Cornea Society Nomenclature for Ocular Surface Rehabilitative Procedures

Daya, Sheraz M.; Chan, Clara C.; Holland, Edward J.

doi:10.1097/ico.0b013e318207f135

Cited by 44 publications

(24 citation statements)

References 54 publications

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“…The work of the Corneal Society in standardizing the nomenclature for ocular surface reconstructive techniques is to be welcomed [9]. The data presented in this manuscript highlight how a set of standardized outcome measures can be used to document outcomes.…”

Section: Resultsmentioning

confidence: 99%

Three-Year Outcomes of Cultured Limbal Epithelial Allografts in Aniridia and Stevens-Johnson Syndrome Evaluated Using the Clinical Outcome Assessment in Surgical Trials Assessment Tool

Shortt

Bunce

Levis

et al. 2014

Stem Cells Translational Medicine

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Limbal stem cell deficiency (LSCD) is an eye disorder in which the stem cells responsible for forming the surface skin of the cornea are destroyed by disease. This results in pain, loss of vision, and a cosmetically unpleasant appearance. Many new treatments, including stem cell therapies, are emerging for the treatment of this condition, but assessment of these new technologies is severely hampered by the lack of biomarkers for this disease or validated tools for assessing its severity. The aims of this study were to design and test the reliability of a tool for grading LSCD, to define a set of core outcome measures for use in evaluating treatments for this condition, and to demonstrate their utility. This was achieved by using our defined outcome set (which included the Clinical Outcome Assessment in Surgical Trials of Limbal stem cell deficiency [COASTL] tool) to evaluate the 3-year outcomes for allogeneic ex vivo cultivated limbal epithelial transplantation (allo-CLET) in patients who had bilateral total LSCD secondary to aniridia or Stevens-Johnson syndrome. The results demonstrate that our new grading tool for LSCD, the COASTL tool, is reliable and repeatable, and that improvements in the biomarkers used in this tool correlate positively with improvements in visual acuity. The COASTL tool showed that following allo-CLET there was a decrease in LSCD severity and an increase in visual acuity up to 12 months post-treatment, but thereafter LSCD severity and visual acuity progressively deteriorated.

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Section: Resultsmentioning

confidence: 99%

Three-Year Outcomes of Cultured Limbal Epithelial Allografts in Aniridia and Stevens-Johnson Syndrome Evaluated Using the Clinical Outcome Assessment in Surgical Trials Assessment Tool

Shortt

Bunce

Levis

et al. 2014

Stem Cells Translational Medicine

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“…Early approaches to treating unilateral LSCD were based on direct transplantation of donor limbal tissue from the fellow eye to the affected eye 3 4. Conjunctival limbal autografting (CLAU) typically involved taking two pieces of limbal tissue from the donor eye, each extending up to 3 clock hours.…”

Section: Introductionmentioning

confidence: 99%

Autologous simple limbal epithelial transplantation for unilateral limbal stem cell deficiency: multicentre results

et al. 2016

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“…[1][2][3] To improve the outcomes in patients with total LSCD, several investigators have proposed the transplantation of cultivated corneal epithelium via ex vivo expansion of limbal epithelial stem cells. [4][5][6][7][8][9][10][11] The procedure can be performed with autologous or allogeneic donor tissue, but in the latter case, it necessarily requires the use of systemic immunosuppressants, with increased risks of systemic complications, including infection and liver and renal dysfunction.…”

mentioning

confidence: 99%

Transplantation of Conjunctival Epithelial Cells Cultivated Ex Vivo in Patients With Total Limbal Stem Cell Deficiency

Ricardo

Cristovam²,

Filho³

et al. 2013

Cornea

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Cornea Society Nomenclature for Ocular Surface Rehabilitative Procedures

Abstract: Agreed nomenclature for transplantation procedures used in ocular surface rehabilitation has been developed, and use of this common terminology should help communication among those involved in this field.

Cited by 44 publications

References 54 publications

Three-Year Outcomes of Cultured Limbal Epithelial Allografts in Aniridia and Stevens-Johnson Syndrome Evaluated Using the Clinical Outcome Assessment in Surgical Trials Assessment Tool

Three-Year Outcomes of Cultured Limbal Epithelial Allografts in Aniridia and Stevens-Johnson Syndrome Evaluated Using the Clinical Outcome Assessment in Surgical Trials Assessment Tool

Autologous simple limbal epithelial transplantation for unilateral limbal stem cell deficiency: multicentre results

Transplantation of Conjunctival Epithelial Cells Cultivated Ex Vivo in Patients With Total Limbal Stem Cell Deficiency

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