Corneal deflection amplitude and visual field progression in primary open-angle glaucoma

Jung, Younhea; Chun, Heejeong; Moon, Jooho

doi:10.1371/journal.pone.0220655

Cited by 9 publications

(9 citation statements)

References 31 publications

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“…In accordance, using CST measurements Li et al found a more deformable cornea in the worse eye of asymmetric NPG patients [ 12 ]. In the same manner, Jung et al reported a quicker progression of perimetric defects in case of a higher deflection amplitude [ 70 ] indicating a reduced corneal stiffness [ 24 , 25 , 71 ]. And Park et al showed lower CH values in more advanced glaucoma classified by HRT measurements [ 34 ].…”

Section: Discussionmentioning

confidence: 90%

Evaluation of corneal biomechanical properties using the ocular response analyzer and the dynamic Scheimpflug-Analyzer Corvis ST in high pressure and normal pressure open-angle glaucoma patients

et al. 2023

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Purpose To characterize differences in corneal biomechanics in high (HPG) and normal pressure (NPG) primary open-angle glaucoma, and its association to disease severity. Methods Corneal biomechanical properties were measured using the Ocular Response Analyzer (ORA) and the dynamic Scheimpflug-Analyzer Corvis ST (CST). Disease severity was functionally assessed by automated perimetry (Humphrey field analyzer) and structurally with the Heidelberg Retina Tomograph. To avoid a possible falsification by intraocular pressure, central corneal thickness and age, which strongly influence ORA and CST measurements, group matching was performed. Linear mixed models and generalized estimating equations were used to consider inter-eye correlation. Results Following group matching, 60 eyes of 38 HPG and 103 eyes of 60 NPG patients were included. ORA measurement revealed a higher CRF in HPG than in NPG (P < 0.001). Additionally, the CST parameter integrated radius (P < 0.001) was significantly different between HPG and NPG. The parameter SSI (P < 0.001) representing corneal stiffness was higher in HPG than in NPG. Furthermore, regression analysis revealed associations between biomechanical parameters and indicators of disease severity. In HPG, SSI correlated to RNFL thickness. In NPG, dependencies between biomechanical readings and rim area, MD, and PSD were shown. Conclusion Significant differences in corneal biomechanical properties were detectable between HPG and NPG patients which might indicate different pathophysiological mechanisms underlying in both entities. Moreover, biomechanical parameters correlated to functional and structural indices of diseases severity. A reduced corneal deformation measured by dynamic methods was associated to advanced glaucomatous damage.

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Section: Discussionmentioning

confidence: 90%

Evaluation of corneal biomechanical properties using the ocular response analyzer and the dynamic Scheimpflug-Analyzer Corvis ST in high pressure and normal pressure open-angle glaucoma patients

et al. 2023

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“…Iris furrows are the sites where the iris folded and contracted as protuberant lines on the peripheral iris. Previous literature only supports indirect relationships between iris surface features and iris biomechanics in glaucoma studies [ 13 , 14 ]. For example, in a finite element study of patients with a history of angle closure glaucoma, iris stiffness was higher in the patients than that in healthy participants [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Iris Biological Features and Corneal Biomechanics in Myopic Eyes

Фу

Dai

Zhu³

et al. 2021

Disease Markers

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Purpose. Iris biological features such as surface features and profile characteristics reflected the development of iris stroma and microvessels. Iris vessels and microcirculation are still lack of effective detection methods, and we can directly observe only the iris surface biological characteristics. This cross-sectional study evaluated the association between iris surface biological features and corneal biomechanics in young adults with myopia. Methods. We recruited 152 patients with myopia aged ≥18 years, from the Eye Hospital of Wenzhou Medical University, who had complete Corneal Visualization Scheimpflug Technology (Corvis ST) data and graded iris surface features. Iris surface features included crypts, furrows, and color measured from digital slit lamp images. The biomechanical properties of the cornea were assessed using Corvis ST. Only 1 eye of each participant was randomly selected for analysis. Associations between the iris surface features and corneal biomechanics were analyzed using linear regression models. The grade of iris crypts, furrows, and color and corneal biomechanical parameters measured with Corvis ST was the main outcome measures. Results. The iris crypts were significantly associated with deflection amplitude at the first applanation (A1 DLA, β = 0.001 , P = 0.013 ), A1 delta arc length (A1 dArcL) ( β = − 0.001 , P = 0.01 ), maximum delta arc length (dArcLM) ( β = − 0.004 , P = 0.03 ), and stiffness at the first applanation (SP-A1) ( β = − 2.092 , P = 0.016 ). The iris furrows were only associated with integrated radius ( β = − 0.212 , P = 0.025 ). Iris color was found not related with corneal biomechanical parameters measured via Corvis ST. Conclusions. Iris surface features were associated with corneal biomechanical properties in myopic eyes; more iris crypts were associated with lower corneal stiffness while more extensive furrows were related with higher corneal stiffness. Iris crypts and furrows may provide useful information on corneal biomechanical properties in myopic eyes.

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“…Erst die Verrechnung mehrerer Parameter hat zum Dresdner Biomechanischen Glaukom Faktor geführt [47], der allerdings nur für das Normaldruckglaukom gilt. Für das POWG konnte gezeigt werden, dass eine größere Deflektionsamplitude mit einer größeren Progressionsgeschwindigkeit einhergeht [48].…”

Section: Korneale Biomechanikunclassified

“…Only the inclusion of several parameters has led to the Dresden biomechanical glaucoma factor [47], which, however, only applies to normal pressure glaucoma. For POAG, it has been shown that a greater deflection amplitude is associated with a greater rate of progression [48].…”

Section: Corneal Biomechanicsmentioning

confidence: 99%

Einflussnahme des Diabetes mellitus auf glaukomrelevante Untersuchungsergebnisse beim primären Offenwinkelglaukom

Erb,

Kazakov

et al. 2023

Klin Monbl Augenheilkd

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ZusammenfassungDas primäre Offenwinkelglaukom (POWG) wird nicht mehr als eine isolierte augendruckabhängige Optikusneuropathie, sondern als eine neurodegenerative Erkrankung angesehen, bei der der oxidative Stress und die Neuroinflammation im Vordergrund stehen. Diese Prozesse können durch zusätzlich vorliegende Systemerkrankungen verstärkt werden. Am häufigsten kommen eine arterielle Hypertonie, Dyslipidämien und ein Diabetes mellitus vor. Anhand des Diabetes mellitus soll gezeigt werden, wie weitreichend eine derartige Systemerkrankung sowohl auf die funktionellen als auch auf die strukturellen diagnostischen Methoden für das POWG einen Einfluss nehmen kann. Diese Kenntnisse sind essenziell, da durch diese Interferenzen Fehlinterpretationen zum POWG denkbar sind, die auch Therapieentscheidungen betreffen können.

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Corneal deflection amplitude and visual field progression in primary open-angle glaucoma

Cited by 9 publications

References 31 publications

Evaluation of corneal biomechanical properties using the ocular response analyzer and the dynamic Scheimpflug-Analyzer Corvis ST in high pressure and normal pressure open-angle glaucoma patients

Evaluation of corneal biomechanical properties using the ocular response analyzer and the dynamic Scheimpflug-Analyzer Corvis ST in high pressure and normal pressure open-angle glaucoma patients

Association between Iris Biological Features and Corneal Biomechanics in Myopic Eyes

Einflussnahme des Diabetes mellitus auf glaukomrelevante Untersuchungsergebnisse beim primären Offenwinkelglaukom

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