Core Shell Investigation of 2-nitroimidazole

Bolognesi, P.; Carravetta, Vincenzo; Sementa, Luca; Barcaro, Giovanni; Monti, Susanna; Mishra, P M; Cartoni, Antonella; Castrovilli, Mattea Carmen; Chiarinelli, Jacopo; Tosic, Sanja; Marinković, B P; Richter, R.; Avaldi, L.

doi:10.3389/fchem.2019.00151

Cited by 8 publications

(10 citation statements)

References 53 publications

(84 reference statements)

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“…The sequence of the next three exothermic peaks with maxima at 403 °C, 440 °C and 465 °C was associated with the vaporization of the gas mixture resulting from thermal decomposition, especially elemental sulfur. This hypothesis is supported by the boiling point of sulfur being 444.6 °C [ 37 , 38 , 39 ]. Figure 8 c shows the thermal behavior of the AZA after UV irradiation.…”

Section: Resultsmentioning

confidence: 99%

“…Over the range from 123 °C to 140 °C, there is a large mass loss (~17.1%) accompanied by an endothermic peak centered at 137 °C. This effect can be assigned to thermal degradation of ST [ 37 , 38 , 39 ]. Due to the fact that the sample was analyzed in synthetic air, in the sequence of reactions specific to the thermal decomposition of Na 2 S 2 O 3 , an oxidizing effect of the released sulfur may also occur.…”

Section: Resultsmentioning

confidence: 99%

“…Due to the fact that the sample was analyzed in synthetic air, in the sequence of reactions specific to the thermal decomposition of Na 2 S 2 O 3 , an oxidizing effect of the released sulfur may also occur. The endothermic peak at 335 °C can be assigned to such a process [ 37 , 38 , 39 ]. The sequence of the next three exothermic peaks with maxima at 403 °C, 440 °C and 465 °C was associated with the vaporization of the gas mixture resulting from thermal decomposition, especially elemental sulfur.…”

Section: Resultsmentioning

confidence: 99%

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Photodegradation of Azathioprine in the Presence of Sodium Thiosulfate

Toulbe

Smaranda

Negrilă

et al. 2022

IJMS

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The effect of sodium thiosulfate (ST) on the photodegradation of azathioprine (AZA) was analyzed by UV-VIS spectroscopy, photoluminescence (PL), FTIR spectroscopy, Raman scattering, X-ray photoelectron (XPS) spectroscopy, thermogravimetry (TG) and mass spectrometry (MS). The PL studies highlighted that as the ST concentration increased from 25 wt.% to 75 wt.% in the AZA:ST mixture, the emission band of AZA gradual downshifted to 553, 542 and 530 nm. The photodegradation process of AZA:ST induced: (i) the emergence of a new band in the 320–400 nm range in the UV-VIS spectra of AZA and (ii) a change in the intensity ratio of the photoluminescence excitation (PLE) bands in the 280–335 and 335–430 nm spectral ranges. These changes suggest the emergence of new compounds during the photo-oxidation reaction of AZA with ST. The invoked photodegradation compounds were confirmed by studies of the Raman scattering, the FTIR spectroscopy and XPS spectroscopy through: (i) the downshift of the IR band of AZA from 1336 cm−1 to 1331 cm−1, attributed to N-C-N deformation in the purine ring; (ii) the change in the intensity ratio of the Raman lines peaking at 1305 cm−1 and 1330 cm−1 from 3.45 to 4.57, as the weight of ST in the AZA:ST mixture mass increased; and (iii) the emergence of a new band in the XPS O1s spectrum peaking at 531 eV, which was associated with the C=O bond. Through correlated studies of TG-MS, the main key fragments of ST-reacted AZA are reported.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Photodegradation of Azathioprine in the Presence of Sodium Thiosulfate

Toulbe

Smaranda

Negrilă

et al. 2022

IJMS

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“…Attosecond laser technology has already proven to trace the electronic dynamics in small atoms and molecules, while for large molecules such as those involved in biological processes (photosynthesis, radiation damage, etc.) [77][78][79][80][81][82], the study is still in its infancy. Usually, attosecond pump-probe spectroscopy is used to study electron dynamics with a temporal resolution of a few femtoseconds and sub-femtoseconds [83][84][85][86].…”

Section: Ultrafast Reaction Dynamicsmentioning

confidence: 99%

Perspectives of Gas Phase Ion Chemistry: Spectroscopy and Modeling

et al. 2022

Self Cite

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The study of ions in the gas phase has a long history and has involved both chemists and physicists. The interplay of their competences with the use of very sophisticated commercial and/or homemade instrumentations and theoretical models has improved the knowledge of thermodynamics and kinetics of many chemical reactions, even if still many stages of these processes need to be fully understood. The new technologies and the novel free-electron laser facilities based on plasma acceleration open new opportunities to investigate the chemical reactions in some unrevealed fundamental aspects. The synchrotron light source can be put beside the FELs, and by mass spectrometric techniques and spectroscopies coupled with versatile ion sources it is possible to really change the state of the art of the ion chemistry in different areas such as atmospheric and astro chemistry, plasma chemistry, biophysics, and interstellar medium (ISM). In this manuscript we review the works performed by a joint combination of the experimental studies of ion–molecule reactions with synchrotron radiation and theoretical models adapted and developed to the experimental evidence. The review concludes with the perspectives of ion–molecule reactions by using FEL instrumentations as well as pump probe measurements and the initial attempt in the development of more realistic theoretical models for the prospective improvement of our predictive capability.

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“…Oxygen mimetics on the other hand may penetrate the tumour further than oxygen, proving valuable in hypoxia-targeted radiotherapy. Dissociation dynamics of various nitroimidazole compounds have been studied actively in recent years, [5][6][7][8][9][10][11] and special attention has been given to release of radicals and fragments related to the nitro group. In particular, neutral NO radicals have strongly been associated with radiosensitization.…”

Section: Introductionmentioning

confidence: 99%