Corneal melt in lattice corneal dystrophy type II after cataract surgery

Papathanassiou, Miltiadis; Liarakos, Vasilios S.; Vaikousis, Emmanuel; Paschalidis, Thrasivoulos; Agrogiannis, George; Vergados, Ioannis

doi:10.1016/j.jcrs.2008.07.039

Cited by 9 publications

(5 citation statements)

References 24 publications

(19 reference statements)

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“…23,24 The use of subconjunctival and intravitreal anti-VEGF has been associated with the reduction of corneal nerve parameters 25 and with corneal neurotrophic factors content decrease in mice. 26 In the current case bevacizumab (5 mg/ml) was introduced 6 weeks after the infectious keratitis on the left eye twice a day. It was well tolerated by the patient and showed regression of deep stromal vessels.…”

Section: Discussionmentioning

confidence: 98%

“…22,25 However, in end stage disease when complete corneal anesthesia is present as the current case, surgical indications should be cautious due to the possible poor healing process. 26 Penetrating keratoplasty in LCD II was complicated by a neurotrophic persistent epithelial defect and delayed graft epithelial healing. 22 In Mattila et al serie, 25 graft failure occurred in 16 of 31 eyes known cases of familial amyloidosis and resulted from surface complications in 11 eyes and additionally from rejection in 5 eyes.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Contact lens induced bacterial keratitis in LCD II: Management and multimodal imaging: a case report and review of literature

Alafaleq

Knoeri

Boutboul

et al. 2020

European Journal of Ophthalmology

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Purpose: To describe the management and multimodal imaging of lattice corneal dystrophy type II (LCD-II) complicated by an infectious keratitis due to a bandage contact lens and to review current literature. Observation: A 50-year-old female was diagnosed with Meretoja’s Syndrome by the triad of facial palsy, loose skin (cutix laxa), and stromal corneal dystrophy. At slit lamp, bilateral lattice corneal dystrophy (LCD) was characterized by multiple linear refractile lines and subepithelial fibrosis along with Neurotrophic keratitis Mackie grade I. Findings of anterior segment optical coherence tomography (AS-OCT) were epithelial irregularity, subepithelial fibrosis, hyperreflectivity on anterior stromal layer, lobulated stromal surface. In vivo confocal microscopy (IVCM) showed hyperreflected deposits on the basal and Bowman layers, visible keratocytes; fine lines and streaks between corneal lamella. The sub-basal nerve plexus and the stromal nerves were no longer visible. She presented in emergency with a left red eye. A severe bacterial keratitis was diagnosed as a complication of a bandage contact lens used to treat recurrent epithelial erosion. Corneal anesthesia was complete. Corneal neovascularization was evident 10 weeks later and topical bevacizumab (5 mg/ml) was introduced twice daily. Partial regression of deep stromal vessels was noticed at 3 months. Conclusion: In Meretoja’s syndrome, neurotrophic keratopathy secondary to polyneuropathy due to systemic amyloid deposits is present in the advanced stages, promotes recurrent corneal erosions. Corneal sensitivity test, AS-OCT and IVCM are crucial in the diagnosis behind any recurrent corneal erosion. The use of bandage contact lens should be avoided in Meretoja’s syndrome to prevent a possible infectious keratitis.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Contact lens induced bacterial keratitis in LCD II: Management and multimodal imaging: a case report and review of literature

Alafaleq

Knoeri

Boutboul

et al. 2020

European Journal of Ophthalmology

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“…In FIN-GAR registry patients with median age of 62.7 years the prevalence of cataract was 47% and that of glaucoma 23%. Cataract and glaucoma have been associated to AGel amyloidosis [4,6,[29][30][31][32][33][34][35], but this high prevalence in patients was new information received through this study.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, the assumption has been that renal manifestation of AGel amyloidosis are rather rare and mild in heterozygous patients [4][5][6]. However, some patients have developed even a nephrotic syndrome [26,35,41], requiring dialysis or kidney transplantation. On the other hand, homozygous patients have severe renal manifestations and they may suffer from nephrotic syndrome already in their early twenties, progressing to renal failure, dialysis treatment, and death [26,42,43].…”

Section: Discussionmentioning

confidence: 99%

Finnish gelsolin amyloidosis causes significant disease burden but does not affect survival: FIN-GAR phase II study

Schmidt

Mustonen

Kiuru-Enari

et al. 2020

Orphanet J Rare Dis

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Background: Hereditary gelsolin (AGel) amyloidosis is an autosomal dominantly inherited systemic amyloidosis that manifests with the characteristic triad of progressive ophthalmological, neurological and dermatological signs and symptoms. The National Finnish Gelsolin Amyloidosis Registry (FIN-GAR) was founded in 2013 to collect clinical data on patients with AGel amyloidosis, including altogether approximately one third of the Finnish patients. We aim to deepen knowledge on the disease burden and life span of the patients using data from the updated FIN-GAR registry. We sent an updated questionnaire concerning the symptoms and signs, symptomatic treatments and subjective perception on disease progression to 240 members of the Finnish Amyloidosis Association (SAMY). We analyzed the lifespan of 478 patients using the relative survival (RS) framework. Results: The updated FIN-GAR registry includes 261 patients. Symptoms and signs corresponding to the classical triad of ophthalmological (dry eyes in 93%; corneal lattice amyloidosis in 89%), neurological (numbness, tingling and other paresthesias in 75%; facial paresis in 67%), and dermatological (drooping eyelids in 86%; cutis laxa in 84%) manifestations were highly prevalent. Cardiac arrhythmias were reported by 15% of the patients and 5% had a cardiac pacemaker installed. Proteinuria was reported by 13% and renal failure by 5% of the patients. A total of 65% of the patients had undergone a skin or soft tissue surgery, 26% carpal tunnel surgery and 24% at least unilateral cataract surgery. As regards life span, relative survival estimates exceeded 1 for males and females until the age group of 70-74 years, for which it was 0.96. Conclusions: AGel amyloidosis causes a wide variety of ophthalmological, neurological, cutaneous, and oral symptoms that together with repeated surgeries cause a clinically significant disease burden. Severe renal and cardiac manifestations are rare as compared to other systemic amyloidoses, explaining in part the finding that AGel amyloidosis does not shorten the life span of the patients at least for the first 75 years.

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“…This form of treatment has been used in several studies following corneal graft procedures. Similarly, several authors have suggested the use of adjuvant MPG to reduce inflammation and to provide protection against further melting. Shan, Wu and Akpek describe a case of sterile corneal melt following Desçemet's stripping endo‐keratoplasty (DESK).…”

Section: Treatmentmentioning

confidence: 99%