Corelations Between the Use of Medical Substances and the Incidence Infections Produced by Clostridium Difficile Species

Abstract

Antibiotherapy is the main determinant of Clostridium difficile infection due to the imbalance determined in the intestinal flora. Clostridium difficile infection can be considered a current public health problem, given the increased incidence, both as a nosocomial infection as well as at community level, by excessive, uncontrolled and unjustified use of antibiotics, high contagiousness, negative influence on health systems in the increased number of days of hospitalization and implicitly increased costs, and last but not least, the substantial deterioration of the quality of the patient�s life. The retrospective study over a 12-month period over a group of 106 patients revealed the following profile of the patient affected by Clostridium difficile infection: females, aged 66.75 � 15.66, from the urban area, hospitalized in the medical section, who had diarrhea more than 2 days after admission, but up to 28 days after this event, due to prolonged antibiotic therapy with ceftriaxone, associated with a gastric secretion inhibitor, on a background of multiple associated pathologies. It is very important for all health systems to control this phenomenon and this is only possible by applying effective measures to prevent the onset of CDI, of relapses and contamination, thus identifying the judicious use of antibiotics.

The Characterization of Antibiotic Resistance of Bacterial Isolates from Intensive Care Unit Patient Samples in a University Affiliated Hospital in Romania

“…Hospitals are a critical component of the antimicrobial resistance problem worldwide [2], in the condition in which hospital acquired infections (HAIs) have been shown to occur about 5 to 10 times more in the patients admitted in ICUs, which are critically ill patients [3][4][5][6][7][8]. A significant problem in intensive care units is constantly increasing resistance to these antibiotics, the emergence and spread of antimicrobial resistance (AMR) being now considered a global public health threat [9].…”

Distribution of Pathogens Involved in Infections in Oncological Patients and their Antibiotic Resistance Profile

“…Antimicrobial resistance (AMR) is a serious threat to public health and patient safety in Europe, leading to mounting healthcare costs, patient treatment failure, and deaths. [19,24]. The conditions that affect patient`s immunity, like cancer, lung and gastrointestinal diseases, increase the risk of MDR, contributing to the spread of MDR isolates [25][26][27][28][29].…”

Advantages of Negative Pressure Therapy in Local Diabetic Foot Treatment

“…Before the intervention, after the hydroelectolytic rebalancing, it is obtained the informed consent of the patient ( fig. 1) The general progression is rapidly favorable postoperatively, under insulin therapy, antibiotic therapy (cefoperazone+sulbactam 2g/12 h, metronidazole 1g/12 h in the first 48 h, subsequently replacing cefoperazone with meropenem -500mg/8 g and ciprofloxacin 200mg/ 12 h according to the antibiotic results, with the notice of the responsible with the use of antibiotics policy at the unit level), low molecular weight anticoagulant -fraxiparin 3800 u.i./12 h, gastric antisecretor, antialgic, probiotics (as an adjunct in the prevention of clostridium difficile infection) [9], amino acid complex, protein hydrolysates, endovemous infusions with micromolecular solutions, group B vitamins, non-steroidal anti-inflammatory drugs, with decreased glycemic values (glucose=183 mg/dL), remission of leukocytosis (number of leukocytes= 8.73 x 10 3 /L), remission of nitrogen retension (creatinine= 0.96 mg/dL, urea serum=32 mg/dL). The patient becomes cooperative, successfully passing even the alcohol withdrawal period as a result of specific psychiatric treatment.…”