Core–shell gold nanorod@mesoporous-MOF heterostructures for combinational phototherapy

Abstract

A core–shell heterostructure consisting of plasmonic gold nanorods and porphyrinic metal–organic frameworks is synthesized as a promising platform to combine photodynamic therapy and photothermal therapy for enhanced tumor treatment.

Metal–organic framework combined with CaO2 nanoparticles for enhanced and targeted photodynamic therapy

“…The redshift was attributed to the enlarged conjugated area of porphyrin after the formation of the PCN-224, which was in accordance to the reported literature. [43] Importantly, CaO PCN-224-CaO 2 -HA was found to accumulate effectively at the tumor site after 12 h of intravenous administration, which was attributed to the enhanced permeability and retention effect 44 and HA mediated targeting accumulation of the therapeutic agent (Fig. 6a and 6b).…”

Advances in antitumor nanomedicine based on functional metal–organic frameworks beyond drug carriers

“…9d). 143 The porphyrin MOF is composed of Zr 4+ and TCPP. The TEM image showed that the AuNRs are surrounded by spindle MOFs, forming a core-shell heterostructure with an average size of about 102.7 Â 186.8 nm.…”

Gold nanoparticles (GNPs) in biomedical and clinical applications: A review

“…The PTT mechanism works by increasing tumor micro‐environment temperature by exploiting GNP's light to heat conversion properties which induce apoptosis and/or necrosis of the tumor cells. Several gold nanostructures such as gold nanorod, [ 271 ] nanocages, [ 272 ] nanostars, [ 273 ] nanoshells [ 274 ] were reported to be effective for PTT mediated cancer therapy. Gold shell nanoparticles (GS‐NPs), which are made up of a silica core and a gold shell with a diameter of about 150 nm, can absorb light in the near‐infrared (NIR) range and then convert the photon energy to heat.…”