Corneal anesthesia following application of 0.4% oxybuprocaine hydrochloride ophthalmic solution to normal feline eyes

Giudici, Valentina; Baeza, Sophia; Douet, Jean‐Yves; Régnier, A.

doi:10.1111/vop.12179

Cited by 13 publications

(14 citation statements)

References 43 publications

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“…As expected in this form of early‐onset glaucoma, mean corneal diameter was significantly larger in glaucomatous cats relative to normal cats, and in cats with FCG, larger corneal diameters correlated with decreased corneal sensitivity. Mean CTT was slightly lower in glaucomatous eyes relative to normal eyes; however, the difference was not statistically significant, and the values obtained in our study are generally similar to previously published ranges in normal cats . Similar findings were reported in prior studies involving human PCG patients .…”

Section: Discussionsupporting

confidence: 90%

Relationship between corneal sensitivity, corneal thickness, corneal diameter, and intraocular pressure in normal cats and cats with congenital glaucoma

Telle

Chen

Shinsako

et al. 2018

Veterinary Ophthalmology

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Section: Discussionsupporting

confidence: 90%

Relationship between corneal sensitivity, corneal thickness, corneal diameter, and intraocular pressure in normal cats and cats with congenital glaucoma

Telle

Chen

Shinsako

et al. 2018

Veterinary Ophthalmology

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“…In the current study, the observation group required a shorter time for the onset of the anesthetic effect and the disappearance of pain, and a longer time for the recovery of pain sensation (P<0.01). The study by Giudici et al (21) indicated that following the combined application of procaine in epidural anesthesia, the time for the onset of the anesthetic effect and the disappearance of pain after anesthesia were shortened, and the recovery of pain sensation postsurgery was prolonged compared with the patients who were not administrated with procaine, which were consistent with the results of the present study. However, there are certain differences between the specific data of the two studies, which may be attributed to variation in the included subjects, the specific drug dose and the pain evaluation criteria.…”

Section: Time After Surgery -----------------------------------------supporting

confidence: 92%

Efficacy of procaine combined with ketamine and propofol in pediatric epidural anesthesia

et al. 2020

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In the present study, the effect of procaine combined with ketamine and propofol in pediatric epidural anesthesia was analyzed. A total of 74 children scheduled to undergo surgery under epidural anesthesia were included in the study, and were divided into two groups using a random number table. Accordingly, 37 patients received epidural anesthesia using ketamine and propofol (control group), whereas the remaining patients received procaine combined with ketamine and propofol (observation group). The vital signs, sedative effects, anesthetic effects, pain intensity, anesthetic dose and incidence of adverse reactions were compared between the groups. It was revealed that the heart rate and mean arterial pressure at T4 (following epidural administration) in the observation group was significantly lower compared with those of the control group (P<0.05). However, no statistical difference was observed in the proportion of patients with sedation at Ramsay levels 1-6 between the observation and the control group (P>0.05). Compared with the control group, the observation group reported a shorter latent period for the onset of the anesthetic effect and the disappearance of pain, and a longer period for the recovery of pain sensation (P<0.05). The observation group exhibited prominently lower visual analog scale scores at 6, 12, 18 and 24 h post-surgery compared with the control group (P<0.05). Additionally, the observation group received a lower dose of ketamine and propofol compared with the control group (P<0.05). An incidence of adverse reactions of 8.11% was noted in the observation group during the surgery and anesthesia recovery period, which was lower compared with that of the control group (29.73%) (P<0.05). The results of the present study indicated that the combination of procaine with ketamine and propofol in pediatric epidural anesthesia may be more commonly employed, considering its advantages in accelerating the anesthesia process, improving the anesthetic effects and guaranteeing anesthesia safety. However, only a few indicators of the anesthesia efficacy and a small group of patients were included in the present study, and a long-term comprehensive analysis using a larger sample size is required to address this issue.

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“…2,3,20,21 It has been shown that oxybuprocaine and proxymetacaine produced corneal anesthesia in cats, 22,23 were more potent than bupivacaine or lidocaine in spinal anesthesia, 4 and were also more potent than bupivacaine on infiltrative cutaneous analgesia. 5 In the current experiment, oxybuprocaine and proxymetacaine were 30 and 50 times more potent than lidocaine as an infiltrative anesthetic.…”

Section: Discussionmentioning

confidence: 99%

The Addition of Epinephrine to Proxymetacaine or Oxybuprocaine Solution Increases the Depth and Duration of Cutaneous Analgesia in Rats

Chen

Chiu

Kan

et al. 2016

Regional Anesthesia and Pain Medicine

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Corneal anesthesia following application of 0.4% oxybuprocaine hydrochloride ophthalmic solution to normal feline eyes

Abstract: This is the first study that provides objective information on the depth and duration of corneal anesthesia following instillation of oxybuprocaine in healthy feline eyes.

Cited by 13 publications

References 43 publications

Relationship between corneal sensitivity, corneal thickness, corneal diameter, and intraocular pressure in normal cats and cats with congenital glaucoma

Relationship between corneal sensitivity, corneal thickness, corneal diameter, and intraocular pressure in normal cats and cats with congenital glaucoma

Efficacy of procaine combined with ketamine and propofol in pediatric epidural anesthesia

The Addition of Epinephrine to Proxymetacaine or Oxybuprocaine Solution Increases the Depth and Duration of Cutaneous Analgesia in Rats

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