Corneal Biomechanical Properties and Retinal Vascular Caliber in Children

Lim, Laurence Shen; Cheung, Ning; Gazzard, Gus; Chan, Yiong‐Huak; Wong, Tien‐Yin; Saw, Seang‐Mei

doi:10.1167/iovs.08-2352

Cited by 17 publications

(10 citation statements)

References 31 publications

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“…However, factors such as age, gender, and CCT have not been adjusted for the results of biomechanical tests in this study. In addition, other factors such as corneal curvature, 16 race, 16 axial length, 17 and retinal vascular caliber 31 may also influence the correlation between myopia and biomechanical properties of the cornea.…”

Section: Discussionmentioning

confidence: 99%

Association between corneal biomechanical properties and myopia in Chinese subjects

Jiang

Shen

Mao

et al. 2011

Eye

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Purpose To examine the relationship between corneal biomechanical properties and the degree of myopia. Methods Chinese subjects (n ¼ 172, age: 11À65 years) were divided into diagnostic groups with non-myopia (spherical equivalence (SE)4À0.50 D), low (À3.00rSErÀ0.50 D), moderate (À6.00rSEoÀ3.00 D), and high myopia (SEoÀ6.00 D). Only the right eye of each subject was analyzed. Central corneal thickness (CCT) was measured by optical coherence tomography. An ocular response analyzer was used to measure corneal hysteresis (CH), corneal resistance factor (CRF), intraocular pressure (IOP), and corneal compensated IOP (IOPcc). Refraction was measured by both automated and subjective refractometry and expressed as SE. Results CH was significantly lower in high myopia compared with both low and non-myopia (Pr0.002). CCT was 1.5 times more correlated to CH variation compared with refraction. Similarly, CRF was four times more dependent on CCT than refraction. CH (Po0.001) or CRF (P ¼ 0.005) was positively correlated to refraction. Both IOP and IOPcc were negatively correlated to refraction (Po0.001), respectively. Conclusions CH decreases only in high myopia. Refraction is positively correlated to both CH and CRF but negatively correlated to both IOP and IOPcc. These results indicate that the mechanical strength in anterior segment of the eye is compromised in high myopia. In addition, high myopia may increase the risk of glaucoma.

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Section: Discussionmentioning

confidence: 99%

Association between corneal biomechanical properties and myopia in Chinese subjects

Jiang

Shen

Mao

et al. 2011

Eye

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“…Thinner central corneal thickness (CCT) was reported to be associated with retinal arteriolar narrowing in the SCORM study. 28 Furthermore, intraocular pressure (IOP) measurements by applanation tonometry are affected by central corneal thickness, corneal curvature, and axial length. 29 Interestingly, we found a very strong correlation between retinal venular caliber and corneal curvature across both models.…”

Section: Discussionmentioning

confidence: 99%

Relationship of Ocular Biometry and Retinal Vascular Caliber in Preschoolers

Cheung

Gazzard

Chang³

et al. 2011

Invest. Ophthalmol. Vis. Sci.

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“…In multivariable regression models, we introduced CRAE or CRVE as dependent variables and assessed their association with each lipid parameters: TG, TC, HDL-C, LDL-C, apoA1, apoB, and apoA1-to-apoB ratio (apoA1/apoB). Covariates including age, sex, MABP, axial length and the fellow vascular diameter (i.e., CRVE for CRAE outcomes and vice versa )4849 were adjusted. Based on the cutoff points set by the NHLBI in 20116, we divided the participants into subgroups (i.e.…”

Section: Methodsmentioning

confidence: 99%

Serum lipid profiles and dyslipidaemia are associated with retinal microvascular changes in children and adolescents

Xiao

Guo

Ding

et al. 2017

Sci Rep

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The present study aims to assess the relationship between serum lipid parameters and retinal microvascular calibres in children and adolescents. A total of 950 participants aged 7 to 19 years were recruited. Central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were measured from digital retinal images. Serological testing was performed to obtain lipid profiles. Dyslipidaemia was defined according to the US national expert panel guideline. After adjusted for age, sex, mean arterial blood pressure, axial length, body mass index and the fellow retinal vascular calibre, no significant association was found between retinal vascular diameters and any lipid parameters (all P > 0.05) in children younger than 12 years. Among the adolescents 12 years and older, increased triglycerides, total cholesterol, low-density lipoprotein cholesterol, and apoB were associated with decrease in CRAE (β = −1.33, −1.83, −1.92 and −7.18, P = 0.031, 0.003, 0.006, and 0.009, respectively). Compared with normolipidemic counterparts, adolescents with dyslipidaemia had significantly narrower retinal arteriolar diameters. No significant relationship between lipid subclass levels and CRVE was revealed in adolescents. The present findings suggest that the elevation of atherogenic lipids in adolescents is closely related to the adverse changes of retinal arterioles. Dyslipidaemia may affect systemic microvasculature from childhood on.

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Corneal Biomechanical Properties and Retinal Vascular Caliber in Children

Abstract: Lower CH and CRF are associated with narrower retinal arterioles in Singaporean children.

Cited by 17 publications

References 31 publications

Association between corneal biomechanical properties and myopia in Chinese subjects

Association between corneal biomechanical properties and myopia in Chinese subjects

Relationship of Ocular Biometry and Retinal Vascular Caliber in Preschoolers

Serum lipid profiles and dyslipidaemia are associated with retinal microvascular changes in children and adolescents

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