Abstract:Coriander is one of the most ancient culinary herbs known to mankind. It is a member of the Apiaceae family and grows wild in southeastern Europe, India and China. The entire coriander plant, including the leaves, stems, seeds and roots, is used in producing a popular spice with a pleasing lemony flavor. The dried seeds of coriander contain many phenolic compounds, mainly flavonoids, coumarins and phenol carboxylic acids, which are thought to contribute to its medicinal properties. Coriander preparations are t… Show more
“…Coriander seeds contain phytochemicals such as geranyl acetate, linalool, and camphor. The anticancer potential is believed to be due to quercitin and linalool found in coriander [100,174,[185][186][187][188].…”
Gastric cancer (GC) ranks third in terms of cancer-related deaths and is the fifth most commonly diagnosed type of cancer. Its risk factors include Helicobacter pylori infection, Epstein–Barr virus infection, the consumption of broiled and charbroiled animal meats, salt-preserved and smoke-enhanced foods, alcohol drinking, tobacco smoking, exposure to ionizing radiation, and positive family history. The limited effectiveness of conventional therapies and the widespread risk factors of GC encourage the search for new methods of treatment and prevention. In the quest for cheap and commonly available medications, numerous studies focus on herbal medicine, traditional brews, and spices. In this review, we outline the potential use of spices, including turmeric, ginger, garlic, black cumin, chili pepper, saffron, black pepper, rosemary, galangal, coriander, wasabi, cinnamon, oregano, cardamom, fenugreek, caraway, clove, dill, thyme, Piper sarmentosum, basil, as well as the compounds they contain, in the prevention and treatment of GC. We present the potential molecular mechanisms responsible for the effectivity of a given seasoning substance and their impact on GC cells. We discuss their potential effects on proliferation, apoptosis, and migration. For most of the spices discussed, we also outline the unavailability and side effects of their use.
“…Coriander seeds contain phytochemicals such as geranyl acetate, linalool, and camphor. The anticancer potential is believed to be due to quercitin and linalool found in coriander [100,174,[185][186][187][188].…”
Gastric cancer (GC) ranks third in terms of cancer-related deaths and is the fifth most commonly diagnosed type of cancer. Its risk factors include Helicobacter pylori infection, Epstein–Barr virus infection, the consumption of broiled and charbroiled animal meats, salt-preserved and smoke-enhanced foods, alcohol drinking, tobacco smoking, exposure to ionizing radiation, and positive family history. The limited effectiveness of conventional therapies and the widespread risk factors of GC encourage the search for new methods of treatment and prevention. In the quest for cheap and commonly available medications, numerous studies focus on herbal medicine, traditional brews, and spices. In this review, we outline the potential use of spices, including turmeric, ginger, garlic, black cumin, chili pepper, saffron, black pepper, rosemary, galangal, coriander, wasabi, cinnamon, oregano, cardamom, fenugreek, caraway, clove, dill, thyme, Piper sarmentosum, basil, as well as the compounds they contain, in the prevention and treatment of GC. We present the potential molecular mechanisms responsible for the effectivity of a given seasoning substance and their impact on GC cells. We discuss their potential effects on proliferation, apoptosis, and migration. For most of the spices discussed, we also outline the unavailability and side effects of their use.
“…The research has demonstrated the CS hypoglycemic, hypolipidemic, anti-hypertensive, anti-microbial, anti-helminthic, and anti-mutagenic properties. Additionally, it has been demonstrated to alleviate RA symptoms and joint pain [36].…”
Section: Review Of Therapeutic Activitiesmentioning
Rheumatoid Arthritis (RA) is an immune-mediated inflammatory condition. It occurs when the immune system attacks the tissue surrounding joints due to the release of specific chemicals and enzymes that start consuming away the cartilage and bones. The ant-arthritis of Coriandrum sativum (CS) has not been summarized before, so this review aims to assess further and explore its efficacy in RA disorders. The online literature search was performed using databases such as ScienceDirect, PubMed, Google Scholar, Wiley Online, Library, Springer, and Taylor& Francis for review. Articles published from January 2010 to January 2024 were composed. Additionally, the molecular docking of the eight selected CS phytochemicals was carried out against the AR protein target (PDB ID: 2AXJ) to support the review. Different parameters such as docking score, oral bioavailability, drug-likeness, absorption, distribution, metabolism, excretion, and toxicity (ADMET) were examined. Docking scores depicted that, anethole, beta-pinene, camphor, and geraniol phytochemicals demonstrated a commendable potential as inhibitors of 2AXJ molecule. The score hierarchy is camphor (-6.9 kcal/mol), beta-pinene (-5.9 kcal/mol), geraniol (-5.3 kcal/mol), and anethole (-5.2 kcal/mol). The four phytochemicals also appear to have good drug-likeness properties and oral bioavailability. Therefore the in vitro and in vivo studies have demonstrated that CS has strong potential as anti-arthritics and anti-inflammatory. However, clinical trials for both fresh and extracted CS are also necessary to validate the findings.
“…Therefore, petroselinic acid rich oils may offer a low-fat alternative for conventional vegetable oils. It was also suggested that petroselinic acid inhibits the synthesis of arachidonic acid, which could counteract the vasoconstrictive effects related to arachidonic acid overproduction (Shukla and Gupta 2009 ; Weber et al 1995 ). Scheme 1 Petroselinic acid …”
Petroselinic acid, a positional isomer of oleic acid, was isolated from the vegetable oil of Coriandrum sativum fruits. This uncommon fatty acid was subsequently used as substrate for sophorolipid fermentation with a Starmerella bombicola lactone esterase overexpression (oe sble) strain. A petroselinic acid based diacetylated sophorolipid lactone was obtained in high purity without incorporation of de novo synthesized fatty acids such as oleic acid. A total production of 40 g/L was obtained. The petroselinic acid based sophorolipid lactone was subsequently hydrolyzed towards the petroselinic acid based sophorolipid acid. For both compounds, their critical micelle concentration (CMC) and corresponding surface tension were compared to their oleic acid based counterparts. Both petroselinic acid based sophorolipids displayed a much lower CMC value than their oleic acid based counterparts, although their minimal surface tension was the same. Besides, the sophorolipid fermentation product was chemically modified towards a novel C12 sophorolipid aldehyde. This derivative constitutes an interesting building block for further modification towards new-to-nature sophorolipids with high potential for self-assembly applications.Electronic supplementary materialThe online version of this article (doi:10.1186/s13568-016-0199-7) contains supplementary material, which is available to authorized users.
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