems in simulated biological fluids, simulating different pH conditions along the gastro-digestive tract. Hence, simulated gastric fluids (SGF) and intestinal fluids (SIF) were prepared according to the European guidelines of pharmacopoeia, in accordance with previous studies [17]. Samples were placed into 1 mL of medium and incubated at 37 °C under shaking.…”

Cellulose–Silver Composites Materials: Preparation and Applications

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