Corelease of neuropeptide Y like immunoreactivity with catecholamines from the adrenal gland during splanchnic nerve stimulation in anesthetized dogs

Briand, Richard; Yamaguchi, Naoko; Gagné, Jacques; Kimura, Tomohiko; Farley, L; Foucart, Sylvain; Nadeau, Réginald; Champlain, Jacques de

doi:10.1139/y90-050

Cited by 12 publications

(4 citation statements)

References 8 publications

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“…It has been reported that NPY release correlates with catecholamines in the cat (Lundberg et al, 1986). Similar results were seen in the dog: a 40-Hz burst of electrical stimulation caused a 2-fold increase in the release of NPY, which was significantly correlated with both adrenaline and noradrenaline release (Briand et al, 1990). The effect appears to be mediated by acetylcholine acting through the nicotinic receptor, as the nicotinic receptor antagonist, hexamethonium, was found to abolish the effect of splanchnic nerve stimulation (Allen et al, 1984) and in retrograde perfusion experiments stimulation of the nicotinic receptor caused the release of NPY, an effect which was antagonised by hexamethonium (Hexum et al, 1987).…”

Section: Role Of the Splanchnic Nerve In Regulatingsupporting

confidence: 82%

Adrenal neuropeptides: Regulation and interaction with ACTH and other adrenal regulators

Whitworth

Kosti

Renshaw

et al. 2003

Microscopy Res & Technique

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It is now well accepted that both the cortex and medulla of the mammalian adrenal gland receive a rich innervation. Many different transmitter substances have been identified in nerves supplying both cortex and medulla and, as well as catecholamines, a wide range of neuropeptides has been found in the adrenal gland. There have been several studies on the affects of age, sodium intake, stress, ACTH, and splanchnic nerve activity on the regulation of adrenal neuropeptide content. There is evidence that the abundance of each of these peptides is actively regulated. Although there have been many studies addressing the individual actions of various neurotransmitters on steroid secretion, adrenal blood flow, and adrenal growth, few have attempted to determine the nature of any interaction between neurotransmitters and the classical adrenal stimulants. There are, however, some significant interactions, particularly in the regulation of zona glomerulosa function. This review necessarily focuses on vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY), as these are the most abundant transmitter peptides in the adrenal gland and the majority of studies have investigated their regulation and actions. However, substance P, calcitonin gene-related peptide (CGRP), neurotensin, and the enkephalins are included where appropriate. Finally, it has been suggested that certain neurotransmitters, particularly VIP, may interact with classical hormone receptors in the adrenal, notably the ACTH receptor. This review attempts to evaluate our current state of knowledge in each of these areas.

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Section: Role Of the Splanchnic Nerve In Regulatingsupporting

confidence: 82%

Adrenal neuropeptides: Regulation and interaction with ACTH and other adrenal regulators

Whitworth

Kosti

Renshaw

et al. 2003

Microscopy Res & Technique

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“…In support of this hypothesis, Bereiter [24] found adrenal blood flow to be correlated with MAP after partial cervical spinal cord transection in cats, and Jasper et al [ 17] reported that blood flow to the adrenal capsule, cortex and medulla was correlated with MAP after hypo tensive hemorrhage in anesthetized dogs. Other studies, however, found no relationship between total adrenal blood flow and changes in MAP produced by insulin [25], endotoxin shock [26], carotid artery occlusion [27], hypo xia [28], splanchnic stimulation [27,29,30], or both normotensive and hypotensive hemorrhage [31]. Considered as a whole, our data support a correlation between changes in MAP and adrenal blood flow.…”

Section: Adrenal Blood Flow and Ca Secretionsupporting

confidence: 59%

Increases in Adrenolumbar Venous Flow and Epinephrine Secretion Elicited by Preoptic and Hypothalamic Stimulation in the Cat

Stoddard¹,

Bergdall²

1992

Neuroendocrinology

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Seventy-five sites were electrically stimulated within the preoptic and hypothalamic areas of anesthetized cats (n = 16). Adrenolumbar venous blood flow, secretion of epinephrine and norepinephrine, heart rate and mean arterial blood pressure were measured at baseline and following a standard stimulus (0.6 mA for 30 s) at each site. The most frequent adrenal medullary response to central stimulation was an increase in the secretion of both catecholamines (ng/min) > 10% of the baseline mean. Seventeen sites (23%) increased adrenolumbar venous flow > 12% above the mean baseline flow rate. This group of sites also evoked significantly greater increases in the secretion of epinephrine, and in mean arterial blood pressure and heart rate. These data support the hypothesis that secreted catecholamines, especially epinephrine, may act locally to increase blood flow through the adrenal medulla.

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“…The release of adrenal CRF is stimulated by haemorrhage in dogs (81), and by splanchnic nerve stimulation in calves the rat does not appear to be regulated by splanchnic nerve activity (24) and stimulation of the peripheral end of the splanchnic nerve has no significant effect on release of NPY from the adrenals in conscious calves (32). In cats and dogs, however, NPY release is increased by splanchnic nerve stimulation, and the release of NPY is significantly correlated with catecholamine release (46). The adrenal content of NPY is influenced by age, nutritional status (47), and 'stress' as insulin-induced hypoglycaemia causes rapid turnover of adrenal NPY (48).…”

Section: The Innervation Of the Adrenal Cortexmentioning

confidence: 99%

The Neuroendocrinology of the Adrenal Cortex

Vinson

Hinson

Tóth

1994

J Neuroendocrinology

108

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Although until relatively recently assumed to be devoid of innervation, there is now ample proof that the adrenal cortex receives specific neurones of several types. A general interpretation of their roles in the regulation of adrenocortical function has not been forthcoming, probably because of the variety of the different experimental approaches which have been used, and the heterogeneous observations which have been made. We here summarize the evidence which is available, and offer the view that neural inputs may provide fine tuning of the responses to systemic factors such as ACTH, through direct actions on specific adrenocortical cells. However, neural regulation also provides an integrative function, through actions on the flow of blood through the gland, which itself exerts a powerful influence on adrenocortical function.

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Corelease of neuropeptide Y like immunoreactivity with catecholamines from the adrenal gland during splanchnic nerve stimulation in anesthetized dogs

Cited by 12 publications

References 8 publications

Adrenal neuropeptides: Regulation and interaction with ACTH and other adrenal regulators

Adrenal neuropeptides: Regulation and interaction with ACTH and other adrenal regulators

Increases in Adrenolumbar Venous Flow and Epinephrine Secretion Elicited by Preoptic and Hypothalamic Stimulation in the Cat

The Neuroendocrinology of the Adrenal Cortex

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