Corneal Tomographic Analysis Among Patients With Thyroid Gland Dysfunction

Bassiouny, Rania M.; Awad, Eman; Gaafar, Walid; Kyrillos, Fady; Samra, Waleed Abou; Abdelhameed, Ameera G

doi:10.3928/1081597x-20210105-03

Cited by 9 publications

(11 citation statements)

References 31 publications

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“…This agreed with Carreira et al, who assessed the tear film stability and corneal epithelial thickness in patients with GD with and without Graves orbitopathy and showed that the level of eye dryness and corneal thinning were higher in GD regardless of GO status [25]. A study by Bassioujny et al, who used the Pentacam (Oculus Optikgeräte GmbH) to evaluate the cornea of patients with thyroid gland dysfunction and controls and revealed that patients with hyperthyroidism tend to have thinner corneas and more abnormal tomographic parameters correlating with keratoconus [26]. Alternative research on tear film evaluation used other methods in TED, such as Alanazi et al, who employed the phenol red thread test followed by the TBUT test with a 10-min break between the tests.…”

Section: Discussionmentioning

confidence: 99%

Anterior Segment Optical Coherence Tomography Study of the Anterior Ocular Surface in Thyroid Eye Diseases

Anwar

Mahmoud²,

Hassan³

et al. 2022

Egyptian Journal of Clinical Ophthalmology

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Purpose: Use the anterior segment optical coherence tomography (AS-OCT) to evaluate the tear meniscus parameters, total corneal thickness (CT), and epithelial thickness in active and inactive thyroid eye disease (TED) patients and compare them with age-matched controls. Patients and methods: This is a prospective case-control clinical study in which the subjects were divided into three groups, group I of inactive thyroid patients, group II of active thyroid patients, and group III of healthy controls. The AS-OCT was used to measure lower tear meniscus parameters (tear meniscus height (TMH), tear meniscus depth (TMD), and tear meniscus area (TMA)), total CT, and epithelial thickness. Results: All tear meniscus parameters (TMH, TMD, and TMA) were reduced in groups I and II with more reduction in group II with no significant difference between them with a significant difference when comparing groups I and II with group III. The mean total CT was 496.7±19.9 in group I, 497.8±20.6 in group II, and 520.3±23.9 in group III with no significant difference (p-value = 0.757) between groups I and II while there was a significant difference when compared with healthy controls. The mean epithelial thickness was 46.5±2.6 in group I, 47.3±2.7 in group II, and 53.2±4.5 in group III with no significant difference between groups I and II while there was a significant difference when compared with healthy control. Conclusion: TED patients had reduced tear film parameters regardless of the thyroid activity, also the total CT and epithelial thickness was thinner in comparison with healthy controls.

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Section: Discussionmentioning

confidence: 99%

Anterior Segment Optical Coherence Tomography Study of the Anterior Ocular Surface in Thyroid Eye Diseases

Anwar

Mahmoud²,

Hassan³

et al. 2022

Egyptian Journal of Clinical Ophthalmology

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“…Previous studies mostly analysed corneal thickness in patients with TED [ 15 , 16 ] and hypothyroidism [ 7 , 17 , 18 , 19 , 20 , 21 ]. In a study that included 27 individuals with TED and 30 healthy individuals, Karabulut et al did not observe a significant difference in central corneal thickness between patients with TED and healthy individuals (with Goldmann-correlated intraocular pressure (IOPg) and corneal-compensated IOP (IOPcc) being significantly increased and corneal hysteresis (CH) being significantly decreased in patients with TED) [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, a study that included 48 patients with HT and 49 healthy controls did not observe a significant difference in central corneal thickness between these two groups, while IOPcc was significantly higher in the HT group [ 17 ]. However, Bassiouny et al concluded that thyroid gland dysfunction contributes to the development of corneal tomographic changes [ 21 ]. In a study that included 50 patients with thyroid gland dysfunction and 50 healthy individuals, the authors observed a significant increase in central corneal thickness levels in patients with hypothyroidism in comparison to both healthy individuals and patients with hyperthyroidism [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, Bassiouny et al concluded that thyroid gland dysfunction contributes to the development of corneal tomographic changes [ 21 ]. In a study that included 50 patients with thyroid gland dysfunction and 50 healthy individuals, the authors observed a significant increase in central corneal thickness levels in patients with hypothyroidism in comparison to both healthy individuals and patients with hyperthyroidism [ 21 ]. Additionally, central corneal thickness levels positively correlated with TSH levels and negatively correlated with T4 levels [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

