Corneal edema after cataract surgery: Incidence and etiology

Yi, David H.; Dana, M. Reza

doi:10.1076/soph.17.3.110.14737

Cited by 13 publications

(22 citation statements)

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“…Normally, the quiescent corneal endothelial cell population gradually diminishes over the human life span (reviewed by Joyce, 2003). Corneal dystrophies (most notably Fuchs' dystrophy) and intraocular surgeries (including phacoemulsification) greatly accelerate this process (Yi and Dana, 2002). Decreased endothelial cell density eventually leads corneal edema and opacity, often necessitating penetrating keratoplasty.…”

Section: Corneal Endothelial Fluid Transportmentioning

confidence: 99%

Functions of aquaporins in the eye

Verkman

Ruiz-Ederra

Levin

2008

Progress in Retinal and Eye Research

172

117

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The aquaporins (AQPs) are integral membrane proteins whose main function is to transport water across cell membranes in response to osmotic gradients. At the ocular surface, AQP1 is expressed in corneal endothelium, AQP3 and AQP5 in corneal epithelium, and AQP3 in conjunctival epithelium. AQPs are also expressed in lens fiber cells (AQP0), lens epithelium (AQP1), ciliary epithelium (AQP1, AQP4) and retinal Müller cells (AQP4). Mutations in AQP0 produce congenital cataracts in humans. Analysis of knockout mice lacking individual AQPs suggests their involvement in maintenance of corneal and lens transparency, corneal epithelial repair, intraocular pressure regulation, retinal signal transduction and retinal swelling following injury. The mouse phenotype findings implicate AQPs as potential drug targets for therapy of elevated intraocular pressure and ocular disorders involving the cornea, lens and retina. However, much research remains in defining cell-level mechanisms for the ocular AQP functions, in establishing the relevance to human eye disease of conclusions from knockout mice, and in developing AQPmodulating drugs.

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Section: Corneal Endothelial Fluid Transportmentioning

confidence: 99%

Functions of aquaporins in the eye

Verkman

Ruiz-Ederra

Levin

2008

Progress in Retinal and Eye Research

172

117

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“…2 Mechanical injuries are seen more frequently as a cause of corneal edema postoperatively. Fracture of IOL haptic and pseudophakic fragments is a rare complication of corneal edema due to cataract surgery.…”

Section: Discussionmentioning

confidence: 99%

A Rare Entity of Postoperative Progressive Corneal Edema: An Intruder at Iridocorneal Angle: Case Report

Helvaci¹

2017

Turkiye Klinikleri J Ophthalmol

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198 oldable intraocular lenses (IOLs) have the advantages of easy implantation that can be accomplished through a 2.4-2.8 mm corneal incision. Although it's easy implantation technique; haptics of the IOL may be easily damaged and broken unconsciously. A hidden broken piece of haptic may cause endothelial cell loss and endothelial dysfunction by stimulating cell migration from the central cornea to periphery. 1 We describe a case of unexplained postoperative corneal edema. This case highlights the importance of detailed iridocorneal angle examination, in order to prevent a corneal decompensation. A Rare Entity of Postoperative ProgressiveCorneal Edema: An Intruder at Iridocorneal Angle: Case Report A AB BS ST TR RA AC CT T A 70-year-old man developed an unexplained corneal edema in his right eye, 6 months after cataract extraction and implantation of a single piece hydrophilic acrylic posterior chamber intraocular lens in one week duration. The patient noted decreased vision and severe pain in his right eye and denied a trauma history after the cataract surgery. Since the edema was especially located at the inferior cornea; keeping a foreign body in mind, gonioscopy was performed. In our case the reason of the corneal edema was a broken haptic piece. In case of omitting the gonioscopy and missing a foreign body, may cause a corneal decompensation and a probable corneal transplantation. This case highlights the importance of keeping broken haptics in mind as a reason of corneal endothelial irritation. K Ke ey yw wo or rd ds s: : Corneal endothelial cell loss; gonioscopy; lenses, intraocular Ö ÖZ ZE ET T Yetmiş yaşındaki erkek hastada bir hafta süre içinde sağ gözünde, katarakt cerrahisi ve tek parçalı arka kamara hidrofilik akrilik lensi implantasyonundan 6 ay sonra başta açıklanamayan korneal ödem gelişti. Hasta sağ gözünde görme azalması ve şiddetli ağrı olduğunu kaydetti ve katarakt cerrahisinden sonra bir travma hikayesini reddetti. Korneal ödem özellikle alt korneal yarıda geliştiği için, yabancı bir cisimi akılda tutarak hastaya gonyoskopi yapıldı. Bizim vakamızda korneal ödemin sebebi kırık bir haptik parçasıydı. Gonyoskopinin ihmal edilmesi ve bir yabancı cismin atlanması, bir korneal dekompansasyona ve muhtemel bir kornea transplantasyonuna sebep olabilir. Bu vaka korneal endotelyal irritasyon sebepleri arasında kırık haptik parçalarını akılda tutmanın önemini vurguluyor.A An na ah ht ta ar r K Ke el li im me el le er r: : Korneanın endotel hücre kaybı; goniyoskopi; lensler, göz içi

