Corneal Healing After Riboflavin Ultraviolet-A Collagen Cross-Linking Determined by Confocal Laser Scanning Microscopy In Vivo: Early and Late Modifications

Effects of Corneal Crosslinking for Keratoconus Assessed with Anterior Segment Optical Coherence Tomography

“…This finding might correlate with the confocal microscopy observations of increase in the extracellular matrix reflectivity and keratocyte hyperplasia in the anterior stroma [9][10]. Surprisingly, some patients also showed incomplete secondary hyperreflective lines at variable depths, which due to their parallel disposition to stromal lamellae and progressive attenuation might reflect local differences in treatment effect within the stroma.…”

Corneal Cross Linking with Riboflavin for Progressive Keratoconus in Paediatric Eyes

“…In both groups there was increase in average K at one month followed by a decrease at 3 and 6 months. This was similar to the trend reported by Vinciguerra et al [21] and Hersh et al [22] (Figure 7) but in contrast to continued decrease in average K postoperatively as reported by Caporossi et al [17] and Raiskup-Wolf et al [18] Confocal microscopy post crosslinking shows a time dependent stratification of the corneal epithelium after three months of the procedure [23]. This corresponds to a smoothening of the surface irregularities as the epithelium remodels/heals.…”

“…In the older Group, reduction in thinnest pachymetry was lesser in magnitude (mean change −38.72 µm, p < 0.0001; and −31.0 µm, p < 0.0001 at three and six months respectively) but statistically significant. This reduction in thinnest pachymetry can be attributed to measurement artifact as it has been shown that optical pachymetry is affected negatively by the non-homogen- ous optical changes seen in crosslinked corneas (due to corneal haze/demarcation line/stromal edema) [23] [24]. The Siena Study group [17] compared pachymetric results of the optical Obrscan IIz with ultrasound pachymetry and confocal pachymetric examinations and found a significant underestimation (−120 µm in the first six months) of corneal thickness with the Orbscan IIz.…”

Tensioactive-mediated Transepithelial Corneal Cross-linking – First Laboratory Report

“…11 It is estimated that re-epithelialisation requires at least four days to complete and up to three months for qualitative improvement of the epithelial cell mosaic compared with the pre-operative state by confocal microscopy. 12 In the period of re-epithelialisation there is an accompanying stromal oedema. …”