Corneal Stromal Densitometry Evolution in a Clinical Model of Cellular Therapy for Advanced Keratoconus

Zarif, Mona El; Barrio, Jorge L. Alió del; Mingo, David; Jawad, Karim Abdul; Alió, Jorge L.

doi:10.1097/ico.0000000000003152

Cited by 8 publications

(4 citation statements)

References 39 publications

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“…In recent years, corneal densitometry has been extensively studied in keratoconus [17][18][19][20]. Corneal densitometry has been proposed as a tool for identifying keratoconus [21], and may also be useful in tracking its progression.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of brittle cornea syndrome by multimodal imaging modalities: a case report

Wang,

Zhang,

Gao

et al. 2023

BMC Ophthalmol

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Background A report of a Brittle cornea syndrome (BCS) case with bluish scleral discoloration, keratoglobus, and myopia based on multimodal imaging modalities including in vivo confocal microscopy (IVCM), high-definition optical coherence tomography (HD-OCT) and scheimpflug corneal densitometry analysis. Case presentation A 36-year-old Chinese female patient presented with significant bluish discoloration of the sclera in both eyes, extreme corneal thinning with increased corneal curvature, increased central corneal densitometry, and nystagmus. She also had scoliosis, severe osteoporosis, and thyroid disease. Conclusions Timely diagnosis, early detection, and detailed follow-up are essential for BCS. There has been no report of a BCS evaluation performed by IVCM and corneal densitometry methods thus far in the literature. Furthermore, multimodal imaging can offer a more comprehensive view of BCS and contribute to a deeper understanding of the disease. Interestingly, this is a rare case of BCS in an adult with good vision, an intact cornea, and nystagmus.

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Section: Discussionmentioning

confidence: 99%

Characteristics of brittle cornea syndrome by multimodal imaging modalities: a case report

Wang,

Zhang,

Gao

et al. 2023

BMC Ophthalmol

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“…To our current understanding, the sole published clinical data pertaining to the regeneration and therapeutic application of stem cells in the human corneal stroma originates from an earlier investigation conducted by Alio et al. 43 , 44 , 45 , 46 In their research, patients diagnosed with keratoconus were divided into three experimental groups, with individuals receiving transplantation of autologous adipose-derived adult stem cells (ADASCs), transplantation of decellularized corneal stromal lamina, and transplantation of recellularized lamina containing ADASCs, respectively. 47 Larger sample numbers and additional study are required to confirm the effectiveness of these treatments.…”

Section: Applications Of Cornea Regeneration In Ophthalmic Disease Tr...mentioning

confidence: 99%

Regenerative treatment of ophthalmic diseases with stem cells: Principles, progress, and challenges

Niu,

Ji,

Yao

et al. 2024

Advances in Ophthalmology Practice and Research

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“…The long-term observation up to 36 months did not detect changes of corneal keratometry readings and subjective refraction. However, the new ECM production did not quantitatively improve the thickness of the KC corneas, although the stromal cellularity was significantly increased within the anterior, mid, and posterior stroma [ 91 ].…”

Section: Cell-based Approach For Corneal Wound Healing and Scar Manag...mentioning

confidence: 99%

Regenerative Therapy for Corneal Scarring Disorders

Chandran,

Santra,

Rubin

et al. 2024

Biomedicines

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The cornea is a transparent and vitally multifaceted component of the eye, playing a pivotal role in vision and ocular health. It has primary refractive and protective functions. Typical corneal dysfunctions include opacities and deformities that result from injuries, infections, or other medical conditions. These can significantly impair vision. The conventional challenges in managing corneal ailments include the limited regenerative capacity (except corneal epithelium), immune response after donor tissue transplantation, a risk of long-term graft rejection, and the global shortage of transplantable donor materials. This review delves into the intricate composition of the cornea, the landscape of corneal regeneration, and the multifaceted repercussions of scar-related pathologies. It will elucidate the etiology and types of dysfunctions, assess current treatments and their limitations, and explore the potential of regenerative therapy that has emerged in both in vivo and clinical trials. This review will shed light on existing gaps in corneal disorder management and discuss the feasibility and challenges of advancing regenerative therapies for corneal stromal scarring.

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Corneal Stromal Densitometry Evolution in a Clinical Model of Cellular Therapy for Advanced Keratoconus

Abstract: Supplemental Digital Content is Available in the Text.

Cited by 8 publications

References 39 publications

Characteristics of brittle cornea syndrome by multimodal imaging modalities: a case report

Characteristics of brittle cornea syndrome by multimodal imaging modalities: a case report

Regenerative treatment of ophthalmic diseases with stem cells: Principles, progress, and challenges

Regenerative Therapy for Corneal Scarring Disorders

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