Core-stabilized polymeric micelle as potential drug carrier: increased solubilization of taxol

Synthesis and Characterization of Biodegradable Amphiphilic Star and Y-Shaped Block Copolymers as Potential Carriers for Vinorelbine

“…Star-shaped block copolymers with a core consisting of hydrophobic inner branches and multiple hydrophilic poly(ethylene glycol) (PEG) tails have been synthesized in the range of 3 to 32 by Wang et al [7,8], Zheng et al [9] and some other groups [10][11][12][13][14][15][16]. The unimers with arm numbers of 16 or 32 have shown the high stability, drug delivery efficacy and physicochemical properties compared to unimers with a smaller arm number.…”

Novel Biodegradable Polylactide/poly(ethylene glycol) Micelles Prepared by Direct Dissolution Method for Controlled Delivery of Anticancer Drugs

“…It has been widely used for the treatment of various tumors, such as ovarian cancer, metastatic breast cancer, non-small cell lung cancer, head and neck malignancies and other cancers (1)(2)(3)(4)(5). However, the clinical application of paclitaxel is limited by its poor aqueous solubility, which is below 0.5 μg/ml (6)(7)(8). A co-solvent formulation consisting of 50:50 Cremophor EL and dehydrated alcohol has been used for its clinical administration, called Taxol®.…”

Synthesis, characterization, and evaluation of mPEG–SN38 and mPEG–PLA–SN38 micelles for cancer therapy

“…[19][20][21] Methoxy poly(ethylene glycol)-b-poly(lactide) (mPEG-PLA) is an amphiphilic block copolymer that can self-assemble into a micelle, which has a hydrophobic PLA core and a hydrophilic mPEG shell. [22][23][24] Hydrophobic drugs can be incorporated into the PLA core. Meanwhile, the hydrophilic mPEG shell can reduce clearance of the micelles by the mononuclear phagocyte system.…”