Corneal stromal regeneration—keratoconus cell therapy: a review

Shetty, Rohit; Mahendran, Krithikaa; Joshi, Parth D; Jeyabalan, Nallathambi; Jayadev, Chaitra

doi:10.1007/s00417-023-06064-7

Graefes Arch Clin Exp Ophthalmol

2023

DOI: 10.1007/s00417-023-06064-7

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Corneal stromal regeneration—keratoconus cell therapy: a review

Rohit Shetty

Krithikaa Mahendran

Parth D Joshi

et al.

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New dawn for keratoconus treatment: potential strategies for corneal stromal regeneration

Dou,

Liu,

Shi

et al. 2023

Stem Cell Res Ther

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Keratoconus is a progressive, ectatic and blinding disorder of the cornea, characterized by thinning of corneal stroma. As a highly prevalent among adolescents, keratoconus has been a leading indication for corneal transplantation worldwide. However, the severe shortage of donor corneas is a global issue, and the traditional corneal transplantation surgeries may superinduce multiple complications, necessitating efforts to develop more effective strategies for keratoconus treatment. In this review, we summarized several strategies to promote corneal stromal regeneration or improve corneal stromal thickness, including cell-based therapies, biosynthetic alternatives for inducing corneal regeneration, minimally invasive intrastromal implantation and bioengineered tissues for implantation. These strategies provided more accessible but safer alternatives from various perspectives for keratoconus treatment, paving the way for arresting the keratoconus progression in its earlier stage. For the treatments of corneal ectatic diseases beyond keratoconus, these approaches will provide important references and widen the therapy options in a donor tissue-independent manner.

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New dawn for keratoconus treatment: potential strategies for corneal stromal regeneration

Dou,

Liu,

Shi

et al. 2023

Stem Cell Res Ther

View full text Add to dashboard Cite

show abstract

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Corneal stromal regeneration—keratoconus cell therapy: a review

Cited by 1 publication

References 125 publications

New dawn for keratoconus treatment: potential strategies for corneal stromal regeneration

New dawn for keratoconus treatment: potential strategies for corneal stromal regeneration

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