Corneal Contact Times of Ophthalmic Vehicles

Trueblood, Jon H.; Rossomondo, Roger M.; Carlton, William H.; Wilson, Louis A.

doi:10.1001/archopht.1975.01010020133008

Cited by 47 publications

(11 citation statements)

References 6 publications

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“…These vehicles were saline, polyvinyl alcohol and hydroxy propyl methyl cellulose. Longest contact time was observed with hydroxy propyl methyl cellulose compared with other vehicles [94]. Saettone et al had shown the effect of different polymers on the pharmacological activity of pilocarpine in rabbit and man.…”

Section: Eye Drops (Solutions Emulsions and Suspensions)mentioning

confidence: 98%

Review of Ocular Drug Delivery

Sultana

Jain

Aqil³

et al. 2006

CDD

123

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Successful treatment of eye diseases requires effective concentration of drug at the eye for sufficient period of time. Conventional ocular drug delivery including eye drops, systemic administration, ophthalmic ointments, is no longer sufficient to combat ocular diseases. This article reviews the constraints with conventional ocular therapy, and explores various novel approaches, to improve the ocular bioavailability of drugs to the anterior chamber of the eye.

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Section: Eye Drops (Solutions Emulsions and Suspensions)mentioning

confidence: 98%

Review of Ocular Drug Delivery

Sultana

Jain

Aqil³

et al. 2006

CDD

123

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“…unnoticed expulsion from the eye, membrane ruptures etc.). A number of ocular inserts were prepared utilizing different techniques to make soluble, erodible, nonerodible, and hydrogel inserts [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] .…”

Section: Ocular Insertsmentioning

confidence: 99%

Occular Drug Delivery System: An Overview

Ara¹,

Bundela²,

Nimb³

et al. 2017

Curr. Res. Pharm. Sci.

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Delivery of drugs to the targeted ocular tissues is restricted by various precorneal, dynamic and static ocular barriers. Also, therapeutic drug levels are not maintained for longer duration in target tissues. In the past two decades, ocular drug delivery research acceleratedly advanced towards developing a novel, safe and patient compliant formulation and drug delivery devices/techniques, which may surpass these barriers and maintain drug levels in tissues. Anterior segment drug delivery advances are witnessed by modulation of conventional topical solutions with permeation and viscosity enhancers. Also, it includes development of conventional topical formulations such as suspensions, emulsions and ointments. On the other hand, for posterior ocular delivery, research has been immensely focused towards development of drug releasing devices and nanoformulations for treating chronic vitreoretinal diseases. These occuserts formulations may help to surpass ocular barriers and associated side effects with conventional topical drops. Also, these novel devices and/or formulations are easy to formulate, no/negligibly irritating, possess high precorneal residence time, sustain the drug release, and enhance ocular bioavailability of therapeutics. An update of current research advancement in ocular drug delivery necessitates and helps drug delivery scientists to modulate their think process and develop novel and safe drug delivery strategies.

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“…The time interval for administration may be widened if suitable viscosity inducing compounds, e.g. methylcellulose or polyvinyl alcohol, are added to the formulation (Magrane, 1977;Trueblood et al, 1975), or the active is administered as an ointment. Ointments remain in the eye longer than do solutions, both in the precorneal tear, film and the conjunctival fornices, thereby increasing absorption of active ingredients (Campbell, 1979).…”

Section: (7)mentioning

confidence: 99%

Physico‐chemical and formulation‐induced veterinary drug‐product bioinequivalencies

Pope

1984

Vet Pharm & Therapeutics

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Corneal Contact Times of Ophthalmic Vehicles

Cited by 47 publications

References 6 publications

Review of Ocular Drug Delivery

Review of Ocular Drug Delivery

Occular Drug Delivery System: An Overview

Physico‐chemical and formulation‐induced veterinary drug‐product bioinequivalencies

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