Corneal thickness as a risk factor for visual field loss in patients with preperimetric glaucomatous optic neuropathy

Medeiros, Felipe A.; Sample, Pamela A.; Zangwill, Linda M.; Bowd, Christopher; Aihara, Makoto; Weinreb, Robert N.

doi:10.1016/s0002-9394(03)00484-7

Cited by 232 publications

(158 citation statements)

References 34 publications

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“…Thin central corneas were shown to be a strong factor associated with progression from OH to POAG 7,16,25 or for the appearance of early defects with nonconventional perimetry in OHTs. 26,27 In summary, our data show a definite inverse relationship between the central corneal pachymetry value and the damage of the visual field.…”

Section: Discussionsupporting

confidence: 51%

Corneal thickness and visual field damage in glaucoma patients

Papadia

Sofianos

Iester

et al. 2006

Eye

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Purpose To verify whether there was a significant correlation between central corneal thickness (CCT) and visual field damage in patients with primary open angle glaucoma (POAG). Methods A total of 99 eyes with POAG were consecutively recruited. Patients were classified as glaucomatous based on visual field and optic nerve head damage. All underwent applanation tonometry, Humphrey perimetry, and measurement of CCT with ultrasonic pachymetry. Based on CCT value, the sample was split at the mode in two groups (group 1o535 mm, n ¼ 49; group 2Z535 mm, n ¼ 50

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Section: Discussionsupporting

confidence: 51%

Corneal thickness and visual field damage in glaucoma patients

Papadia

Sofianos

Iester

et al. 2006

Eye

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“…CCT is important in the management of preperimetric glaucomatous optic neuropathy, as it has been shown that patients who develop early SAP defects have thinner corneas. 37 CCT also gives an indication of the robustness of the optic nerve and is inversely associated with glaucomatous optic neuropathy, larger disc size, and a more deformable disc. 38 Corneal hysteresis has been shown to be inversely associated with visual field progression.…”

Section: Cctmentioning

confidence: 99%

A survey of investigations used for the management of glaucoma in hospital service in the United Kingdom

Gordon-Bennett

Ioannidis

Παπαγεωργίου

et al. 2008

Eye

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Aims This study surveys the current use of investigations for the management of glaucoma in hospital practice by UK ophthalmologists. Methods A total of 1007 questionnaires were posted to all active NHS consultant ophthalmologists. They were asked to indicate the type of hospital (whether university (UTH) or general (DGH) hospital), glaucoma specialist status, and availability and use of automated perimetry, disc photography, HRT, GDx, OCT, and pachymetry. Results A total of 493 completed questionnaires were received and 469 were analysed: 284 (60.6%) DGH, 185 (39.4%) UTH, 144 (30.7%) glaucoma specialists. There was good availability of automated perimetry (467, 99.6%), disc photography (420, 89.6%), pachymetry (374, 79.7%), OCT (212, 45.2%), HRT (206, 43.9%), and GDx (59, 12.6%). A total of 308 (65.7%) consultants had at least one digital imaging instrument available. The majority of consultants used SAP (347, 74.0%) and SITA-fast (282, 60.1%) for glaucoma suspects, and for monitoring glaucoma (283, 60.3% and 197, 42.0%, respectively). Some used Esterman (155, 33.0%) and Goldmann fields (90, 19.2%) in addition to SAP and SITA-fast for glaucoma suspects. Few consultants used short-wavelength automated perimetry and frequency-doubled perimetry. Of the three imaging tests, HRT was the most commonly used investigation for disc asymmetry, early glaucoma, glaucomatous progression, ocular hypertension, normal tension glaucoma, and unreliable visual fields (Po0.0001). Where pachymeters were available, 333 (89.0%) consultants and 117 (98.3%) glaucoma specialists used pachymetry in glaucoma management. Conclusions There was some variation in the use of investigations for the diagnosis and management of glaucoma, reflecting the range of techniques available. SAP, SITA-fast, and pachymetry were the most commonly utilised investigations followed by HRT. Glaucoma specialist status, type of hospital, and presence of research influenced the availability and use of all investigations, except visual fields.

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“…1,2 Patients with a CCT of p555 mm in the ocular hypertension treatment study (OHTS) had a three-fold increase in the risk of glaucoma development compared with those having CCT of X588 mm. 3 In addition, thinner CCT is associated with more severe glaucoma progression, both at first presentation to the ophthalmologist, 4 and during follow-up.…”

Section: Introductionmentioning

confidence: 99%

The relationship between central corneal thickness and the optic disc in an elderly population: the Bridlington Eye Assessment Project

Hawker

Edmunds

Vernon

et al. 2007

Eye

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Purpose To determine population-based normative CCT data for elderly white subjects, with and without diabetes, and to explore the relationship between CCT and IOP and HRT2 measurements in such subjects with normal visual fields. Methods All eligible subjects were consecutive in a population screened for eye disease. CCT was measured by ultrasound pachymetry, and the optic disc was morphometrically defined using Heidelberg retinal tomography (HRT2). Inclusion criteria were: (1) normal visual field on suprathreshold testing and (2) corrected logMAR acuity of at least 0.3 in both eyes. Subjects with significant corneal pathology, previous corneal surgery, or known history of glaucoma or treatment for raised intraocular pressure were excluded. One eye was randomly selected from each subject for analysis. Results In all, 983 eyes of 983 subjects were included with 690 HRT images deemed acceptable for the analysis. The mean age (414 men and 569 women) was 73.3 years (minimum 65 years). Mean (SD) CCT was 544.1 (36.5) lm, with a normally distributed range of 429-633 lm. There was no significant difference in CCT between men and women (mean CCT 546.1 and 542.7 lm, respectively, P ¼ 0.15, Student's t-test), though CCT was correlated weakly and negatively with age (Pearson's r ¼ À0.063, P ¼ 0.047). Diabetic patients (n ¼ 103) had a greater mean CCT than non-diabetic patients (551.9 and 543.0 lm respectively, P ¼ 0.02). No significant correlation was found between any global optic disc parameter and CCT in the 690 eyes analysed. Conclusion Elderly white eyes with normal fields have CCTs that are normally distributed, with those from diabetic persons having greater CCTs. No clear evidence of a relationship between CCT and HRT2 optic disc parameters used in glaucoma diagnosis was found.

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Corneal thickness as a risk factor for visual field loss in patients with preperimetric glaucomatous optic neuropathy

Cited by 232 publications

References 34 publications

Corneal thickness and visual field damage in glaucoma patients

Corneal thickness and visual field damage in glaucoma patients

A survey of investigations used for the management of glaucoma in hospital service in the United Kingdom

The relationship between central corneal thickness and the optic disc in an elderly population: the Bridlington Eye Assessment Project

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