Corilagin induces apoptosis, autophagy and ROS generation in gastric cancer cells in�vitro

Xu, Jiajia; Zhang, Gongye; Tong, Yinping; Yuan, Jiahui; Li, Yuanyue; Song, Gang

doi:10.3892/ijmm.2018.4031

Cited by 32 publications

(35 citation statements)

References 48 publications

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“…It was confirmed that compound 18 could induce autophagy, apoptosis and ROS accumulation in gastric cancer cells in vitro [173]. IC50 values of HepG2, Molt-3, HL-60, NPC-BM1, HT 1080 and K562 were 1.42, 0.35, 0.12, 0.81, 1.02, 1.53 mg/mL in vivo , respectively [174].…”

Section: Biological Activitymentioning

confidence: 96%

A Comprehensive Review of the Structure Elucidation of Tannins from Terminalia Linn.

Zhang

Liang

Zhou

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Objectives Tannins with complex structures are important plant resources, which are abundant in the genus Terminalia. Various Terminalia species have been playing an important role in traditional medicine system. A systematic scoping review of Terminalia Linn. research literature for tannins was conducted to summarize the structures of tannins and analysis fragmentation pathway characteristics, which could provide references for the structural analysis of tannins from Terminalia Linn. Methods After an update of the literature search up to September 2018, the terms of Terminalia in all publications were analyzed. Electronic searches were conducted in scifinder and PubMed, and the information from 197 articles in all with regard to the tannin structure study was extracted. Results The compounds of 82 tannins from the genus Terminalia were reviewed. According to the structural differences, they can be divided into three categories, hydrolysable tannins, condensed tannins, and complex tannins, respectively. The fragmentation pathways of 46 identified tannins were analyzed, and the fragmentation rules of tannins were speculated according to different types. Conclusion This review has attracted attention to the active substances in this species such as the tannins summarized in further study. How to improve the extraction and purification technology of tannins from genus Terminalia is an urgent problem to be solved.

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Section: Biological Activitymentioning

confidence: 96%

A Comprehensive Review of the Structure Elucidation of Tannins from Terminalia Linn.

Zhang

Liang

Zhou

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…The majority of patients relapse following surgery [113]. Xu and coworkers [114] studied the efficacy of corilagin on human gastric cancer cell lines (SGC7901 and BGC823) and suggested that it significantly inhibited cell proliferation, apoptosis, and autophagy. It was observed that corilagin fragmented poly (ADP ribose) polymerase (PARP, an indicator of caspase activation) and decreased the level of procaspase-8, procaspase-9, and procaspase-3 in BGC823 and SGC7901cells in a dose-dependent way, as detected by Annexin V/PI staining.…”

Section: Anticancer Activity Of Corilaginmentioning

confidence: 99%

“…Moreover, corilagin has been confirmed to exert a less toxic effect on normal human gastric mucosal epithelial cells (GES-1). Hence, corilagin could be a propitious agent for the cure and management of human gastric cancer [114].…”

Section: Anticancer Activity Of Corilaginmentioning

confidence: 99%

Corilagin in Cancer: A Critical Evaluation of Anticancer Activities and Molecular Mechanisms

et al. 2019

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Corilagin (β-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose), an ellagitannin, is one of the major bioactive compounds present in various plants. Ellagitannins belong to the hydrolyzable tannins, a group of polyphenols. Corilagin shows broad-spectrum biological, and therapeutic activities, such as antioxidant, anti-inflammatory, hepatoprotective, and antitumor actions. Natural compounds possessing antitumor activities have attracted significant attention for treatment of cancer. Corilagin has shown inhibitory activity against the growth of numerous cancer cells by prompting cell cycle arrest at the G2/M phase and augmented apoptosis. Corilagin-induced apoptosis and autophagic cell death depends on production of intracellular reactive oxygen species in breast cancer cell line. It blocks the activation of both the canonical Smad and non-canonical extracellular-signal-regulated kinase/Akt (protein kinase B) pathways. The potential apoptotic action of corilagin is mediated by altered expression of procaspase-3, procaspase-8, procaspase-9, poly (ADP ribose) polymerase, and Bcl-2 Bax. In nude mice, corilagin suppressed cholangiocarcinoma growth and downregulated the expression of Notch1 and mammalian target of rapamycin. The aim of this review is to summarize the anticancer efficacy of corilagin with an emphasis on the molecular mechanisms involving various signaling pathways in tumor cells.

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“…Similarly, Xu et al reported that corilagin [β-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-D-glucose] induced the inhibition of gastric cancer cell (SGC-7901 and BGC-823) growth by activating apoptosis. Moreover, corilagin (10-30 µM) triggered autophagy, which had a cytoprotective effect [245].…”

Section: Phenolic Acidsmentioning

confidence: 99%

Polyphenol-Mediated Autophagy in Cancer: Evidence of In Vitro and In Vivo Studies

Benvenuto

Albonici

Focaccetti

et al. 2020

IJMS

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One of the hallmarks of cellular transformation is the altered mechanism of cell death. There are three main types of cell death, characterized by different morphological and biochemical features, namely apoptosis (type I), autophagic cell death (type II) and necrosis (type III). Autophagy, or self-eating, is a tightly regulated process involved in stress responses, and it is a lysosomal degradation process. The role of autophagy in cancer is controversial and has been associated with both the induction and the inhibition of tumor growth. Autophagy can exert tumor suppression through the degradation of oncogenic proteins, suppression of inflammation, chronic tissue damage and ultimately by preventing mutations and genetic instability. On the other hand, tumor cells activate autophagy for survival in cellular stress conditions. Thus, autophagy modulation could represent a promising therapeutic strategy for cancer. Several studies have shown that polyphenols, natural compounds found in foods and beverages of plant origin, can efficiently modulate autophagy in several types of cancer. In this review, we summarize the current knowledge on the effects of polyphenols on autophagy, highlighting the conceptual benefits or drawbacks and subtle cell-specific effects of polyphenols for envisioning future therapies employing polyphenols as chemoadjuvants.

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Corilagin induces apoptosis, autophagy and ROS generation in gastric cancer cells in�vitro

Cited by 32 publications

References 48 publications

A Comprehensive Review of the Structure Elucidation of Tannins from Terminalia Linn.

A Comprehensive Review of the Structure Elucidation of Tannins from Terminalia Linn.

Corilagin in Cancer: A Critical Evaluation of Anticancer Activities and Molecular Mechanisms

Polyphenol-Mediated Autophagy in Cancer: Evidence of In Vitro and In Vivo Studies

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