Corneal Toxicity From Topical Ocular and Systemic Medications

Fraunfelder, Frederick W.

doi:10.1097/01.ico.0000240084.27663.fd

Cited by 84 publications

(39 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several adverse ocular reactions, mainly involving long-term abuse, have been reported. [23][24][25][26] A direct toxic effect on epithelial cells and stromal keratocytes has been shown. 27,28 We cannot exclude the possibility that the use of topical anesthetic eyedrops may have had an adjunctive deleterious effect in promoting stromal tissue melting.…”

Section: Discussionmentioning

confidence: 99%

Acanthamoeba keratitis with perforation after corneal crosslinking and bandage contact lens use

Rama¹,

Matteo²,

Matuška³

et al. 2009

Journal of Cataract and Refractive Surgery

142

View full text Add to dashboard Cite

A 32-year-old man with keratoconus developed corneal melting 5 days after riboflavin/ultraviolet-A corneal collagen crosslinking (CXL). Corneal scraping was positive for Acanthamoeba. The patient was unaware that he was wearing a bandage contact lens and repeatedly rinsed his face and eyelids with tap water. Because of corneal perforation, a large therapeutic keratoplasty à chaud was performed. Although CXL is considered a safe procedure, this case emphasizes the potential risks. We discuss the potential effects of deepithelialization, contact lens placement, instillation of topical nonsteroidal antiinflammatory drugs and anesthetic agents, and the possible role of apoptosis when performing CXL treatment for keratoconus.

show abstract

Section: Discussionmentioning

confidence: 99%

Acanthamoeba keratitis with perforation after corneal crosslinking and bandage contact lens use

Rama¹,

Matteo²,

Matuška³

et al. 2009

Journal of Cataract and Refractive Surgery

142

View full text Add to dashboard Cite

show abstract

“…The remarkable recovery with steroids tempts the caretaker to overuse these drugs, and the chronicity of this disease demands strict surveillance against steroid abuse, which inevitably leads to side effects, such as cataracts and glaucoma. [1][2][3][4] The physician's primary objective with the patient with VKC is to prevent and minimize acute flare ups, as well as to treat them when they do occur with the safest therapy available. A major risk factor for a worse visual outcome is a higher number and severity of recurrences, as well as longer disease duration.…”

Section: Topicalmentioning

confidence: 99%

Topical cyclosporine prevents seasonal recurrences of vernal keratoconjunctivitis in a randomized, double-masked, controlled 2-year study

Lambìase

Leonardi

Deligianni

et al. 2011

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

“…2 Currently used steroidal and nonsteroidal drugs are not ideal and have many adverse effects on the cornea. 3 In the present study, we tested the anti-inflammatory effects of ethyl pyruvate (EP) in a mouse model of lipopolysaccharide-induced inflammation.…”

mentioning

confidence: 99%

Ethyl Pyruvate Ameliorates Endotoxin-Induced Corneal Inflammation

Gupta¹,

Du²,

Piluek³

et al. 2012

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

PURPOSE. The purpose of this study was to evaluate the antiinflammatory effect of ethyl pyruvate (EP) in a mouse model of lipopolysaccharide (LPS)-induced corneal inflammation.METHODS. LPS was injected intrastromally into the corneas of C57BL/6 mice followed by treatment with a solution of 2.5% EP in 0.2% hydroxypropyl methylcellulose (HPMC) every 90 minutes during the course of 12 hours. Prednisolone acetate 1% solution (PRED FORTE) was used as a positive control. Mice were sacrificed after 3 days, and corneas were examined by in vivo confocal microscopy and analyzed for infiltrated cells by flow cytometry. Gr-1, TNF-a, and pNF-jB-p65 were detected immunohistochemically, and TNF-a, IL-6, and IL-1b levels were quantified by ELISA.RESULTS. LPS-induced haze in mice corneas was decreased by 2-fold upon EP treatment; however, it was not changed upon PRED FORTE treatment. Flow cytometry and immunohistochemistry showed infiltration of leukocytes in the LPS-treated corneas; among the infiltrated cells, neutrophils (Gr-1þ and CD11bþ) and macrophages (F4/80þ and CD11bþ) were 3403.4-and 4.5-fold higher in number, respectively, than in vehicle-treated control corneas. EP or PRED FORTE treatment of LPS-injected corneas decreased the number of neutrophils 7.5-and 7.2-fold and macrophages by 5.6-and 3.5-fold, respectively. Both EP and PRED FORTE decreased TNF-a and IL-6 expression considerably, and to a lesser extent IL-1b expression, in the LPS-treated corneas.CONCLUSIONS. The present study demonstrated that EP reduces LPS-induced inflammation in the cornea and thus may have a potential therapeutic application in the inhibition of corneal inflammation. (Invest Ophthalmol Vis Sci. 2012;53:6589-6599)

show abstract

Corneal Toxicity From Topical Ocular and Systemic Medications

Abstract: Ophthalmologists need to be aware of potential corneal toxicities that can arise from commonly prescribed medications.

Cited by 84 publications

References 65 publications

Acanthamoeba keratitis with perforation after corneal crosslinking and bandage contact lens use

Acanthamoeba keratitis with perforation after corneal crosslinking and bandage contact lens use

Topical cyclosporine prevents seasonal recurrences of vernal keratoconjunctivitis in a randomized, double-masked, controlled 2-year study

Ethyl Pyruvate Ameliorates Endotoxin-Induced Corneal Inflammation

Contact Info

Product

Resources

About