Cornea Thermography: Optimal Evaluation of the Outcome and the Resulting Reproducibility

Konieczka, Katarzyna; Schoetzau, Andreas; Koch, Simone; Hauenstein, Daniela

doi:10.1167/tvst.7.3.14

Cited by 16 publications

(15 citation statements)

References 33 publications

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“…The basic methods for data recording and processing have already been described in another recent publication 26. The most important aspects are repeated here.…”

Section: Methodsmentioning

confidence: 99%

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Effects of the Glaucoma Drugs Latanoprost and Brimonidine on Corneal Temperature

Konieczka

Koch

Hauenstein

et al. 2019

Trans. Vis. Sci. Tech.

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Purpose The aim of this study was to investigate the effects of the glaucoma drugs latanoprost, brimonidine, and the combination of both on the central corneal temperature (CT) of healthy subjects by means of infrared thermography. Changes of the central CT may reflect changes of ocular blood flow. Methods Before application and during 2 hours after the application of latanoprost, brimonidine, or the combination of both in one eye, the CT in both eyes of 40 healthy subjects was measured repeatedly. Results Brimonidine reduced CT by approximately 0.5°C. This effect was statistically significant ( P < 0.0001). Latanoprost, however, had a very small and insignificant influence ( P = 0.47). Accordingly, the combination of brimonidine and latanoprost also reduced CT up to 0.5°C, and this effect was statistically significant ( P < 0.0001). Conclusions Brimonidine, but not latanoprost, had a significant effect on central CT. This cooling effect of brimonidine is most probably due to a drug-induced reduction of blood circulation in the ciliary body and iris and to a certain extent also to a reduction of blood flow in the fundus of the eye. Translational Relevance This study shows evidence that thermography of the cornea provides indirect information on the influence of drugs on the blood flow to the anterior segment of the patient's eye.

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“…The basic methods for data recording and processing have already been described in another recent publication 26. The most important aspects are repeated here.…”

Section: Methodsmentioning

confidence: 99%

“…The basic methods for evaluating and processing row data have already been described in another recent publication 26. To simplify calculations, the median of the CTm values across the 28 test locations was calculated for each subject and timepoint (CTM).…”

Section: Methodsmentioning

confidence: 99%

Effects of the Glaucoma Drugs Latanoprost and Brimonidine on Corneal Temperature

Konieczka

Koch

Hauenstein

et al. 2019

Trans. Vis. Sci. Tech.

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“…Technically speaking, the higher the temperature of the surface, the higher the power per radiating area. For the human body, this radiation is several hundred Watts in the infrared range [ 116 ]. Initially, thermography was invented to measure changes in skin temperature.…”

Section: Imaging Modalitiesmentioning

confidence: 99%

Novel Approaches for Imaging-Based Diagnosis of Ocular Surface Disease

et al. 2020

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Imaging has become indispensable in the diagnosis and management of diseases in the posterior part of the eye. In recent years, imaging techniques for the anterior segment are also gaining importance and are nowadays routinely used in clinical practice. Ocular surface disease is often synonymous with dry eye disease, but also refers to other conditions of the ocular surface, such as Meibomian gland dysfunction or keratitis and conjunctivitis with different underlying causes, i.e., allergies or infections. Therefore, correct differential diagnosis and treatment of ocular surface diseases is crucial, for which imaging can be a helpful tool. A variety of imaging techniques have been introduced to study the ocular surface, such as anterior segment optical coherence tomography, in vivo confocal microscopy, or non-contact meibography. The present review provides an overview on how these techniques can be used in the diagnosis and management of ocular surface disease and compares them to clinical standard methods such as slit lamp examination or staining of the cornea or conjunctiva. Although being more cost-intensive in the short term, in the long term, the use of ocular imaging can lead to more individualized diagnoses and treatment decisions, which in turn are beneficial for affected patients as well as for the healthcare system. In addition, imaging is more objective and provides good documentation, leading to an improvement in patient follow-up and education.

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“…Since Mapstone [4][5][6] introduced infrared thermography of the ocular surface, the method has become widely used. In ophthalmology, ocular surface temperature (OST) has been investigated in ocular inflammation [7], tear film abnormalities [8], analysis of bleb function after glaucoma surgery [9] and after corneal refractive surgery [10] and cataract surgery [11], and in the evaluation of ocular blood flow [12].…”

Section: Introductionmentioning

confidence: 99%

“…As the cornea is an avascular tissue, the central corneal temperature is mainly influenced by tear film evaporation and heat convection and conduction of the aqueous humour [18]. Nevertheless, the temperature of the peripheral cornea may also be influenced by blood flow in the perilimbal vessels [12].…”

Section: Introductionmentioning

confidence: 99%

Ocular Surface Disease Index and Ocular Thermography in Keratoconus Patients

Németh

Langenbucher

Eppig

et al. 2020

Journal of Ophthalmology

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Purpose. Keratoconus (KC) has been defined as a “noninflammatory” corneal disease, but recent studies have noted a potential inflammatory origin. We analysed the Ocular Surface Disease Index (OSDI) and ocular surface temperature (OST) in KC patients compared to controls. Patients and Methods. A total of 179 eyes in 90 patients with KC (topographic keratoconus classification 0-1 to 4, age 36.1 ± 12.5 years, 65.9% males) and 82 eyes in 41 controls (age 36.4 ± 12.8 years, 47.6% males) were examined. The participants completed the OSDI questionnaire and underwent corneal topography, tomography, and thermography. Additional outcome measures were vision- and discomfort-related OSDI subscores and mean OST at the corneal centre during 10 seconds of sustained eye opening after blinking. Results. The OSDI score (31.4 ± 22.4 vs. 17.5 ± 17.9) and vision- (17.7 ± 14.6 vs. 10.5 ± 13.2) and discomfort-related (14.3 ± 10.7 vs. 9.4 ± 10.5) OSDI subscores were significantly higher in KC patients than in controls (p<0.001). We found no significant difference in the central corneal OST (34.2 ± 0.6°C vs. 34.2 ± 0.7°C; p=0.41) between the two groups (p≥0.22). The OSDI score and subscores poorly to fairly correlated with the surface asymmetry index (SAI) and surface regularity index (SRI; r > 0.174, p<0.005), but did not correlate with the central corneal OST (r < 0.001). OST also did not correlate with the SAI, SRI, and central corneal thickness (r ≥ −0.086). Conclusion. KC patients had increased OSDI scores and vision- and discomfort-related OSDI subscores without an increase in the OST compared to a normal population. OSDI score/subscores weakly correlate with SAI and SRI but do not correlate with OST in KC patients or controls. Vision- and discomfort-related symptoms of KC have to be managed in parallel in ophthalmological practice, but the necessity of anti-inflammatory treatment cannot be verified through ocular thermography.

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Cornea Thermography: Optimal Evaluation of the Outcome and the Resulting Reproducibility

Cited by 16 publications

References 33 publications

Effects of the Glaucoma Drugs Latanoprost and Brimonidine on Corneal Temperature

Effects of the Glaucoma Drugs Latanoprost and Brimonidine on Corneal Temperature

Novel Approaches for Imaging-Based Diagnosis of Ocular Surface Disease

Ocular Surface Disease Index and Ocular Thermography in Keratoconus Patients

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