Corneal Biomechanics Determination in Healthy Myopic Subjects

Qiu, Kunliang; Lu, Xuehui; Zhang, Riping; Wang, Geng; Zhang, Mingzhi

doi:10.1155/2016/2793516

Cited by 19 publications

(19 citation statements)

References 46 publications

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“…We assumed that elongated myopic eyes have less rigidity to absorb external stress compared to emmetropic eyes, and thus, the globe tends to recoil backward faster. Our hypothesis is supported by previous ORA studies that showed lower corneal hysteresis in high myopia and suggested that myopic eyes had more flexibility and relative flaccidity [36][37][38][39]. Together with our data, the results suggest that the cornea in high myopia is less stiff than that in nonmyopia.…”

Section: Discussionsupporting

confidence: 91%

“…CH is a measurement of the energy absorption during the stress-strain cycle of viscoelastic composition which may represent the contribution of corneal resistance [34]. Studies from Shen et al and Qiu et al demonstrated that CH was significantly lower in high myopic eyes [35,36]. e Corvis ST enables real-time visualization of the corneal responses to applied external forces.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of Corneal Biomechanical Properties among Axial Myopic, Nonaxial Myopic, and Nonmyopic Eyes

Tubtimthong

Chansangpetch

Ratprasatporn

et al. 2020

BioMed Research International

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Purpose. To compare corneal deformation characteristics using ultra-high-speed Scheimpflug camera (Corvis ST) in patients with nonmyopic (NM), mild-to-moderate nonaxial myopic (MM), and high axial myopic (HM) eyes. Methods. In this cross-sectional study, normal subjects aged >40 years with no history of ocular laser/surgery were classified according to axial length (AL) and spherical equivalence (SE) into three groups: (1) NM (SE > −0.50 D and AL < 26 mm), (2) MM (SE −6.00 D to −0.50 D and AL < 26 mm), and (3) HM (SE ≤ −6.00 D and AL ≥ 26 mm). Seven parameters including corneal deformation amplitude (CDA), inward/outward corneal applanation length, inward/outward corneal velocity (ICV and OCV), peak distance, and radius were measured. Pearson correlation and linear mixed-effects model were done. Results. A total of 180 eyes were recruited. 98 eyes were NM, 30 eyes were MM, and 52 eyes were HM. There were significant correlations of OCV to the degree of refractive error (r = 0.203, p<0.001) and AL (r = −0.242, p<0.001). After adjusting for age, sex, intraocular pressure, and corneal thickness, there was significantly higher CDA (β = 0.07, p<0.001), faster OCV (β = −0.08, p<0.001), and smaller radius (β = −0.39, p=0.01) in the HM group compared to the NM group. Conclusion. The higher CDA, faster OCV, and smaller radius found in the HM may suggest that these eyes have reduced ocular stiffness and may be less stable and more prone to stress.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Comparison of Corneal Biomechanical Properties among Axial Myopic, Nonaxial Myopic, and Nonmyopic Eyes

Tubtimthong

Chansangpetch

Ratprasatporn

et al. 2020

BioMed Research International

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“…A previous study shows that CRF was significantly lower in highly myopic eyes compared with emmetropic eyes,40 although there is another study that suggested no relationship between AL and CRF 41. In the current study, CRF increased with the decrease of PRAA.…”

Section: Discussioncontrasting

confidence: 51%

Relationship Between the Shift of the Retinal Artery Associated With Myopia and Ocular Response Analyzer Waveform Parameters

Asano

Asaoka

Yamashita

et al. 2019

Trans. Vis. Sci. Tech.

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Purpose We have recently reported that the retinal stretch due to myopia is closely related to the peripapillary retinal arteries angle (PRAA) (Yamashita et al., Invest Ophthalmol Vis Sci 2013;54:5481–5488). The purpose of the current study was to investigate the relationship between retinal artery position and Ocular Response Analyzer (ORA) waveform parameters. Methods In 43 eyes of 41 healthy subjects, ORA measurements were carried out and the PRAA was calculated from fundus photographs. Then, the variables related to PRAA were identified from 40 variables of age, axial length (AL), keratometry, ORA corneal hysteresis (CH), ORA corneal resistant factor (CRF), and 35 ORA waveform parameters, using the Lasso regression and model selection with the second-order bias-corrected Akaike information criterion index. Results The optimal model for PRAA included AL, CRF, and three ORA waveform parameters (aindex, w2, and slew1). This optimal model was significantly better than the model with AL-only, the model only with AL and CH, and the model only with AL and CRF ( P < 0.0001, P < 0.0001, P < 0.0001, respectively; analysis of variance). Conclusions The PRAA was significantly better represented by using AL and ORA parameters including waveform parameters, compared with AL alone, with AL and CH alone, and with AL and CRF alone. Translational Relevance ORA waveform, which represents corneal biomechanical properties, was associated with myopic retinal stretch.

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“…For hyperopic and for female patients, higher values for CRF have been observed. For highly myopic patients, other studies have registered lower values of the CH and CRF and higher values of IOPcc (Corneal Compensated Intraocular Pressure) and of IOPg (Goldmann Correlated IOP value) compared to the emmetropic, hyperopic patients or patients with medium or low myopia [ 31 - 34 ].…”

Section: Discussionmentioning

confidence: 99%

Correlations between corneal biomechanics and specular microscopy in patient with cataract

Iancu

Bujor

Iliuţă

et al. 2020

rjo

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This study aimed to analyze the connection between corneal biomechanics (corneal hysteresis, CH) and endothelial cell density of cornea (mean endothelial cell density, MCD) in patients diagnosed with cataract. This retrospective, observational study was performed in the Ophthalmology Clinic of the University Emergency Hospital in Bucharest. Of 60 patients (120 eyes) with cataract, who were included in this study, we analyzed the CH values obtained using with the Ocular Response Analyzer (ORA) and the MCD values obtained using the specular microscopy. The study groups comprised both men and women with ages ranging from 45 to 63 years. Patients were divided into three study groups according to CH values. In each batch, the CH values obtained with the Ocular Response Analyzer (ORA) were correlated with age, gender and MCD, then the subgroups were compared. All the data gathered showed no correlation to be statistically significant regarding the biomechanical properties of the cornea and the corneal endothelial cell density in patients with cataract.

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Corneal Biomechanics Determination in Healthy Myopic Subjects

Cited by 19 publications

References 46 publications

Comparison of Corneal Biomechanical Properties among Axial Myopic, Nonaxial Myopic, and Nonmyopic Eyes

Comparison of Corneal Biomechanical Properties among Axial Myopic, Nonaxial Myopic, and Nonmyopic Eyes

Relationship Between the Shift of the Retinal Artery Associated With Myopia and Ocular Response Analyzer Waveform Parameters

Correlations between corneal biomechanics and specular microscopy in patient with cataract

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