Corneal confocal microscopy and dry eye findings in contact lens discomfort patients

Doğan, Aysun Şanal; Gürdal, Canan; Arslan, Neşe

doi:10.1016/j.clae.2017.08.001

Cited by 31 publications

(36 citation statements)

References 22 publications

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“…33 Reports of subbasal nerve tortuosity have more consistently revealed an increase in DED. 11,12,[32][33][34] However, most of these studies used subjective grading systems, not quantifying tortuosity, thereby decreasing the reproducibility and clinical significance of their results. Therefore, in this study, we quantified corneal subbasal nerve tortuosity in DED using Tagg, an objective and aggregated measure of tortuosity, and evaluated its correlation with clinical parameters of DED.…”

Section: Discussionmentioning

confidence: 99%

Quantification of Increased Corneal Subbasal Nerve Tortuosity in Dry Eye Disease and Its Correlation With Clinical Parameters

Xie

Yang

et al. 2021

Trans. Vis. Sci. Tech.

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Section: Discussionmentioning

confidence: 99%

Quantification of Increased Corneal Subbasal Nerve Tortuosity in Dry Eye Disease and Its Correlation With Clinical Parameters

Xie

Yang

et al. 2021

Trans. Vis. Sci. Tech.

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“…According to previous studies, the damage of contact lens on ocular surface and tear lm can be summarized as: Firstly, the direct frictional effect on corneal and conjunctival tissues and cells. This kind of continuous friction leads to the damage of conjunctiva and corneal epithelial, causes the edema, necrosis and abscess of conjunctival epithelium or stromal cells near cornea and limbus, damages the natural barrier of ocular surface epithelial cells secondary in ltration of in ammatory cells including dendritic cells, releases various in ammatory factors, and causes keratitis [11,12]. The second is the effect on eyelid and meibomian gland.…”

Section: Discussionmentioning

confidence: 99%

A Questionnaire-Based Assessment of Functional Dry Eye Disease in Working-class Population in Shanghai, China

Wang

Chen

et al. 2021

Preprint

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Background To investigate the current status, morbidity, and risk factors of functional dry eye disease (DED) in Shanghai's working-class population. On this basis, exploring measures and methods to fundamentally cure and prevent functional DED. Methods A questionnaire form was used to record the data of the diagnosed functional DED working-class subjects in Shanghai, the results were recorded and analyzed. Additionally, the subjective symptoms of DED subjects and the respective clinical results were also recorded. The classification and corneal staining between subjects who wear contact lens or without were compared. The correlation of classification and corneal staining with their risk factors were also analyzed. Results The risk factors of functional DED showed much in common though their works have professional particularity. EDE accounts for a large proportion of DED (45.35%), many subjects coexist symptoms and signs of mixed DED (32.64%). The age of 21–40 is the peak year range (70.4%). Contact lens, visual terminals, air-conditioner, decoration, stay up later, sleep disorder, smoking were risk factors in most functional DED subjects. Notably, contact lens is a leading risk factor to cause functional DED and ocular surface complications (both were p < 0.01), while deep sleep seems to be a protective factor (p < 0.01%). Conclusion The incidence of functional DED in Shanghai is kept in a high level, most risk factors are closely related to daily work and life, while they are almost reversible. Exploring and eradicating these daily risk factors seems to be a more preferable way to fundamentally control and prevent functional DED.

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“…In this regard, the TFOS International Workshop on CLD has extensively reviewed the problem of CLD and associated dryness. According to recent findings, the mechanisms involved in CLD seem to share common pathways with DED [133][134][135] , initiating a closed loop of inflammation as described by Baudouin et al 136 When a CL is fitted on a patient's eye, TF is disturbed leading to an increase in evaporation rate and dewetting 137 and possibly impacting the function of the In addition, over the past decade there has been a resurgence of interest in scleral CLs (SCLs). SCLs are large-diameter rigid gas permeable CLs that vault the cornea and limbus and are supported by the sclera.…”

Section: Contact Lensesmentioning

confidence: 99%

Presbyopia and the aging eye: Existing refractive approaches and their potential impact on dry eye signs and symptoms

Lafosse

Wolffsohn

Talens‐Estarelles

et al. 2020

Contact Lens and Anterior Eye

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Every part of the human body is subject to aging, including the eye. An increased 3 prevalence of dry eye disease with age is widely acknowledged. Aging threatens 4 ocular surface homeostasis, altering the normal functioning of the lacrimal 5 functional unit and potentially leading to signs and symptoms of dry eye. 6 Additional age-related processes take place within the crystalline lens, leading to 7 presbyopia and cataractogenesis. Correction strategies for presbyopia and 8 cataracts may directly or indirectly challenge the ocular surface. Contact lenses 9 disturb the normal structure of the tear film and can interact negatively with the ocular surface, further deteriorating an already unbalanced tear film in presbyopes, however, newer contact lens designs can overcome some of these issues. Moreover, cataract and corneal refractive surgeries sever corneal nerves and disrupt the corneal epithelium and ocular surface, which can influence surgical outcomes and aggravate dryness symptoms in older age groups. This review summarises the current understanding of how the invasive nature of contact lens wear and cataract and refractive surgery influence signs and symptoms of ocular dryness in an aging population.

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Corneal confocal microscopy and dry eye findings in contact lens discomfort patients

Cited by 31 publications

References 22 publications

Quantification of Increased Corneal Subbasal Nerve Tortuosity in Dry Eye Disease and Its Correlation With Clinical Parameters

Quantification of Increased Corneal Subbasal Nerve Tortuosity in Dry Eye Disease and Its Correlation With Clinical Parameters

A Questionnaire-Based Assessment of Functional Dry Eye Disease in Working-class Population in Shanghai, China

Presbyopia and the aging eye: Existing refractive approaches and their potential impact on dry eye signs and symptoms

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