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“…41 Post-operative inflammation has been identified as a cause of persistent post-operative corneal oedema following cataract surgery. 14,42,43 Persistent corneal inflammation and vascularisation increase the risk of corneal graft rejection after keratoplasty for post-operative corneal decompensation. 43 Hence, these immune modulatory properties of honey may be of benefit in the management of post-graft eyes in the prevention and management of corneal graft rejection as illustrated in Figure 5.…”

Section: Casementioning

confidence: 99%

“…14 Persistent corneal oedema or corneal decompensation following cataract surgery occurs in approximately 0.5 per cent of cases. 14 In a high-volume cataract surgical clinic, a case of persistent post-operative corneal oedema would be expected to be encountered every few months. Hence strategies to manage this corneal oedema, including novel strategies, should be evaluated and employed if deemed safe and efficacious.…”

mentioning

confidence: 99%

Standardised antibacterial Manuka honey in the management of persistent post‐operative corneal oedema: a case series

Albietz

Lenton

2015

Clinical and Experimental Optometry

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Background: Corneal oedema is a common post-operative problem that delays or prevents visual recovery from ocular surgery. Honey is a supersaturated solution of sugars with an acidic pH, high osmolarity and low water content. These characteristics inhibit the growth of microorganisms, reduce oedema and promote epithelialisation. This clinical case series describes the use of a regulatory approved Leptospermum species honey ophthalmic product, in the management of post-operative corneal oedema and bullous keratopathy. Methods: A retrospective review of 18 consecutive cases (30 eyes) with corneal oedema persisting beyond one month after single or multiple ocular surgical procedures (phacoemulsification cataract surgery and additional procedures) treated with Optimel Antibacterial Manuka Eye Drops twice to three times daily as an adjunctive therapy to conventional topical management with corticosteroid, aqueous suppressants, hypertonic sodium chloride five per cent, eyelid hygiene and artificial tears. Visual acuity and central corneal thickness were measured before and at the conclusion of Optimel treatment. Results: A temporary reduction in corneal epithelial oedema lasting up to several hours was observed after the initial Optimel instillation and was associated with a reduction in central corneal thickness, resolution of epithelial microcysts, collapse of epithelial bullae, improved corneal clarity, improved visualisation of the intraocular structures and improved visual acuity. Additionally, with chronic use, reduction in punctate epitheliopathy, reduction in central corneal thickness and improvement in visual acuity were achieved. Temporary stinging after Optimel instillation was experienced. No adverse infectious or inflammatory events occurred during treatment with Optimel. Conclusions: Optimel was a safe and effective adjunctive therapeutic strategy in the management of persistent post-operative corneal oedema and warrants further investigation in clinical trials.

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Corneal edema after cataract surgery: Incidence and etiology

Cited by 13 publications

References 0 publications

Functions of aquaporins in the eye

Functions of aquaporins in the eye

A Rare Entity of Postoperative Progressive Corneal Edema: An Intruder at Iridocorneal Angle: Case Report

Standardised antibacterial Manuka honey in the management of persistent post‐operative corneal oedema: a case series

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