Corneal collagen cross-linking in the treatment of infectious keratitis and corneal ulcers

Kasparova, Evg A; Sobkova, O I; Yang, Baoqi

doi:10.17116/oftalma20171336113-118

Cited by 4 publications

(2 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This diagnostic method is limited by material selection, and the positive rate is not high. [29][30][31] In recent years, endothelial plaques caused by infectious keratitis have gradually attracted the attention of ophthalmologists. Endothelial plaques were originally considered a characteristic sign of fungal keratitis.…”

Section: Discussionmentioning

confidence: 99%

Clinical Observation of Corneal Endothelial Plaques With Fungal and Bacterial Keratitis by Anterior Segment Optical Coherence Tomography and In Vivo Confocal Microscopy

Jin

Shi

et al. 2021

Cornea

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical Observation of Corneal Endothelial Plaques With Fungal and Bacterial Keratitis by Anterior Segment Optical Coherence Tomography and In Vivo Confocal Microscopy

Jin

Shi

et al. 2021

Cornea

View full text Add to dashboard Cite

show abstract

“…CXL controls infection by enhancing the biomechanical strength of the cornea and increasing collagen resistance to enzymatic hydrolysis (24,25). Although the effectiveness of CXL application on fungal corneal ulcers have been previously reported (26), its efficacy on infection control and ulcer healing requires further investigation in a larger population. In the present study, the CXL procedure was improved, following 4 min irradiation at 30 mW/cm 2 and a total dose of 7.2 J/cm 2 , its efficacy was evaluated.…”

Section: Discussionmentioning

confidence: 99%

Comparison of modified corneal cross-linking with intrastromal voriconazole for the treatment of fungal corneal ulcer

et al. 2021

View full text Add to dashboard Cite

The present study aimed to evaluate the efficacy of modified corneal cross-linking (CXL) for the treatment of fungal corneal ulcers compared with that following intrastromal voriconazole injection. In total, 31 patients with fungal corneal ulcers treated at The General Hospital of Northern Theater Command between October 2017 and October 2019 were enrolled. Among them, 10 eyes were treated with ultraviolet A (UV-A)/riboflavin CXL (CXL group), whilst 21 eyes were treated with debridement combined with intrastromal voriconazole (stromal injection group). Preoperative microbiological examination was performed in both groups, and evaluated using Fisher's exact test. Postoperatively, infection control and total efficacy rates, localized lesion, ulcer healing rate 1 week after surgery, visual acuity and complications were evaluated using Fisher's exact test, however visual acuity was analyzed by mixed-model ANOVA. The results showed that the pre-operative species distribution between the CXL and stromal injection groups did not significantly differ. The infection control rate in the CXL group was notably higher compared with that in the stromal injection group (P= 0.04). Furthermore, the total efficacy rate in the CXL group was also markedly higher compared with that in the stromal injection group, though no statistically significant differences were observed. Localized lesions were observed in nine eyes (90.0%) in the CXL group and nine eyes (42.9%) in the stromal injection group (P= 0.02). However, the rate of ulcer healing at 1 week postoperatively and the logarithm of the minimum angle of resolution (logMAR) of visual acuity were not found to be significantly different between the two groups. In terms of complications, with the exception of one patient in the CXL group exhibiting loss of corneal transparency and one patient in the stromal injection group presenting with partial corneal thinning, no other forms of complications were observed. In conclusion, the present study suggested that CXL could have a beneficial impact for treating fungal corneal ulcers in the aspects of infection control, localized lesions and accelerated epithelialization. In addition, except the loss of corneal transparency, this treatment approach could be applied with reduced risks of adverse events.

show abstract

Clinical results of modified crosslinking in the treatment of purulent keratitis and corneal ulcers

Kasparova¹,

Федоров²,

Yang³

2020

Vestn. oftal'mol.

View full text Add to dashboard Cite

Corneal collagen cross-linking in the treatment of infectious keratitis and corneal ulcers

Abstract: In recent years, collagen cross-linking (CXL) of the cornea has acquired a new usage - in the treatment of infectious keratitis and corneal ulcers. This review was aimed at compiling the previously published data and assessing the effectiveness of the method.

Cited by 4 publications

References 43 publications

Clinical Observation of Corneal Endothelial Plaques With Fungal and Bacterial Keratitis by Anterior Segment Optical Coherence Tomography and In Vivo Confocal Microscopy

Clinical Observation of Corneal Endothelial Plaques With Fungal and Bacterial Keratitis by Anterior Segment Optical Coherence Tomography and In Vivo Confocal Microscopy

Comparison of modified corneal cross-linking with intrastromal voriconazole for the treatment of fungal corneal ulcer

Clinical results of modified crosslinking in the treatment of purulent keratitis and corneal ulcers

Contact Info

Product

Resources

About