Corneal Ectasia After LASIK Combined With Prophylactic Corneal Cross-linking

Taneri, Suphi; Kießler, Saskia; Rost, Anika; Dick, H. Burkhard

doi:10.3928/1081597x-20161019-03

Cited by 12 publications

(8 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients' mean age was 30. 22 Efficacy in terms of distance cumulative Snellen visual acuity (20/x or better) is presented in Figure 1A. In total, 98% of the eyes obtained 20/25 or better, 87% of the eyes obtained 20/20 or better, and 11% of the eyes obtained 20/16 or better.…”

Section: Resultsmentioning

confidence: 96%

“…In their study, the intensity was 18 mW, while in ours, it was 30 mW and the treatment time was only 90 s. No study, including ours, has reported ectasia in prophylactic CXL and LASIK. However, Taneri et al [22] described a young patient that developed unilateral corneal ectasia after undergoing a combined surgery of LASIK and prophylactic CXL, and with a normal presurgical ophthalmic examination. Consequently, from the currently available literature, only one case out of 638 eyes treated with prophylactic CXL and LASIK developed an iatrogenic ectasia.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prophylactic Corneal Cross-Linking in Myopic Femtosecond Laser-Assisted In Situ Keratomileusis: Long-Term Visual and Refractive Outcomes

Alonso-Aliste

Amián-Cordero

Rachwani-Anil

et al. 2021

Optics

View full text Add to dashboard Cite

The purpose of our study was to evaluate the safety, effectiveness, predictability, and stability of myopic and astigmatic laser-assisted in situ keratomileusis (LASIK) with simultaneous prophylactic corneal cross-linking (CXL) in thin corneas. In total, 100 eyes from 50 patients who were subjected to myopic and astigmatism femtosecond LASIK with simultaneous prophylactic CXL were included. The design of the study was retrospective, longitudinal, and observational. All patients had a 48-month follow-up. The MEL 80 excimer laser was utilized with the Aberration Smart Ablation platform. CXL treatment was applied when the predicted stromal thickness was less than 330 µm. Patients’ mean age was 30.22 ± 5.97 years. Previous mean spherical equivalent was −5.50 ± 1.65 (−9.50 to −1.13) diopters (D). Postoperative mean spherical equivalent was −0.24 ± 0.29 (−0.85 to +0.50) D. Visual acuity (VA) of 20/20 or better was observed in 87% of the eyes and no eyes experienced VA loss. Spherical equivalent within ±0.50 D was observed in 93% of eyes, and 4% of eyes varied by 0.50 D or more between 3 and 48 months. Prophylactic corneal cross-linking with simultaneous femtosecond laser-assisted in situ keratomileusis in thin corneas proved to be effective, safe, and predictable. The results remained stable after 48 months of follow-up.

show abstract

Section: Resultsmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Prophylactic Corneal Cross-Linking in Myopic Femtosecond Laser-Assisted In Situ Keratomileusis: Long-Term Visual and Refractive Outcomes

Alonso-Aliste

Amián-Cordero

Rachwani-Anil

et al. 2021

Optics

View full text Add to dashboard Cite

show abstract

“…Lee et al compared the new DCR parameters from Corvis ST before and after combining TransPRK with prophylactic crosslinking (30 mW/cm 2 , 90 s, 2.7 J/cm 2 ) and found that prophylactic crosslinking diminishes the impairment in corneal biomechanics after TransPRK compared with cases that did not undergo CXL (Lee et al, 2017). However, since a biomechanics impairment was still evident in the crosslinked cases, the Xtra procedures did not seem to ensure ectasia does not happen (Taneri et al, 2017). In this study, SSI, which represents the biomechanical stiffness of corneal material (Eliasy et al, 2019), increased by around 15% in all groups when compared with preoperative, confirming that the Xtra procedures were effective in restoring at least part of the loss in biomechanics caused by the procedure.…”

Section: Discussionmentioning

confidence: 99%

Effect of fluence levels on prophylactic corneal cross‐linking for laser in situ keratomileusis and transepithelial photorefractive keratectomy

Hafezi

Torres-Netto

et al. 2022

Acta Ophthalmologica

View full text Add to dashboard Cite

Purpose The purpose of this study is to assess the effect of various fluence levels on prophylactic corneal cross‐linking (CXL) combined with femtosecond laser in situ keratomileusis (FS‐LASIK‐Xtra) or transepithelial photorefractive keratectomy (TransPRK‐Xtra) on biomechanics, demarcation line (DL), and stromal haze. Methods Prospective analysis where two prophylactic CXL protocols (lower/higher fluence [LF/HF]: 30 mw/cm2, 60/80 s, 1.8/2.4 J/cm2) were performed as part of either an FS‐LASIK‐Xtra or TransPRK‐Xtra procedure. Data were collected preoperatively and at 1 week and 1, 3, and 6 months postoperatively. Main outcome measures were (1) dynamic corneal response parameters and the stress–strain index (SSI) from Corvis, (2) actual DL depth (ADL), and (3) stromal haze on OCT images analysed by a machine learning algorithm. Results Eighty‐six eyes from 86 patients underwent FS‐LASIK‐Xtra‐HF (21 eyes), FS‐LASIK‐Xtra‐LF (21 eyes), TransPRK‐Xtra‐HF (23 eyes), and TransPRK‐Xtra‐LF (21 eyes). SSI increased similarly by around 15% in all groups 6 months postoperatively (p = 0.155). All other corneal biomechanical parameters were statistically significant worsening postoperatively, but the change was similar in all groups. At 1 month postoperatively, there was no statistical difference in mean ADL among four groups (p = 0.613), mean stromal haze was similar between the two FS‐LASIK‐Xtra groups, but higher in the TransPRK‐Xtra‐HF group compared with the TransPRK‐Xtra‐LF group. Conclusions FS‐LASIK‐Xtra and TransPRK‐Xtra lead to a similar ADL and improve SSI equally. Lower fluence prophylactic CXL might be recommended as it achieves similar mean ADL with potentially less induced stromal haze, especially in TransPRK. The clinical relevance and applicability of such protocols remains to be assessed.

show abstract

“…Recently, it was found that human corneas are weakened by only approximately 10% following creation of a 90-lm flap. 22 The need for optimization of the CXL-treatment after LASIK is supported by a very recent case report 23 describing a postoperative ectasia after LASIK Xtra. The eye was treated using 0.22% riboflavin for 90 seconds and after rinsing of the interface a radiant exposure of only 2.7 J/cm 2 was applied.…”

Section: Discussionmentioning

confidence: 99%

Interface Bonding With Corneal Crosslinking (CXL) After LASIK Ex Vivo

Seiler

Engler

Beck

et al. 2017

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

Corneal Ectasia After LASIK Combined With Prophylactic Corneal Cross-linking

Abstract: This report illustrates that the currently used prophylactic CXL protocol in combination with LASIK may not be effectively preventing corneal ectasia in every case. [J Refract Surg. 2017;33(1):50-52.].

Cited by 12 publications

References 11 publications

Prophylactic Corneal Cross-Linking in Myopic Femtosecond Laser-Assisted In Situ Keratomileusis: Long-Term Visual and Refractive Outcomes

Prophylactic Corneal Cross-Linking in Myopic Femtosecond Laser-Assisted In Situ Keratomileusis: Long-Term Visual and Refractive Outcomes

Effect of fluence levels on prophylactic corneal cross‐linking for laser in situ keratomileusis and transepithelial photorefractive keratectomy

Interface Bonding With Corneal Crosslinking (CXL) After LASIK Ex Vivo

Contact Info

Product

Resources

About