Corneal penetration of diclofenac from a fixed combination of diclofenac-gentamicin eyedrops

Abstract

Drug levels of diclofenac in the aqueous humor well above IC-50 for cyclo-oxygenase were achieved with the regimen applied. No inhibitory effect by the gentamicin or vehicle was observed. Comparison of these data with published results of Voltaren Ophtha implies a 2-fold better penetration of diclofenac with the diclofenac-gentamicin combination.

Topical naproxen sodium for inhibition of miosis during cataract surgery. Prospective, randomized clinical trials

“…Accordingly, flurbiprofen, indomethacin and diclofenac penetrate the cornea when administered preoperatively in patients having cataract extraction, reaching concentrations in the range of 30-200 ng/ml. 14,19 Our study suggests that topical naproxen is also able to constrain aqueous PG production. In fact the naproxen concentration gained in human aqueous (approximately 370 ng/ml = 1.5 M) is able to inhibit COX activity by at least 50% in selected human and animal tissue.…”