Corneal and Anterior Chamber Morphology in Human Immunodeficiency Virus-1–Infected Patients Without Opportunistic Infections

Çetin, Ebru; Kutlu, Selda Sayın; Parca, Osman; Kutlu, Murat; Pekel, Gökhan

doi:10.1097/icl.0000000000000468

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“…Cetin and colleagues (2018) undertook a comprehensive study of corneal and anterior chamber morphology but found no significant differences in a range of anterior ocular structural measures (e.g. corneal endothelial cell density, corneal thickness and volume, anterior chamber depth and volume) between HIV-positive individuals and healthy controls [25], despite a previous study demonstrating increased risk of corneal endothelial cell polymegathism in HIV-infected individuals [26].…”

Section: Discussionmentioning

confidence: 99%

Meibomian gland dropout is associated with immunodeficiency at HIV diagnosis: Implications for dry eye disease

et al. 2020

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Aim: To characterize anterior eye health and tear film characteristics in individuals with human immunodeficiency virus (HIV) undergoing anti-retroviral therapy. Methods:This cross-sectional study involved 35 adults, categorized as healthy controls (n=18) or as HIV-positive patients (n=17), with no history of opportunistic infection or current ocular fundus abnormalities. Participants underwent a comprehensive anterior eye assessment. Primary outcome measures were dry eye symptoms (Ocular Surface Disease Index survey), tear film osmolarity, and extent of meibomian gland dropout. Secondary outcomes measures were ocular redness, tear film stability, and ocular surface staining.Levels of 36 cytokines were assayed from basal tears using a multiplex bead array. Results:The HIV-positive group showed more extensive meibomian gland dropout relative to controls (mean ± SD, controls: 29.6 ± 5.8 versus 37.0 ± 13.9%, p=0.045). The extent of meibomian gland dropout was negatively correlated with blood CD4 T-cell count (a marker of immunodeficiency) at diagnosis (r= -0.69, p=0.006). All other tests of anterior ocular health, including dry eye symptom levels, were not significantly different between the groups. There were no significant inter-group differences for the 36 cytokines assayed in the tear film. Conclusions:We find greater meibomian gland dropout in HIV-positive individuals that is related to disease severity at diagnosis. Given this feature predisposes to dry eye disease, it suggests the need for long-term studies of anterior eye health in people with HIV.

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Section: Discussionmentioning

confidence: 99%

Meibomian gland dropout is associated with immunodeficiency at HIV diagnosis: Implications for dry eye disease

et al. 2020

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show abstract

Corneal and Anterior Chamber Morphology in Human Immunodeficiency Virus-1–Infected Patients Without Opportunistic Infections

Abstract: Corneal density, CECD, ACV, and ACD showed significant correlation with age in HIV-1-infected patients. Further studies are needed to show whether ocular parameters may serve as useful tools to monitor HIV-related accelerated aging.

Cited by 1 publication

References 25 publications

Meibomian gland dropout is associated with immunodeficiency at HIV diagnosis: Implications for dry eye disease

Meibomian gland dropout is associated with immunodeficiency at HIV diagnosis: Implications for dry eye disease

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