Corneal Biomechanical Properties and Intraocular Pressure in High Myopic Anisometropia

Xu, Suzhong; Xu, Aiqin; Tao, Aizhu; Wang, Jianhua; Fan, Fan; Liu, Fan

doi:10.1097/icl.0b013e3181e4a60a

Cited by 27 publications

(32 citation statements)

References 29 publications

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“…In 2008, Shen et al 16 suggested that some aspects of the biomechanical properties of the cornea may be compromised in patients with high myopia. Recently, Xu et al 17 found similar results in highly ametropic patients. Therefore, the difference in the biomechanical behavior of these corneas might be a reasonable explanation for the wide scatter of asphericity change in these eyes.…”

Section: Discussionsupporting

confidence: 62%

Corneal asphericity and spherical aberration after refractive surgery

Bottós

Leite

Aventura-Isidro

et al. 2011

Journal of Cataract and Refractive Surgery

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Section: Discussionsupporting

confidence: 62%

Corneal asphericity and spherical aberration after refractive surgery

Bottós

Leite

Aventura-Isidro

et al. 2011

Journal of Cataract and Refractive Surgery

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“…Some clinical studies confirmed that changes in corneal curvature and crystalline lens thickness are not associated with development of myopia; thus, their roles in this process are assumed to be insignificant [14,15]. Moreover, Xu et al [16] investigated corneal biomechanical properties and AL in the patients with high myopic anisometropia and found that the differences in CCT were not statistically significant and the difference Fig. 1 The relationship between axial length and peripapillary retinal nerve fiber layer thickness in all patients with myopic anisometropia Int Ophthalmol in AL between the two eyes resulted in anisometropia.…”

Section: Discussionmentioning

confidence: 93%

Effect of myopic anisometropia on anterior and posterior ocular segment parameters

et al. 2016

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The purpose of this study is to investigate the differences in anterior and posterior segment parameters of more myopic eyes compared to fellow eyes using spectral domain optical coherence tomography and optical biometer device in patients with myopic anisometropia. This prospective cross-sectional study included 42 myopic anisometropic patients with and without amblyopia, aged between 7 and 40 years old. The refractive error and keratometry values, axial length (AL), central corneal thickness (CCT), peripapillary retinal nerve fiber layer thickness (RNFLT), and central macular thickness (CMT) were evaluated. Eighteen of the patients had myopic anisometropia with amblyopia, and the remaining 24 had myopic anisometropia without amblyopia. There were 23 female and 19 male patients with a mean age as 23.67 ± 10.12 years (range 7-40). The right eyes of the subjects significantly had a higher degree of myopia. There was a significant difference in mean best-corrected visual acuity (0.195 ± 0.234 vs. 0.011 ± 0.025 logMAR, p < 0.001), spherical equivalent refraction (-3.95 ± 1.38 vs. -1.04 ± 0.99 D, p < 0.001), AL (25.06 ± 1.27 vs. 23.99 ± 0.98 mm, p < 0.001), and RNFLT (89.24 ± 12.84 vs. 94.57 ± 10.81 μm, p < 0.001) between the more myopic and fellow eyes in all patients. On the contrary, there was no significant difference in CMT and anterior segment parameters including mean keratometry and CCT in all patients and either group. During the development of the myopic anisometropia, more myopic eyes have significantly more myopic refraction, longer AL and thinner RNFLT compared to the fellow eyes.

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“…In that case, the ORA may be useful for the diagnosis and management of glaucoma and ocular hypertension (OHT) [25]. Several studies have reported that myopic subjects, especially in the highly myopic group, showed higher IOP than controls [12, 29–32]. Altan et al [15] found that IOPcc measured by ORA, but not IOP, was significantly higher in highly myopic eyes than in nonmyopia or low myopia group.…”

Section: Discussionmentioning

confidence: 99%

“…These inconsistent results could be justified by differences related to other factors such as race, range of age, gender, refractive status, axial length, corneal curvature, and CCT. [14, 19, 20] Although there is a higher prevalence of glaucoma among myopic eyes than that in nonmyopic eyes [29, 32], it is still unclear why myopia increases IOP. Jiang et al [14] attributed these differences of corneal biomechanical properties to the difference of age between groups.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Corneal Biomechanical Properties and Intraocular Pressure in Myopic Spanish Healthy Population

Buey

Lavilla

Ascaso

et al. 2014

Journal of Ophthalmology

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Purpose. To examine biomechanical parameters of the cornea in myopic eyes and their relationship with the degree of myopia in a western healthy population. Methods. Corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann correlated intraocular pressure (IOP), and corneal compensated IOP (IOPcc) were measured using the ocular response analyzer (ORA) in 312 eyes of 177 Spanish subjects aged between 20 and 56 years. Refraction was expressed as spherical equivalent (SE), which ranged from 0 to −16.50 diopters (D) (mean: −3.88 ± 2.90 D). Subjects were divided into four groups according to their refractive status: group 1 or control group: emmetropia (−0.50 ≤ SE < 0.50); group 2: low myopia (−0.75 ≤ SE < 3.00 D); group 3: moderate myopia (−3.00 ≤ SE ≤ −6.00 D); and group 3: high myopia (SE greater than −6.00 D). We analyzed the relationship between corneal biomechanics measured with ORA and SE. Results. CH in the emmetropia, low myopia, moderate myopia, and high myopia groups was 11.13 ± 0.98, 11.49 ± 1.25, 10.52 ± 1.54, and 10.35 ± 1.33 mmHg, respectively. CH in the highly myopic group was significantly lower than that in the emmetropic group (P = 0.07) and low myopic group (P = 0.035); however, there were no differences with the moderate myopic group (P = 0.872). There were no statistically significant differences regarding IOP among the four groups (P > 0.05); nevertheless, IOPcc was significantly higher in the moderately myopic (15.47 ± 2.47 mmHg) and highly myopic (16.14 ± 2.59 mmHg) groups than in the emmetropia (15.15 ± 2.06 mmHg) and low myopia groups (14.53 ± 2.37 mmHg). No correlation between age and the measured parameters was found. CH and IOPcc were weakly but significantly correlated with SE (r = 0.171, P = 0.002 and r = −0.131, P = 0.021, resp.). Conclusions. Present study showed only a very weak, but significant, correlation between CH and refractive error, with CH being lower in both moderately and highly myopic eyes than that in the emmetropic and low myopic eyes. These changes in biomechanical properties of the cornea may have an impact on IOP measurement, increasing the risk of glaucoma.

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Corneal Biomechanical Properties and Intraocular Pressure in High Myopic Anisometropia

Cited by 27 publications

References 29 publications

Corneal asphericity and spherical aberration after refractive surgery

Corneal asphericity and spherical aberration after refractive surgery

Effect of myopic anisometropia on anterior and posterior ocular segment parameters

Assessment of Corneal Biomechanical Properties and Intraocular Pressure in Myopic Spanish Healthy Population

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