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Association between Thyroid Function and Ocular Parameters

Leko

Pleić

Lešin

et al. 2022

Biology

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During development, thyroid hormones play an important role in eye development, while in adults, some pathological thyroid conditions can affect the normal functioning of the eyes. Thyroid eye disease is the most well-known eye pathology caused by a pathological thyroid condition. Few studies have investigated the association between ocular parameters and thyroid function. Thus, in this study, we aimed to examine whether thyroid activity affects ocular parameters. This cross-sectional study included 4633 healthy adults recruited within the 10,001 Dalmatians project of the Croatian Biobank. The plasma levels of thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), thyroglobulin (Tg), thyroglobulin antibodies (TgAb), and thyroid peroxidase antibodies (TPOAb) were measured by an immunoassay. We determined 20 ocular parameters for each participant (10 for each eye, including corneal radius, corneal thickness, anterior chamber depth, anterior chamber angle, lens thickness, posterior chamber length, axial length, intraocular lens power (IOL), spherical power, and cylinder power). Patients with hyperthyroidism had thicker corneas compared to euthyroid individuals. Corneal thickness was also negatively associated with plasma TSH levels. Intra-ocular lens power was higher in patients with clinical hypothyroidism, while spherical power was higher in euthyroid individuals with positive antibodies compared to euthyroid individuals. Intra-ocular lens power negatively correlated with fT4 levels, while spherical power positively correlated with TgAb, TPOAb, and Tg levels and negatively correlated with TSH levels. The anterior chamber angle was positively associated with plasma TSH levels and TPOAb levels and negatively associated with plasma fT4 levels. These findings suggest an interesting interplay between ophthalmic measures and thyroid status, detectable even in the general adult population.

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“…The prevalence of thyroid gland dysfunction was reported in KC patients. Thyroxin was found to cause biochemical changes in the corneal stroma as a result of thyroxin-receptor interaction [8][9][10][11]. Vitamin D receptors (VDR) are found in the cornea, lens, and retinal pigment epithelium [12,13].…”

Section: Introductionmentioning

confidence: 99%

Thyroid gland dysfunction and vitamin D receptor gene polymorphism in keratoconus

Awad

Torky

Bassiouny

et al. 2022

Eye

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Objectives To detect the serum level of thyroid hormones, vitamin D and vitamin D receptors (VDR) polymorphism in keratoconus (KC) patients and to identify the association between vitamin D deficiency and thyroid dysfunction in KC. Methods This cross sectional study included 177 KC patients with no thyroid disorders compared to 85 healthy controls with normal corneal tomography. Measurements of thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free tetraiodothyronine (FT4) and serum 25-OH vitamin D were done using Enzyme linked immusoassay (ELISA test). VDR polymorphisms were tested including [Taq I (rs731236), Apa I (rs7975232) and Bsm I (rs1544410)] using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results An increase in frequency of thyroid disorders (P = 0.04), decrease in serum 25(OH) vitamin D level (P < 0.001), Taq 1 and tt genotype (P < 0.001) were significantly distributed in KC patients. A significantly higher serum 25(OH) vitamin D level was reported in TT genotype, while insufficient level was more common in Tt genotype (P < 0.001). A deficient serum 25(OH) vitamin D level was predominant in tt genotype (P < 0.001). A 95% confidence interval was in TSH (1.603, 2.946), FT4 (24.145, 77.06), hypothyroidism (1.062, 67.63), insufficient (2.936, 11.643) and deficient vitamin D (5.283, 28.704) and all were significant risk factors for KC with (P < 0.05). Conclusions Both thyroid disorders and low vitamin D are potential factors for KC development. Studying VDR at the molecular level provides interesting avenues for future research toward the identification of new KC cases.

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Corneal Tomographic Analysis Among Patients With Thyroid Gland Dysfunction

Cited by 9 publications

References 31 publications

Anterior Segment Optical Coherence Tomography Study of the Anterior Ocular Surface in Thyroid Eye Diseases

Anterior Segment Optical Coherence Tomography Study of the Anterior Ocular Surface in Thyroid Eye Diseases

Association between Thyroid Function and Ocular Parameters

Thyroid gland dysfunction and vitamin D receptor gene polymorphism in keratoconus

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