Corécepteurs lymphocytaires

Olive, Daniel

doi:10.1051/medsci/200622121069

Cited by 5 publications

(3 citation statements)

References 31 publications

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“…CTLA4, like PDCD1, is a negative regulator of T-cell activation [32], and polymorphisms in this gene are associated with the onset of GD [33], [34]. Studies report that CTLA4 and PDCD1 act as co-inhibitors of T-cell proliferation and activation [35], [36]. This functional association between PDCD1 and CTLA4 explains the relationship between PDCD1 and GD, and indicates that the CoPub Discovery predicted association between PDCD1 and GD was correctly identified based on biological knowledge.…”

Section: Resultsmentioning

confidence: 78%

Literature Mining for the Discovery of Hidden Connections between Drugs, Genes and Diseases

Frijters

Vugt²,

Smeets³

et al. 2010

PLoS Comput Biol

149

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The scientific literature represents a rich source for retrieval of knowledge on associations between biomedical concepts such as genes, diseases and cellular processes. A commonly used method to establish relationships between biomedical concepts from literature is co-occurrence. Apart from its use in knowledge retrieval, the co-occurrence method is also well-suited to discover new, hidden relationships between biomedical concepts following a simple ABC-principle, in which A and C have no direct relationship, but are connected via shared B-intermediates. In this paper we describe CoPub Discovery, a tool that mines the literature for new relationships between biomedical concepts. Statistical analysis using ROC curves showed that CoPub Discovery performed well over a wide range of settings and keyword thesauri. We subsequently used CoPub Discovery to search for new relationships between genes, drugs, pathways and diseases. Several of the newly found relationships were validated using independent literature sources. In addition, new predicted relationships between compounds and cell proliferation were validated and confirmed experimentally in an in vitro cell proliferation assay. The results show that CoPub Discovery is able to identify novel associations between genes, drugs, pathways and diseases that have a high probability of being biologically valid. This makes CoPub Discovery a useful tool to unravel the mechanisms behind disease, to find novel drug targets, or to find novel applications for existing drugs.

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Section: Resultsmentioning

confidence: 78%

Literature Mining for the Discovery of Hidden Connections between Drugs, Genes and Diseases

Frijters

Vugt²,

Smeets³

et al. 2010

PLoS Comput Biol

149

View full text Add to dashboard Cite

show abstract

“…The CD40LG–CD40 interaction is a co-stimulatory pathway that activates T-cells and antigen-presenting cells (APCs) [58,59], and CD40LG blocks apoptosis [31]. The decrease in CD40LG expression would reduce the CD40LG–CD40 interaction between the Jurkat T-cells and NK cells, allowing inhibitory pathways, such as PDL1 and PDL2 [60,61], to shift the balance in favor of T-cell apoptosis and decreased tumor burden.…”

Section: Discussionmentioning

confidence: 99%

Effects of parathyroid hormone-related protein and macrophage inflammatory protein-1α in Jurkat T-cells on tumor formationin vivoand expression of apoptosis regulatory genesin vitro

Shu

Dirksen²,

Lanigan³

et al. 2012

Leukemia & Lymphoma

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Parathyroid hormone-related protein (PTHrP) and macrophage inflammatory protein-1α (MIP-1α) have been implicated in the pathogenesis of adult T-cell leukemia/lymphoma, but their effects on T-cells have not been well studied. Here we analyzed the functions of PTHrP and MIP-1α on T-cell growth and death both in vitro and in vivo by overexpressing either factor in human Jurkat T-cells. PTHrP or MIP-1α did not affect Jurkat cell growth in vitro, but PTHrP increased their sensitivity to apoptosis. Importantly, PTHrP and MIP-1α decreased both tumor incidence and growth in vivo. To investigate possible mechanisms, polymerase chain reaction (PCR) arrays and real-time reverse transcription (RT)-PCR assays were performed. Both PTHrP and MIP-1α increased the expression of several factors including signal transducer and activator of transcription 4, tumor necrosis factor α, receptor activator of nuclear factor κB ligand and death-associated protein kinase 1, and decreased the expression of inhibitor of DNA binding 1, interferon γ and CD40 ligand in Jurkat cells. In addition, MIP-1α also increased the expression of transcription factor AP-2α and PTHrP increased expression of the vitamin D3 receptor. These data demonstrate that PTHrP and MIP-1α exert a profound antitumor effect presumably by increasing the sensitivity to apoptotic signals through modulation of transcription and apoptosis factors in T-cells.

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“…Cette protéine de 51 kDa référencée sous le nom DKFZp686O24166 a pour proches homologues B7-H1 et B7-H3, deux membres de la famille B7. L'organisation de DKFZp686O24166 est semblable à celle des membres de cette famille B7 [10] puisque c'est une protéine transmembranaire de type I possédant deux domaines immunoglobuline (Ig) dans sa partie extracellulaire qui sont codés par deux exons séparés par un intron en phase 1. Parallèlement, NKp30 présente une homologie avec CTLA-4, le récep-teur des deux membres fondateurs de la famille B7.…”

Section: B7-h6 Un Nouveau Ligand De Nkp30unclassified

B7-H6 : un nouveau signal d’alarme pour les cellulesnatural killer

Baratin

Vivier

2010

Med Sci (Paris)

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Corécepteurs lymphocytaires

Cited by 5 publications

References 31 publications

Literature Mining for the Discovery of Hidden Connections between Drugs, Genes and Diseases

Literature Mining for the Discovery of Hidden Connections between Drugs, Genes and Diseases

Effects of parathyroid hormone-related protein and macrophage inflammatory protein-1α in Jurkat T-cells on tumor formationin vivoand expression of apoptosis regulatory genesin vitro

B7-H6 : un nouveau signal d’alarme pour les cellulesnatural killer

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