Core-shell microneedle patch for six-month controlled-release contraceptive delivery

Li, Wei; Chen, Jonathan Yuxuan; Terry, Richard N.; Tang, Jie; Romanyuk, Andrey; Schwendeman, Steven P.; Prausnitz, Mark R.

doi:10.1016/j.jconrel.2022.04.051

Cited by 50 publications

(20 citation statements)

References 48 publications

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“…Given the dependence on lithographic methods, it is evident that the geometries that can be achieved for this design are limited as well. 54 Li et al 55 developed a more complex MAP design that incorporates a poly(L-lactic acid) (PLLA) shell, encapsulating a poly(lactic-co-glycolic acid) (PLGA) core containing the contraceptive hormone levonorgestrel. The shell is meant to be a mechanism for controlling dissolution rate to achieve zero-order, or linear, drug release kinetics.…”

Section: Current Landscape Of Map Geometriesmentioning

confidence: 99%

“…Subsequently, the PLGA + levonorgestrel core is added and capped with PLLA and placed on a PVA/sucrose backing (Figure B). The needles were conical in shape with a base radius of 150 μm and a height of 600 μm . This design was able to achieve sustained release of levonorgestrel for 180 days, in a linear fashion.…”

Section: Map Developmentmentioning

confidence: 99%

Section: Map Developmentmentioning

confidence: 99%

“…The needles were conical in shape with a base radius of 150 μm and a height of 600 μm. 55 This design was able to achieve sustained release of levonorgestrel for 180 days, in a linear fashion. Despite the promise for sustained delivery at large time scales, the process to generate these MAPs is still multistep, leading to simple, uniform geometries across the patch.…”

Section: Map Developmentmentioning

confidence: 99%

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3D-Printed Microarray Patches for Transdermal Applications

Rajesh

Coates

Driskill

et al. 2022

JACS Au

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The intradermal (ID) space has been actively explored as a means for drug delivery and diagnostics that is minimally invasive. Microneedles or microneedle patches or microarray patches (MAPs) are comprised of a series of micrometer-sized projections that can painlessly puncture the skin and access the epidermal/dermal layer. MAPs have failed to reach their full potential because many of these platforms rely on dated lithographic manufacturing processes or molding processes that are not easily scalable and hinder innovative designs of MAP geometries that can be achieved. The DeSimone Laboratory has recently developed a high-resolution continuous liquid interface production (CLIP) 3D printing technology. This 3D printer uses light and oxygen to enable a continuous, noncontact polymerization dead zone at the build surface, allowing for rapid production of MAPs with precise and tunable geometries. Using this tool, we are now able to produce new classes of lattice MAPs (L-MAPs) and dynamic MAPs (D-MAPs) that can deliver both solid state and liquid cargos and are also capable of sampling interstitial fluid. Herein, we will explore how additive manufacturing can revolutionize MAP development and open new doors for minimally invasive drug delivery and diagnostic platforms.

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Section: Current Landscape Of Map Geometriesmentioning

confidence: 99%

Section: Map Developmentmentioning

confidence: 99%

Section: Map Developmentmentioning

confidence: 99%

Section: Map Developmentmentioning

confidence: 99%

See 2 more Smart Citations

3D-Printed Microarray Patches for Transdermal Applications

Rajesh

Coates

Driskill

et al. 2022

JACS Au

View full text Add to dashboard Cite

show abstract

“…[7][8][9][10] In contrast to other methods currently used for personalized drug delivery, MNPs could be produced in different shapes and tunable dimensions and could be selfadministered. [11][12][13][14][15][16] In a previous study, Donnelly et al developed a dissolving poly(vinyl alcohol) microneedle array for the rapid delivery of Nestorone, which could attain a maximum blood concentration (C max of 32 ± 14 ng mL −1 ) within one hour of skin penetration. 17 In another study, Guo et al used a gelatin/hyaluronic acid particle mixture to load long-acting insulin, which achieved the successful long-term delivery of insulin to address increasing blood glucose levels and effectively reduced fluctuations.…”

Section: Introductionmentioning

confidence: 99%

Personalized demand-responsive biphasic microneedle patch for smart drug administration

Deng¹,

Yao²,

Zhang³

et al. 2023

Biomater. Sci.

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Sponge‐Like Microneedles Spatially Sequester Chemokines and Deplete Monocytes to Alleviate Inflammatory Skin Disorders

Le,

Shou,

et al. 2024

Adv Funct Materials

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Persistent inflammation, characterized by the intense interplay of inflammatory chemokine secretion and immune cell infiltration, is a hallmark of many skin disorders including diabetic wounds and psoriasis with inadequate therapeutic interventions. Monocyte chemotactic protein‐1 (MCP‐1) is an inflammatory chemokine that plays a key role in recruiting and polarizing monocytes into pro‐inflammatory macrophages to establish a vicious cycle that worsens the inflamed tissue microenvironment. Here, the sponge‐like microneedles (HPMN) technology is described to alleviate inflammatory skin disorders. Heparin/4‐arm PEG‐NH2 network crosslinked onto microneedle surface spatially attracted and sequestered multiple inflammatory chemokines including MCP‐1. Enrichment of MCP‐1 on microneedles recruits and traps inflammatory monocytes within the porous structure of microneedles. Subsequent removal of microneedles not only depletes inflammatory chemokine, MCP‐1, but also its cellular source. As a result, HPMN treatment facilitates 47.1% smaller open wound area in mice and 27.2% shorter wound length in pigs. To demonstrate the versatility of the HPMN technology, it is also shown that combining the method with standard‐of‐care immunosuppressants reduces 45.1% epidermis thickening and attenuated immune cell influx in a mouse psoriasis model. Overall, the HPMN technology is a novel demonstration of employing inflammatory chemokine and cell extraction to treat a broad range of inflammatory skin disorders.

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Core-shell microneedle patch for six-month controlled-release contraceptive delivery

Cited by 50 publications

References 48 publications

3D-Printed Microarray Patches for Transdermal Applications

3D-Printed Microarray Patches for Transdermal Applications

Personalized demand-responsive biphasic microneedle patch for smart drug administration

Sponge‐Like Microneedles Spatially Sequester Chemokines and Deplete Monocytes to Alleviate Inflammatory Skin Disorders

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