Core–shell structured carbon dots with up-conversion fluorescence and photo-triggered nitric oxide-releasing properties

Wu, Xiaoyan; Wang, Meiyan; Yu, Feng; Cai, Hao; Tedesco, Antonio Claudio; Li, Zijian; Bi, Hong

doi:10.1039/d3an02034g

Analyst

2024

DOI: 10.1039/d3an02034g

|View full text |Cite

Core–shell structured carbon dots with up-conversion fluorescence and photo-triggered nitric oxide-releasing properties

Xiaoyan Wu,

Meiyan Wang,

Feng Yu

et al.

Abstract: Cancer-targeted nanotechnology has a new trend to design and prepare new materials with functions for imaging and therapeutic applications simultaneously. As a new type of carbon nanomaterials, the inherent core-shell...

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Direct and indirect approaches to red-shift photoactivated nitric oxide release

Elbeheiry,

Schulz

2024

Coordination Chemistry Reviews

View full text Add to dashboard Cite

Direct and indirect approaches to red-shift photoactivated nitric oxide release

Elbeheiry,

Schulz

2024

Coordination Chemistry Reviews

View full text Add to dashboard Cite

Nitric Oxide-Photodelivering Materials with Multiple Functionalities: From Rational Design to Therapeutic Applications

Parisi,

Laneri,

Martins

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

The achievement of materials that are able to release therapeutic agents under the control of light stimuli to improve therapeutic efficacy is a significant challenge in health care. Nitric oxide (NO) is one of the most studied molecules in the fascinating realm of biomedical sciences, not only for its crucial role as a gaseous signaling molecule in the human body but also for its great potential as an unconventional therapeutic in a variety of diseases including cancer, bacterial and viral infections, and neurodegeneration. Handling difficulties due to its gaseous nature, reduced region of action due to its short half-life, and strict dependence of the biological effects on its concentration and generation site are critical questions to be solved for appropriate therapeutic uses of NO. Light-activatable NO precursors, namely, NO photodonors (NOPDs), address the above issues since they are stable in the dark and permit in a noninvasive fashion the remote-controlled delivery of NO on demand with great spatiotemporal precision. Engineering biocompatible materials with NOPDs and their combination with additional imaging, therapeutic, and phototherapeutic components leads to intriguing light-responsive multifunctional constructs exhibiting promising potential for biomedical applications. This contribution illustrates the most significant progress made over the last five years in achieving engineered materials including nanoparticles, gels, and thin films, sharing the common feature to deliver NO under the exclusive control of the biocompatible visible/near infrared light inputs. We will highlight the logical design behind the fabrication of these systems, illustrating the potential therapeutic applications with particular emphasis on cancer and bacterial infections.

show abstract

Nitric oxide-based multi-synergistic nanomedicine: an emerging therapeutic for anticancer

Tang,

Li,

Zhou

et al. 2024

J Nanobiotechnol

View full text Add to dashboard Cite

Gas therapy has emerged as a promising approach for treating cancer, with gases like NO, H 2 S, and CO showing positive effects. Among these, NO is considered a key gas molecule with significant potential in stopping cancer progression. However, due to its high reactivity and short half-life, delivering NO directly to tumors is crucial for enhancing cancer treatment. NO-driven nanomedicines (NONs) have been developed to effectively deliver NO donors to tumors, showing great progress in recent years. This review provides an overview of the latest advancements in NO-based cancer nanotherapeutics. It discusses the types of NO donors used in current research, the mechanisms of action behind NO therapy for cancer, and the different delivery systems for NO donors in nanotherapeutics. It also explores the potential of combining NO donors with other treatments for enhanced cancer therapy. Finally, it examines the future prospects and challenges of using NONs in clinical settings for cancer treatment. Graphical Abstract

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Core–shell structured carbon dots with up-conversion fluorescence and photo-triggered nitric oxide-releasing properties

Abstract: Cancer-targeted nanotechnology has a new trend to design and prepare new materials with functions for imaging and therapeutic applications simultaneously. As a new type of carbon nanomaterials, the inherent core-shell...

Cited by 3 publications

References 43 publications

Direct and indirect approaches to red-shift photoactivated nitric oxide release

Direct and indirect approaches to red-shift photoactivated nitric oxide release

Nitric Oxide-Photodelivering Materials with Multiple Functionalities: From Rational Design to Therapeutic Applications

Nitric oxide-based multi-synergistic nanomedicine: an emerging therapeutic for anticancer

Contact Info

Product

Resources

About