Corneal topography in keratoconus evaluated more than 30 years after penetrating keratoplasty: a Fourier harmonic analysis

Abstract

The aim of this observational study was to examine the characteristics of anterior and posterior corneal topography in keratoconic eyes more than 30 years after penetrating keratoplasty (PK). Patients who maintained clear grafts for more than 30 years after PK were included and divided into the keratoconus (KC) group or other diseases (Others) group, based on the primary indication. Twenty-six eyes of 26 patients were included. The KC group and the Others group included 14 eyes and 12 eyes, respectively. The KC group participants were younger at the time of surgery (P = 0.03). No differences were found in best-spectacle-corrected visual acuity, keratometric power, and central-corneal-thickness. Based on corneal topography using Fourier harmonic analyses, regular astigmatism in the anterior cornea was significantly larger (P = 0.047) and the spherical component in the posterior cornea was significantly lower (P = 0.01) in the KC group. The area under the receiver operating characteristic curve of the spherical component, regular astigmatism, asymmetry component, and higher-order irregularity were 66.07%, 63.10%, 57.14%, and 59.23%, respectively, in the anterior cornea and 80.65%, 52.98%, 63.10%, and 63.99%, respectively, in the posterior cornea. Our results suggested that Fourier harmonic analysis of corneal topography could be useful for patients with KC long after PK.

Regular and irregular astigmatism of bullous keratopathy using Fourier harmonic analysis with anterior segment optical coherence tomography

“…However, advancements in OCT technology later made it possible to use anterior segment optical coherence tomography (AS-OCT) to obtain topographic data for both the anterior surface and the posterior surface of the cornea. Fourier harmonic analysis with AS-OCT has been used in recent years to evaluate the topographic changes associated with primary and recurrent pterygium 39 , ptosis surgery 40 , penetrating keratoplasty for keratoconus 41 , rigid gas permeable contact lens use for keratoconus 42 , and Fuchs endothelial corneal dystrophy (FECD) 43 . A study also analyzed the relationship between regular astigmatism pattern and irregular astigmatism in normal subjects 44 .…”