Corneal thickness and curvature in normal-tension glaucoma

Morad, Yair; Sharon, Elinor; Hefetz, Limor; Nemet, Pinhas

doi:10.1016/s0002-9394(99)80086-5

Cited by 138 publications

(91 citation statements)

References 12 publications

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“…Thus, true IOP, and therefore glaucoma risk, may be underestimated in these eyes. This may explain the findings that mean CCT is thinner in patients with normal tension glaucoma compared with those having POAG, 6,7 and thicker in patients with OHT. 8,9 These findings are replicated among different racial groups.…”

Section: Introductionmentioning

confidence: 93%

The relationship between central corneal thickness and the optic disc in an elderly population: the Bridlington Eye Assessment Project

Hawker

Edmunds

Vernon

et al. 2007

Eye

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Purpose To determine population-based normative CCT data for elderly white subjects, with and without diabetes, and to explore the relationship between CCT and IOP and HRT2 measurements in such subjects with normal visual fields. Methods All eligible subjects were consecutive in a population screened for eye disease. CCT was measured by ultrasound pachymetry, and the optic disc was morphometrically defined using Heidelberg retinal tomography (HRT2). Inclusion criteria were: (1) normal visual field on suprathreshold testing and (2) corrected logMAR acuity of at least 0.3 in both eyes. Subjects with significant corneal pathology, previous corneal surgery, or known history of glaucoma or treatment for raised intraocular pressure were excluded. One eye was randomly selected from each subject for analysis. Results In all, 983 eyes of 983 subjects were included with 690 HRT images deemed acceptable for the analysis. The mean age (414 men and 569 women) was 73.3 years (minimum 65 years). Mean (SD) CCT was 544.1 (36.5) lm, with a normally distributed range of 429-633 lm. There was no significant difference in CCT between men and women (mean CCT 546.1 and 542.7 lm, respectively, P ¼ 0.15, Student's t-test), though CCT was correlated weakly and negatively with age (Pearson's r ¼ À0.063, P ¼ 0.047). Diabetic patients (n ¼ 103) had a greater mean CCT than non-diabetic patients (551.9 and 543.0 lm respectively, P ¼ 0.02). No significant correlation was found between any global optic disc parameter and CCT in the 690 eyes analysed. Conclusion Elderly white eyes with normal fields have CCTs that are normally distributed, with those from diabetic persons having greater CCTs. No clear evidence of a relationship between CCT and HRT2 optic disc parameters used in glaucoma diagnosis was found.

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Section: Introductionmentioning

confidence: 93%

The relationship between central corneal thickness and the optic disc in an elderly population: the Bridlington Eye Assessment Project

Hawker

Edmunds

Vernon

et al. 2007

Eye

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“…[4][5][6][7][8][9][10][11] Moreover, many cases of normal-tension glaucoma and ocular hypertension have been erroneously diagnosed by underestimation and overestimation of IOP by GAT in patients whose corneas are thinner or thicker than average, respectively. [12][13][14][15] Dynamic contour tonometry (DCT), a novel digital nonapplanation contact tonometer, has been proposed as an alternative method for obtaining IOP readings significantly closer to true manometric levels. 16 DCT was designed to be largely independent of structural properties of the cornea and to eliminate most of the systematic errors arising from physiological variables of the eye, which render GAT less accurate.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Goldmann applanation tonometry and dynamic contour tonometry in healthy and glaucomatous eyes

Ceruti

Morbio

Marraffa

et al. 2008

Eye

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Purpose To compare the measurements of intraocular pressure (IOP) with dynamic contour tonometry (DCT) and Goldmann applanation tonometry (GAT) in healthy and glaucomatous eyes and to evaluate the influence of corneal thickness (CCT), corneal curvature (CC), axial length (AL), and age on these tonometric alternatives. Methods Three hundred eyes of 100 healthy subjects, 100 patients with primary open angle glaucoma, and 100 patients with primary angle-closure glaucoma underwent IOP evaluation with DCT and GAT, and measurements of CCT, CC, and AL. Bland-Altman plots were used to evaluate the agreement between tonometers. Regression analysis was used to evaluate the influence of ocular structural factors on IOP measurements obtained with both tonometers. Results Bland-Altman plots indicated that the 95% limits of agreement between tonometers were À1.4 to 6.6 mmHg. DCT values measured 2.6 ± 1.9 mmHg higher than GAT readings (Po0.001). The mean IOP difference between DCT and GAT (DIOP) was higher in healthy than in glaucomatous eyes and the magnitude of difference increased with increasing CCT. A significant reduction of DIOP with an increase in both CCT (Po0.001) and IOP values (Po0.001) was found. Regression analysis showed no effect of CC, AL, and age on both DCT and GAT readings. In contrast to GAT (Po0.001), DCT measurements were not influenced by CCT (P ¼ 0.43).Conclusions IOP readings obtained by DCT were higher and less affected by CCT than those by GAT. The DIOP was higher in healthy than in glaucomatous eyes and decreased in relation to increased CCT and IOP values.

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“…Entretanto, dentre as várias fontes de erro na leitura, a espessura da córnea é um fator físico importante que influencia na rigidez corneana e, então na aferição da Po medida pelo tonômetro de aplanação (4) .…”

Section: Discussionunclassified

“…O tonômetro de aplanação de Goldmann mede a Po registrando a força necessária para achatar o ápice corneano, e baseia-se na lei de Imbert-Fick a qual defende que a superfície corneana é perfeitamente elástica e fina, não oferecendo força adicional alguma à aplanação além da pressão interna do globo ocular (4)(5)(6) . Entretanto ao usar este aparelho estamos sujeitos a alguns erros (3) .…”

Section: Resumo Introduçãounclassified

Glaucoma de pressão normal e espessura corneana central

Sakata¹,

Selonke²,

Schmitt³

et al. 2002

Arq. Bras. Oftalmol.

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Objetivo: Este estudo tem como objetivo investigar a existência de diferença da espessura corneana central (ECC) em pacientes com glaucoma de pressão normal (GPN), glaucoma crônico simples (GCS) e pacientes normais (Controle O grupo de GPN apresentou uma ECC significativamente menor quando comparado com os grupo controle (p = 0,01) e GCS (p=0,006). Entre os grupos controle e GCS não houve diferença estatística significativa (p = 0,91). Conclusão: Observou-se que numa amostra da população brasileira a ECC dos olhos com GPN é significativamente menor do que a ECC dos pacientes com GCS e do grupo controle. Normal tension glaucoma and central corneal thickness

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Corneal thickness and curvature in normal-tension glaucoma

Cited by 138 publications

References 12 publications

The relationship between central corneal thickness and the optic disc in an elderly population: the Bridlington Eye Assessment Project

The relationship between central corneal thickness and the optic disc in an elderly population: the Bridlington Eye Assessment Project

Comparison of Goldmann applanation tonometry and dynamic contour tonometry in healthy and glaucomatous eyes

Glaucoma de pressão normal e espessura corneana central

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