Corin plays a protective role via upregulating MAPK and downregulating eNOS in diabetic nephropathy endothelial dysfunction

Xue, Meiting; Shi, Yue; Pang, Aiming; Men, Li; Hu, Yahui; Zhou, Pengfei; Long, Guangfeng; Tian, Xin; Wang, Rong; Zhao, Yonghua; Liao, Xudong; Shen, Yanna; Cui, Yujie

doi:10.1096/fj.201900531rr

Cited by 11 publications

(8 citation statements)

References 35 publications

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“…Synthesized as a zymogen, corin needs to be cleaved by a proprotein convertase subtilisin/kexin-6 (PCSK6, also called PACE4) in order to be activated ( Chen et al, 2018 ). The kidney is the second organ with the highest amount of corin after the heart ( Xue et al, 2020 ). Corin expression has been detected in the proximal tubule, the distal tubule (largely in the thick ascending medullary loop), and the collecting duct (especially in the internal medullary collector duct; Theilig and Wu, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Protective Renal Effects of Atrial Natriuretic Peptide: Where Are We Now?

Choi

Fernández

2021

Front. Physiol.

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Atrial natriuretic peptide belongs to the family of natriuretic peptides, a system with natriuretic, diuretic, and vasodilator effects that opposes to renin-angiotensin system. In addition to its classic actions, atrial natriuretic peptide exerts a nephroprotective effect given its antioxidant and anti-inflammatory properties, turning it as a beneficial agent against acute and chronic kidney diseases. This minireview describes the most relevant aspects of atrial natriuretic peptide in the kidney, including its renal synthesis, physiological actions through specific receptors, the importance of its metabolism, and its potential use in different pathological scenarios.

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Section: Introductionmentioning

confidence: 99%

Protective Renal Effects of Atrial Natriuretic Peptide: Where Are We Now?

Choi

Fernández

2021

Front. Physiol.

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“…3A ) revealed that the expression of APJ in the renal tissues of rats was decreased after the apelin-13 injection at 8 weeks compared with that at 3 weeks. NO production could relieve the diabetic nephropathy-induced vascular damage in the renal tissue ( 21 ). Therefore, the production of NO, Ang II and ET-1 was detected in the renal tissues.…”

Section: Resultsmentioning

confidence: 99%

Apelin‑13 alleviates diabetic nephropathy by enhancing nitric oxide production and suppressing kidney tissue fibrosis

et al. 2021

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Diabetes is a serious metabolic disease, and the kidney damage induced by diabetes also seriously affects the survival of patients. Apelin is a molecule that plays a crucial role in lipid metabolism, and recent studies have revealed that apelin-13, a subtype of apelin, plays an important role in regulating blood glucose levels. However, the role of apelin-13 in diabetic nephropathy remains unclear. In the present study, a rat model of diabetic nephropathy was constructed by the injection of streptozocin (STZ). During this process, these rats were injected with apelin-13. The blood glucose, urine protein and insulin levels were determined weekly. Next, the expression of angiotensin domain type 1 receptor-associated protein (APJ), endothelial nitric oxide synthase (eNOS), E-cadherin and α-smooth muscle actin (α-SMA) in the kidney tissues was determined with western blotting. Then, the endothelial cells of glomerular vessels were cultured with high glucose medium. These cells were treated with apelin-13 for 24 h. Finally, cell viability of these cells and the expression of APJ, eNOS, E-cadherin and α-SMA in these cells were determined with western blotting. As a result, treatment of apelin-13 induced the lower levels of blood glucose and urine protein.In addition, application of apelin-13 promoted the production of insulin and alleviated the insulin resistance. Treatment with apelin-13 promoted the expression of APJ, eNOS and E-cadherin while it suppressed the expression of α-SMA in kidney tissues of rats and endothelial cells of glomerular vessels. Furthermore, application of apelin-13 also promoted the cell viability of these cells. In conclusion, apelin-13 relieved diabetic nephropathy by promoting the production of nitric oxide (NO) and alleviating the fibrosis of kidney tissues.

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“…Diabetes mellitus usually causes microangiopathy, which in turn leads to chronic progressive lesions, hypofunction and failure of tissues and organs such as eyes, kidneys, nerves, heart and blood vessels. It has been shown that the IL-33/ST2 signaling pathway is activated in diabetic nephropathy ( Elsherbiny et al, 2020 ), and endothelial dysfunction can be induced during the development of diabetic nephropathy ( Xue et al, 2020 ). Interestingly, ST2, the key protein in this study, can be produced by endothelial cells, which activate immune responses and trigger organismal protective mechanisms by expressing large amounts of ST2 during the sepsis process ( Huang et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

IL-33 and Soluble ST2 Are Associated With Recurrent Spontaneous Abortion in Early Pregnancy

Zhao

Fu²,

Ding³

et al. 2022

Front. Physiol.

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Normal pregnancy is related to the successful transition from type 1 cellular immunity to type 2 cellular immunity. Therefore, this study aimed to investigate whether there is abnormal expression of cytokines in the process of inducing Recurrent spontaneous abortion (RSA). Interleukin (IL)-33 is a new member of the IL-1 family, and ST2, as IL-33’s receptor, induced the production of type 2 cytokines. In this study, blood samples were collected from 19 non-pregnant women of normal childbearing age, 28 normal pregnant women, and 33 women with RSA. The serum concentrations of IL-33 and ST2 were detected by flow cytometry. Our results showed that the serum concentrations of IL-33 and ST2 in the RSA group were significantly higher than those in the healthy control group (IL-33: P < 0.05; ST2: P < 0.0001), and IL-33 and ST2 had a higher level in the process of RSA predictive value. In addition, this study initially found that the serum concentrations of IL-33 and ST2 were not significantly correlated with the number of weeks of pregnancy, and there was a lower correlation between IL-33 and ST2 during RSA. This result may be related to the small number of cases. This study is the first time to correlate the changes in serum concentrations of IL-33 and ST2 with RSA, which may be a novel biomarker for the prediction and treatment of RSA.

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Corin plays a protective role via upregulating MAPK and downregulating eNOS in diabetic nephropathy endothelial dysfunction

Cited by 11 publications

References 35 publications

Protective Renal Effects of Atrial Natriuretic Peptide: Where Are We Now?

Protective Renal Effects of Atrial Natriuretic Peptide: Where Are We Now?

Apelin‑13 alleviates diabetic nephropathy by enhancing nitric oxide production and suppressing kidney tissue fibrosis

IL-33 and Soluble ST2 Are Associated With Recurrent Spontaneous Abortion in Early Pregnancy

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