Corneal and Conjunctival Epithelial Staining in Hydrogel Contact Lens Wearers

Brautaset, Rune; Nilsson, Maria; Leach, Norman E.; Miller, William L.; Gire, Anisa; Quintero, Sam; Bergmanson, Jan P.G.

doi:10.1097/icl.0b013e3181891439

Cited by 25 publications

(15 citation statements)

References 19 publications

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“…The incidence of adverse events is consistent with previous reports on complications of SCL use. Brautaset et al, 20 studied 330 silicone-hydrogel contact lens wearers and found conjunctival and corneal staining in 32.5% and 19.5% of subjects, respectively. The proportion of patients who developed corneal staining in the present study (15%) is in the lower range of other published reports from studies with modern SCLs.…”

Section: Discussionmentioning

confidence: 99%

Continuous 24-Hour Monitoring of Intraocular Pressure Patterns With a Contact Lens Sensor

Mansouri¹,

Medeiros²,

Tafreshi³

et al. 2012

Arch Ophthalmol

165

136

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Purpose To determine the safety, tolerability, and reproducibility of intraocular pressure (IOP) patterns during repeated continuous 24-hour IOP monitoring with a telemetric contact-lens sensor (CLS). Design Prospective clinical trial. Participants Forty patients with suspect (n=21) or established glaucoma (n=19). Methods Patients participated in two 24-hour IOP monitoring sessions (S1 and S2) at a 1-week interval using the SENSIMED Triggerfish CLS (Sensimed AG, Switzerland). Patients pursued daily activities and sleep behavior was not controlled. The recordings were analyzed for differences between daytime and nighttime data and for reproducibility of signal patterns between the 2 sessions. Pearson correlations were obtained by pairing intervals across sessions. Main Outcome Measures Adverse events (AE), tolerability using the visual analogue score (VAS), and reproducibility of IOP patterns. Results Mean age was 55.5 ± 15.7 years and 60.0% were male. Main AEs were blurred vision (82.5%), conjunctival hyperemia (80.0%), and superficial punctate keratitis (15.0%). Patients reported a mean VAS of 27.2 ± 18.5 (S1) and 23.8 ± 18.7 (S2) (P = 0.216). Positive linear slopes of the sensor signal from the wake to the sleep period were detected for the ‘no glaucoma medication’ group (slope: 0.14 ± 0.15, p < 0.01, S1; slope: 0.12 ± 0.17, p = 0.03, S2) and for the ‘glaucoma medication’ group (slope: 0.03 ± 0.24, p = 0.52, S1; slope: 0.11 ± 0.16, p = 0.02, S2). Overall correlation between the two sessions was 0.59 (0.51 ‘no glaucoma medication’; 0.63 ‘glaucoma medication’) (P = 0.117). Conclusions Repeated use of the CLS demonstrated good safety and tolerability. The recorded IOP patterns showed fair reproducibility, suggesting that data from 24-h continuous IOP monitoring may be useful in the management of glaucoma patients.

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Section: Discussionmentioning

confidence: 99%

Continuous 24-Hour Monitoring of Intraocular Pressure Patterns With a Contact Lens Sensor

Mansouri¹,

Medeiros²,

Tafreshi³

et al. 2012

Arch Ophthalmol

165

136

View full text Add to dashboard Cite

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“…After tear collection at visits 1 and 6, sodium fluorescein dye was instilled to assess corneal surface staining using the Cornea and Contact Lens Research Unit (CCLRU) scale. 35 The total staining score was the sum of all five corneal regions.…”

Section: Methodsmentioning

confidence: 99%

Changes in Tear Cytokine Concentrations Following Discontinuation of Soft Contact Lenses—A Pilot Study

Chao

Golebiowski²,

Stapleton³

et al. 2016

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Purpose This study investigated changes in selected tear cytokine concentrations (IL-1β, IL-1Ra, IL-6, IL-10, IL-12(p70) and TNF-α) following a 1-week washout from soft contact lens wear (CLW), and the repeatability of cytokine measurements using custom Multiplex assays. Methods A total of 10 subjects completed this 6-visit (immediately following contact lens removal, and after 1, 2, 3, 4 and 7 (±1) days without CLW) pilot study. Approximately 20–30μl of pooled basal tears were collected from both eyes at each visit. Two custom Multiplex assays were used by 2 operators to quantify the concentration of tear cytokines. Tear samples from subjects 1–6 were analysed using the first kit by operator 1. Tear samples from subject 7–10 plus additional tear samples from subjects 1–5, which were used to determine between-kit/operator repeatability, were analysed using the second kit by operator 2. Linear mixed models were used to determine changes in tear cytokine concentrations over time. Between-kit/operator and within-kit/operator repeatability was assessed using a Bland and Altman analysis. Results There were no significant changes in tear cytokine concentrations over a 1-week washout of CLW. More than 99% of the tear samples had detectable levels of cytokines using custom Multiplex assays. Within-kit/operator repeatability was good, but between-kit/operator repeatability was poor; likely due to protein degradation, differences in operator experience and operating procedures. Conclusion A washout period may not be necessary when evaluating changes in tear cytokines with new contact lenses or lens care products. A well-trained operator using standardized operating procedures can produce repeatable measurements using custom Multiplex assays.

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“…It is also recorded on the tarsal conjunctiva (21%) and on the caruncle (Norn, 1964). A clinically significant grade of conjunctival fluorescein staining has been reported to occur in about 12% of non-contact lens wearers (Lakkis and Brennan, 1996;du Toit et al, 2001;Brautaset et al, 2008;, while lissamine green staining has been recorded in 51% of normal subjects (Maissa et al, 2011).…”

Section: Fluorescein Sodiummentioning

confidence: 97%