Core–shell La _{1− x} Sr _x MnO ₃ nanoparticles as colloidal mediators for magnetic fluid hyperthermia

Abstract

Core-shell nanoparticles consisting of La 0.75 Sr 0.25 MnO 3 cores covered by silica were synthesized by a procedure consisting of several steps, including the sol-gel method in the presence of citric acid and ethylene glycol, thermal and mechanical treatment, encapsulation employing tetraethoxysilane and final separation by centrifugation in order to get the required size fraction. Morphological studies revealed well-separated particles that form a stable water suspension. Magnetic studies include magnetization measurements and investigation of the ferromagnetic-superparamagnetic-paramagnetic transition. Magnetic heating experiments in 'calorimetric mode' were used to determine the heating efficiency of the particles in water suspension and further employed for biological studies of extracellular and intracellular effects analysed by tests of viability.

Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies

“…4,5 Thus, hyperthermia can destroy the tumor tissues while sparing the healthy ones. 5,6 However, it is often not possible to heat the tumor cells selectively as conventional hyperthermia involves applying heat to the entire body. 7 To overcome this difficulty, magnetic nanoparticles (MNP)-mediated hyperthermia, which results in localized heating, is being developed as a method of choice.…”

Temperature-dependent and time-dependent effects of hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3: in vitro studies

“…1 These high temperatures are reported to kill cancerous cells selectively and are thus useful in treating several types of cancer. [2][3][4] This effect is because of irregular and poor blood flow in the tumor that allows slow dissipation of heat, making cancerous cells more thermosensitive than normal cells. 5 Taking advantage of this differential thermotolerance, whole body hyperthermia is used clinically to treat cancer.…”

Synthesis of ferromagnetic La1−x Sr x MnO3 nanoparticles by precipitation from diethylene glycol solution and their properties

“…The value of specific loss power (SLP) was calculated on the basis of these results and it is 14.7 W/g. After comparing La 1x Sr x MnO 3 nanoparticles synthesized by precipitation from diethylene glycol solution with nanoparticles obtained by sol-gel method [15,27], it should be mentioned that there are no "bridge" bonds between individual particles, i.e., they are weakly agglomerated ( Fig. 6(2)).…”

“…When (Fig. 6(2)), particles obtained by sol-gel method [15,27] agglomerate due to the formation of the so-called "bridges" between individual nanoparticles.…”