Corneal Densitometry in Healthy Corneas and Its Correlation With Endothelial Morphometry

Abstract

Corneal densitometry might have potential to be used as an indicator of the health of corneal endothelium in the future.

One-year natural course of corneal densitometry in high myopic patients after implantation of an implantable collamer lens (model V4c)

“…Corneal densitometry assessments by using a Pentacam HR are able to detect various abnormalities in a wider zone than is a specular microscope. Corneal densitometry analysis may be employed to assess endothelial function in peripheral zones [2,4,9,10].…”

“…Studies have reported that corneal diseases such as keratitis [5], corneal epithelial oedema [6], Fuchs' endothelial corneal dystrophy [7] and keratoconus [8] can compromise corneal clarity, thus leading to an increase in corneal densitometry. The normal function of corneal endothelium and the regular arrangement of stromal layers play important roles in maintaining corneal clarity [9]. Otri AM [10] has noted that corneal densitometry can be used as an indicator of corneal heath.…”

The effect of corneal infiltrates on densitometry and higher‐order aberrations

“…Corneal densitometry values are expressed as the pixel luminance per unit volume in the Scheimpflug image, and are expressed in greyscale units (GSUs) (Figures A–B). The measurements range from zero (maximum transparency) to 100 (completely opaque cornea) according to the degree of backscattering light from the cornea …”

“…The corneal epithelial layer and the corneal endothelium are the major sources of corneal light scattering. Irregular interfaces between the corneal layers can cause glare and decreased visual acuity owing to increased light backscattering . Disruption of the corneal collagen matrix during oedema and the resultant corneal scarring can provoke an increase in corneal light scattering .…”

“…Irregular interfaces between the corneal layers can cause glare and decreased visual acuity owing to increased light backscattering . Disruption of the corneal collagen matrix during oedema and the resultant corneal scarring can provoke an increase in corneal light scattering . Additionally, several reasons such as corneal infiltrates, corneal deposits, and corneal ectatic disorders may be reasons for increased light backscattering …”